2018
Inhibition of phosphodiesterase 2 reverses gp91phox oxidase-mediated depression- and anxiety-like behavior
Huang X, Xiaokaiti Y, Yang J, Pan J, Li Z, Luria V, Li Y, Song G, Zhu X, Zhang H, O'Donnell J, Xu Y. Inhibition of phosphodiesterase 2 reverses gp91phox oxidase-mediated depression- and anxiety-like behavior. Neuropharmacology 2018, 143: 176-185. PMID: 30268520, DOI: 10.1016/j.neuropharm.2018.09.039.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntioxidantsAnxiety DisordersCell LineCorticosteroneCyclic Nucleotide Phosphodiesterases, Type 2Depressive DisorderDose-Response Relationship, DrugHippocampusImidazolesMaleMice, Inbred ICRNADPH Oxidase 2NADPH OxidasesNeuronsOxidative StressPhosphodiesterase InhibitorsPsychotropic DrugsReactive Oxygen SpeciesTriazinesConceptsAnxiolytic-like effectsBAY 60Oxidative stressNADPH oxidase inhibitor apocyninPDE2 inhibitor Bay 60Prevalence of depressionOxidase inhibitor apocyninPhosphodiesterase 2Stress-related depressionAnxiety-like behaviorSource of ROSBDNF levelsNeuroprotective mechanismsStressed miceInhibitor apocyninCAMP/cGMPNADPH subunitsBehavioral abnormalitiesGp91phox expressionAntioxidant strategiesPDE2 inhibitionAntioxidant defenseDepressionGp91phoxVivo tests
2010
APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex
Shimomura Y, Agalliu D, Vonica A, Luria V, Wajid M, Baumer A, Belli S, Petukhova L, Schinzel A, Brivanlou A, Barres B, Christiano A. APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex. Nature 2010, 464: 1043-1047. PMID: 20393562, PMCID: PMC3046868, DOI: 10.1038/nature08875.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBeta CateninCell DifferentiationCell LineCell ProliferationChick EmbryoChromosome MappingChromosomes, Human, Pair 18Genes, DominantGenes, ReporterHairHair FollicleHumansHypotrichosisIntracellular Signaling Peptides and ProteinsMembrane GlycoproteinsMembrane ProteinsMiceMutant ProteinsNeuronsPoint MutationScalpSignal TransductionSkinSpinal CordStem CellsWnt ProteinsXenopus laevisXenopus ProteinsConceptsHereditary hypotrichosis simplexSignal transduction pathwaysHypotrichosis simplexMesenchymal cell compartmentGenetic linkage analysisNovel Wnt inhibitorsMembrane-bound glycoproteinTransduction pathwaysHuman hair folliclesLinkage analysisAPCDD1Functional studiesHair folliclesWnt inhibitorsCell compartmentDowny hairsGenesImportant componentThick hairPathwayHairGlycoproteinCompartmentsDegenerative processFamily