2020
A Low ω-6 to ω-3 PUFA Ratio (n–6:n–3 PUFA) Diet to Treat Fatty Liver Disease in Obese Youth
Van Name MA, Savoye M, Chick JM, Galuppo BT, Feldstein AE, Pierpont B, Johnson C, Shabanova V, Ekong U, Valentino PL, Kim G, Caprio S, Santoro N. A Low ω-6 to ω-3 PUFA Ratio (n–6:n–3 PUFA) Diet to Treat Fatty Liver Disease in Obese Youth. Journal Of Nutrition 2020, 150: 2314-2321. PMID: 32652034, PMCID: PMC7467848, DOI: 10.1093/jn/nxaa183.Peer-Reviewed Original ResearchConceptsFatty liver diseasePNPLA3 rs738409 genotypeLiver diseaseAlanine aminotransferaseRs738409 genotypeInsulin sensitivityObese youthNonalcoholic fatty liver diseaseGenotype groupsWhole-body insulin sensitivityBody insulin sensitivityLinoleic acid metabolitesHepatic fat fractionMann-Whitney U testDiet imbalanceNormocaloric dietPrimary outcomeLDL cholesterolDietary interventionFatty liverUnblinded studyObese adolescentsPUFA dietMetabolic parametersStable weight
2018
Trajectories of changes in glucose tolerance in a multiethnic cohort of obese youths: an observational prospective analysis
Galderisi A, Giannini C, Weiss R, Kim G, Shabanova V, Santoro N, Pierpont B, Savoye M, Caprio S. Trajectories of changes in glucose tolerance in a multiethnic cohort of obese youths: an observational prospective analysis. The Lancet Child & Adolescent Health 2018, 2: 726-735. PMID: 30236381, PMCID: PMC6190831, DOI: 10.1016/s2352-4642(18)30235-9.Peer-Reviewed Original ResearchConceptsImpaired glucose toleranceNormal glucose toleranceOral disposition indexPersistent impaired glucose toleranceGlucose toleranceDisposition indexMultiethnic cohortObese adolescentsInsulin secretionObese youthBaseline normal glucose toleranceOral glucose tolerance testHigh-risk ethnic groupsStudy periodObservational prospective analysisPediatric obesity clinicAmerican Diabetes AssociationGlucose tolerance testAmerican Heart AssociationType 2 diabetesBody insulin sensitivityEthnic originΒ-cell responseΒ-cell functionBlack ethnic origin