TBIO-26. NON-CANONICAL OPEN READING FRAMES ENCODE FUNCTIONAL PROTEINS ESSENTIAL FOR CANCER CELL SURVIVAL
Prensner J, Enache O, Luria V, Krug K, Clauser K, Dempster J, Karger A, Wang L, Stumbraite K, Wang V, Botta G, Lyons N, Goodale A, Kalani Z, Fritchman B, Brown A, Alan D, Green T, Yang X, Jaffe J, Roth J, Piccioni F, Kirschner M, Ji Z, Root D, Golub T. TBIO-26. NON-CANONICAL OPEN READING FRAMES ENCODE FUNCTIONAL PROTEINS ESSENTIAL FOR CANCER CELL SURVIVAL. Neuro-Oncology 2020, 22: iii471-iii471. PMCID: PMC7715501, DOI: 10.1093/neuonc/noaa222.849.Peer-Reviewed Original ResearchOpen reading frameNon-canonical open reading framesProtein translationReading frameMultiple cancer typesPutative non-coding RNAProtein-coding genesSingle-cell RNA sequencingNon-canonical proteinsFunctional genomic screensCancer-implicated genesCancer cell linesCell-autonomous mannerNon-coding RNANon-coding RNAsGene expression changesPotential cancer therapeutic targetCell linesHEK293T cellsCancer cell survivalCancer therapeutic targetNon-gonadal tissuesCell cycle arrestRibosome profilingCancer cell types