2017
Gender difference in kidney electrolyte transport. I. Role of AT1a receptor in thiazide-sensitive Na+-Cl− cotransporter activity and expression in male and female mice
Li J, Hatano R, Xu S, Wan L, Yang L, Weinstein AM, Palmer L, Wang T. Gender difference in kidney electrolyte transport. I. Role of AT1a receptor in thiazide-sensitive Na+-Cl− cotransporter activity and expression in male and female mice. American Journal Of Physiology. Renal Physiology 2017, 313: f505-f513. PMID: 28566500, PMCID: PMC5582908, DOI: 10.1152/ajprenal.00087.2017.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin IIAnimalsDiuresisFemaleHydrochlorothiazideKidneyMaleMice, KnockoutNatriuresisPhenotypeProtein Serine-Threonine KinasesReceptor, Angiotensin, Type 1Receptors, DrugSex CharacteristicsSodium Chloride SymportersSodium-Hydrogen Exchanger 3Sodium-Hydrogen ExchangersSolute Carrier Family 12, Member 3ConceptsUrine volumeKO miceCotransporter activityRenal clearance experimentsReceptor knockout miceGlomerular filtration rateBolus intravenous injectionDelivery of NaClNCC protein expressionGender differencesFiltration rateFemale miceAT1A receptorClearance experimentsKO animalsIntravenous injectionNCC expressionDistal nephronFractional NaKnockout miceMale KOProximal tubulesHCTZMiceNHE3 expression
2012
Regulation of glomerulotubular balance. II. Impact of angiotensin II on flow-dependent transport
Du Z, Wan L, Yan Q, Weinbaum S, Weinstein A, Wang T. Regulation of glomerulotubular balance. II. Impact of angiotensin II on flow-dependent transport. American Journal Of Physiology. Renal Physiology 2012, 303: f1507-f1516. PMID: 22952281, PMCID: PMC3532483, DOI: 10.1152/ajprenal.00277.2012.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin IIAngiotensin II Type 1 Receptor BlockersAnimalsBicarbonatesBiological TransportEnzyme InhibitorsFemaleHemostasisIn Vitro TechniquesKidney GlomerulusKidney TubulesLosartanMacrolidesMiceMice, KnockoutModels, AnimalProton-Translocating ATPasesReceptor, Angiotensin, Type 1SodiumSodium-Hydrogen Exchanger 3Sodium-Hydrogen ExchangersConceptsNa(+)-H(+) exchanger 3Mouse tubulesImpact of angiotensin IIH-ATPaseMicroperfused in vitroAT(2) receptorsAT(1A) receptorFlow-mediated changesH-ATPase activityParacellular Cl(-Receptor availabilityAngiotensin IIAT(1ARegulate Na(+Increased Na(+Local angiotensinBasolateral transportJ(HCO3Mouse kidneyNet fluidInhibitor bafilomycinProtein levelsMiceReceptorsTubules
2003
Role of PKC and calcium in modulation of effects of angiotensin II on sodium transport in proximal tubule
Du Z, Ferguson W, Wang T. Role of PKC and calcium in modulation of effects of angiotensin II on sodium transport in proximal tubule. American Journal Of Physiology. Renal Physiology 2003, 284: f688-f692. PMID: 12527554, DOI: 10.1152/ajprenal.00261.2002.Peer-Reviewed Original ResearchConceptsConcentrations of Ang IIAng IIProximal tubulesFluid absorptionTMB-8Effect of luminal ANGLow concentrations of Ang IIEffects of Ang IIEffects of angiotensin IIProximal tubules in vitroProximal tubule transportProximal tubules of ratsInhibit Na(+) transportIntracellular calcium mobilizationAng II concentrationsTubules of ratsCAMP-independent mechanismConcentrations of ANGNa(+) transportTubules in vitroProximal tubular fluidIntracellular Ca(2Intracellular calciumTubule transportLuminal ANG
1998
Tubule Function in Transgenic Mice
Wang T, Giebisch G. Tubule Function in Transgenic Mice. Nephron 1998, 6: 447-453. PMID: 9730661, DOI: 10.1159/000020554.Peer-Reviewed Original ResearchConceptsNa-HK-ATPaseK-ATPase expressionRenal tubule transportRenal electrolyte transportStrains of miceRenal transport functionsTransport functionColonic isoformH,K-ATPaseIsoforms NHE2Isoforms NHE1Tubule transportTubule functionTubule segmentsMouse modelTransgenic miceTransgenic knockoutTransport lesionKnockout modelsMiceKidney tubulesElectrolyte transportNull mutationTubules
1996
Effects of angiotensin II on electrolyte transport in the early and late distal tubule in rat kidney
Wang T, Giebisch G. Effects of angiotensin II on electrolyte transport in the early and late distal tubule in rat kidney. American Journal Of Physiology 1996, 271: f143-f149. PMID: 8760255, DOI: 10.1152/ajprenal.1996.271.1.f143.Peer-Reviewed Original ResearchConceptsEffects of Ang IIAng IILate distal tubuleDistal tubulesDecreased JvAngiotensin IIHigher dose of Ang IILow doses of angiotensin IILuminal application of amilorideAmiloride-sensitive Na+ transportDose of Ang IIRat kidneyHCO3- transportAddition of ANG IIDoses of angiotensin IIEffects of angiotensin IIApplication of amilorideStimulate Na+/H+ exchangeProximal tubules of rat kidneyDistal convoluted tubuleLuminal administrationNa+ channelsNa+/H+ exchangeDistal nephronIntravenous infusion
1991
The role of phosphoinositide turnover in mediating the biphasic effect of angiotensin II on renal tubular transport.
Wang T, Chan Y. The role of phosphoinositide turnover in mediating the biphasic effect of angiotensin II on renal tubular transport. Journal Of Pharmacology And Experimental Therapeutics 1991, 256: 309-17. PMID: 1846421.Peer-Reviewed Original ResearchMeSH Keywords1-(5-Isoquinolinesulfonyl)-2-MethylpiperazineAngiotensin IIAnimalsBicarbonatesBiological TransportCalcium Channel BlockersDose-Response Relationship, DrugGallic AcidIsoquinolinesKidney Tubules, ProximalMalePerfusionPhosphatidylinositolsPiperazinesProtein Kinase InhibitorsRatsRats, Inbred StrainsSignal TransductionSodiumTetradecanoylphorbol AcetateConceptsEffects of Ang IIProximal convoluted tubulesAng IITMB-8Biphasic effectAngiotensin IISodium transportStimulatory effect of Ang IIPhosphoinositide turnoverN-diethylamino)-octyl-3,4,5-trimethoxybenzoateDose-dependent biphasic effectEffects of angiotensin IIRat proximal convoluted tubuleIntracellular calcium mobilizationRenal tubular transportOriginal perfusatePerfusion in vivoIntracellular calciumNa+/H+ exchangeCalcium mobilizationJHCO3Fluid reabsorptionConvoluted tubulesLuminal perfusionRat kidney
1990
Mechanism of angiotensin II action on proximal tubular transport.
Wang T, Chan Y. Mechanism of angiotensin II action on proximal tubular transport. Journal Of Pharmacology And Experimental Therapeutics 1990, 252: 689-95. PMID: 2313594.Peer-Reviewed Original ResearchConceptsBeta-phorbol-12-myristate-13-acetateAng II actionAng IIFluid reabsorptionLow doses of angiotensin IINa-H exchange mechanismPhosphoinositide turnoverLuminal perfusionDoses of angiotensin IIAng II antagonistRat proximal tubulesProximal tubular transportAngiotensin II actionAction of angiotensinOriginal perfusatePerfusion in vivoApical membraneProximal tubulesBicarbonate absorptionAngiotensin IIJHCO3Low dosesApical sideNa-HAng