Sub-Acute Treatment of Curcumin Derivative J147 Ameliorates Depression-Like Behavior Through 5-HT1A-Mediated cAMP Signaling
Li J, Chen L, Li G, Chen X, Hu S, Zheng L, Luria V, Lv J, Sun Y, Xu Y, Yu Y. Sub-Acute Treatment of Curcumin Derivative J147 Ameliorates Depression-Like Behavior Through 5-HT1A-Mediated cAMP Signaling. Frontiers In Neuroscience 2020, 14: 701. PMID: 32733195, PMCID: PMC7360862, DOI: 10.3389/fnins.2020.00701.Peer-Reviewed Original ResearchAntidepressant-like effectsDepression-like behaviorSub-acute treatmentMajor depressive disorderAcute treatmentNAD-299Rapid antidepressant-like effectsNeurotrophic factor levelsTail suspension testHippocampus of miceMale ICR miceSevere mental disordersMouse cortical tissueDose-dependent mannerRadioligand binding assaysMechanism of actionBDNF expressionImmobility timeICR miceNAS-181Depressive disorderReceptor subtypesTreatment periodSuspension testMental disorderstrans-Resveratrol ameliorates anxiety-like behaviors and neuropathic pain in mouse model of post-traumatic stress disorder
Yuan Y, Zhen L, Li Z, Xu W, Leng H, Xu W, Zheng V, Luria V, Pan J, Tao Y, Zhang H, Cao S, Xu Y. trans-Resveratrol ameliorates anxiety-like behaviors and neuropathic pain in mouse model of post-traumatic stress disorder. Journal Of Psychopharmacology 2020, 34: 726-736. PMID: 32308103, DOI: 10.1177/0269881120914221.Peer-Reviewed Original ResearchConceptsBrain-derived neurotrophic factor (BDNF) expressionPhosphorylated cAMP response elementAnxiety-like behaviorNeurotrophic factor expressionNeuropathic painCAMP response elementBrain-derived neurotrophic factor levelsGlucocorticoid receptorFactor expressionProlonged stressStress-induced anxiety-like behaviorStress disorderCold allodynia testsNeurotrophic factor levelsAdrenal axis functionPain-related regionsLocomotor activity testSerum corticosterone levelsMarble burying testNumber of marblesProtein kinase APost-traumatic stress disorderEnzyme-linked immunosorbentClassical animal modelsResponse element