2018
Trajectories of changes in glucose tolerance in a multiethnic cohort of obese youths: an observational prospective analysis
Galderisi A, Giannini C, Weiss R, Kim G, Shabanova V, Santoro N, Pierpont B, Savoye M, Caprio S. Trajectories of changes in glucose tolerance in a multiethnic cohort of obese youths: an observational prospective analysis. The Lancet Child & Adolescent Health 2018, 2: 726-735. PMID: 30236381, PMCID: PMC6190831, DOI: 10.1016/s2352-4642(18)30235-9.Peer-Reviewed Original ResearchConceptsImpaired glucose toleranceNormal glucose toleranceOral disposition indexPersistent impaired glucose toleranceGlucose toleranceDisposition indexMultiethnic cohortObese adolescentsInsulin secretionObese youthBaseline normal glucose toleranceOral glucose tolerance testHigh-risk ethnic groupsStudy periodObservational prospective analysisPediatric obesity clinicAmerican Diabetes AssociationGlucose tolerance testAmerican Heart AssociationType 2 diabetesBody insulin sensitivityEthnic originΒ-cell responseΒ-cell functionBlack ethnic origin
2010
Ethnic differences in lipoprotein subclasses in obese adolescents: importance of liver and intraabdominal fat accretion
D'Adamo E, Northrup V, Weiss R, Santoro N, Pierpont B, Savoye M, O'Malley G, Caprio S. Ethnic differences in lipoprotein subclasses in obese adolescents: importance of liver and intraabdominal fat accretion. American Journal Of Clinical Nutrition 2010, 92: 500-508. PMID: 20573788, PMCID: PMC2921534, DOI: 10.3945/ajcn.2010.29270.Peer-Reviewed Original ResearchConceptsHepatic fat fractionObese adolescentsLarge HDLEthnic differencesFat accretionCardiometabolic risk factorsDeleterious metabolic effectsNormal glucose toleranceLipoprotein particle numberVisceral fat depositionLiver fat contentLarge VLDL particlesLarge HDL particlesImportance of liverMagnetic resonance imagingAfrican AmericansSuccessive tertilesMultivariate adjustmentGlucose toleranceLiver fatLower triglyceridesLipoprotein concentrationsRisk factorsLipoprotein subclassesMetabolic effectsHigh normal fasting glucose level in obese youth: a marker for insulin resistance and beta cell dysregulation
O’Malley G, Santoro N, Northrup V, D’Adamo E, Shaw M, Eldrich S, Caprio S. High normal fasting glucose level in obese youth: a marker for insulin resistance and beta cell dysregulation. Diabetologia 2010, 53: 1199-1209. PMID: 20204321, DOI: 10.1007/s00125-010-1693-0.Peer-Reviewed Original ResearchConceptsBeta-cell functionPlasma glucosePlasma glucose levelsInsulin sensitivityObese youthGlucose levelsType 2 diabetes mellitusConclusions/interpretationThese dataAdverse cardiovascular profileAims/hypothesisAImpaired glucose toleranceCell functionBMI z-scoreCross-sectional analysisAUC 2Standard OGTTCardiovascular profileDiabetes mellitusGlucose toleranceH glucoseInsulin resistanceRisk factorsInterpretationThese dataCardiovascular diseaseCell dysregulation