2010
APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex
Shimomura Y, Agalliu D, Vonica A, Luria V, Wajid M, Baumer A, Belli S, Petukhova L, Schinzel A, Brivanlou A, Barres B, Christiano A. APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplex. Nature 2010, 464: 1043-1047. PMID: 20393562, PMCID: PMC3046868, DOI: 10.1038/nature08875.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBeta CateninCell DifferentiationCell LineCell ProliferationChick EmbryoChromosome MappingChromosomes, Human, Pair 18Genes, DominantGenes, ReporterHairHair FollicleHumansHypotrichosisIntracellular Signaling Peptides and ProteinsMembrane GlycoproteinsMembrane ProteinsMiceMutant ProteinsNeuronsPoint MutationScalpSignal TransductionSkinSpinal CordStem CellsWnt ProteinsXenopus laevisXenopus ProteinsConceptsHereditary hypotrichosis simplexSignal transduction pathwaysHypotrichosis simplexMesenchymal cell compartmentGenetic linkage analysisNovel Wnt inhibitorsMembrane-bound glycoproteinTransduction pathwaysHuman hair folliclesLinkage analysisAPCDD1Functional studiesHair folliclesWnt inhibitorsCell compartmentDowny hairsGenesImportant componentThick hairPathwayHairGlycoproteinCompartmentsDegenerative processFamily
2007
Lateral motor column axons execute a ternary trajectory choice between limb and body tissues
Luria V, Laufer E. Lateral motor column axons execute a ternary trajectory choice between limb and body tissues. Neural Development 2007, 2: 13. PMID: 17605791, PMCID: PMC1949814, DOI: 10.1186/1749-8104-2-13.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAxonsBody PatterningBone Morphogenetic Protein Receptors, Type ICell DifferentiationEphrinsExtremitiesGene Expression Regulation, DevelopmentalGrowth ConesHomeodomain ProteinsKruppel-Like Transcription FactorsLIM-Homeodomain ProteinsMesodermMiceMice, KnockoutMotor NeuronsMuscle, SkeletalNeuronal PlasticityPromyelocytic Leukemia Zinc Finger ProteinReceptors, Eph FamilySpinal CordTranscription FactorsConceptsLateral motor columnLMC axonsHindlimb levelsSpinal cord lateral motor columnMotor columnAxons of neuronsIntermediate choice pointsVentral flankBody tissuesMotor nervesLMC neuronsAxonal trajectoriesLimb trajectoriesAxonsTopographic map formationTarget tissuesLimbTissueTranscription factor codeVentral limbNeuronsMap formationMesenchymeInnervationNerve