2020
Sub-Acute Treatment of Curcumin Derivative J147 Ameliorates Depression-Like Behavior Through 5-HT1A-Mediated cAMP Signaling
Li J, Chen L, Li G, Chen X, Hu S, Zheng L, Luria V, Lv J, Sun Y, Xu Y, Yu Y. Sub-Acute Treatment of Curcumin Derivative J147 Ameliorates Depression-Like Behavior Through 5-HT1A-Mediated cAMP Signaling. Frontiers In Neuroscience 2020, 14: 701. PMID: 32733195, PMCID: PMC7360862, DOI: 10.3389/fnins.2020.00701.Peer-Reviewed Original ResearchAntidepressant-like effectsDepression-like behaviorSub-acute treatmentMajor depressive disorderAcute treatmentNAD-299Rapid antidepressant-like effectsNeurotrophic factor levelsTail suspension testHippocampus of miceMale ICR miceSevere mental disordersMouse cortical tissueDose-dependent mannerRadioligand binding assaysMechanism of actionBDNF expressionImmobility timeICR miceNAS-181Depressive disorderReceptor subtypesTreatment periodSuspension testMental disorders
2018
EphB2 Deficiency Induces Depression-Like Behaviors and Memory Impairment: Involvement of NMDA 2B Receptor Dependent Signaling
Zhen L, Shao T, Luria V, Li G, Li Z, Xu Y, Zhao X. EphB2 Deficiency Induces Depression-Like Behaviors and Memory Impairment: Involvement of NMDA 2B Receptor Dependent Signaling. Frontiers In Pharmacology 2018, 9: 862. PMID: 30131699, PMCID: PMC6090375, DOI: 10.3389/fphar.2018.00862.Peer-Reviewed Original ResearchDepression-like behaviorMemory impairmentN-methyl-D-aspartate receptorsReceptor tyrosine kinase EphB2Adult hippocampal neurogenesisNMDA receptor subtypesWild-type littermatesMorris water mazeReceptor-dependent signalingImportant candidate targetEphB2 functionHippocampal neurogenesisNeurotrophic factorKO miceReceptor subtypesNeurogenic nicheExcitatory neuronsTail suspensionBehavioral alterationsBehavioral abnormalitiesCognitive disordersWater mazeNeuropsychiatric disordersCognitive deficitsProgenitor neurons