1991
The role of phosphoinositide turnover in mediating the biphasic effect of angiotensin II on renal tubular transport.
Wang T, Chan Y. The role of phosphoinositide turnover in mediating the biphasic effect of angiotensin II on renal tubular transport. Journal Of Pharmacology And Experimental Therapeutics 1991, 256: 309-17. PMID: 1846421.Peer-Reviewed Original ResearchMeSH Keywords1-(5-Isoquinolinesulfonyl)-2-MethylpiperazineAngiotensin IIAnimalsBicarbonatesBiological TransportCalcium Channel BlockersDose-Response Relationship, DrugGallic AcidIsoquinolinesKidney Tubules, ProximalMalePerfusionPhosphatidylinositolsPiperazinesProtein Kinase InhibitorsRatsRats, Inbred StrainsSignal TransductionSodiumTetradecanoylphorbol AcetateConceptsEffects of Ang IIProximal convoluted tubulesAng IITMB-8Biphasic effectAngiotensin IISodium transportStimulatory effect of Ang IIPhosphoinositide turnoverN-diethylamino)-octyl-3,4,5-trimethoxybenzoateDose-dependent biphasic effectEffects of angiotensin IIRat proximal convoluted tubuleIntracellular calcium mobilizationRenal tubular transportOriginal perfusatePerfusion in vivoIntracellular calciumNa+/H+ exchangeCalcium mobilizationJHCO3Fluid reabsorptionConvoluted tubulesLuminal perfusionRat kidney
1990
Time- and dose-dependent effects of protein kinase C on proximal bicarbonate transport
Wang T, Chan Y. Time- and dose-dependent effects of protein kinase C on proximal bicarbonate transport. The Journal Of Membrane Biology 1990, 117: 131-139. PMID: 2120446, DOI: 10.1007/bf01868680.Peer-Reviewed Original ResearchConceptsProximal convoluted tubulesProtein kinase CKinase CFluid reabsorptionPCT transportRate of bicarbonate absorptionEffects of protein kinase CActivation of endogenous protein kinase CEndogenous protein kinase CActivation of protein kinase CBicarbonate transport activityInhibition of transport processesDose-dependent effectActivate protein kinase COriginal perfusateBasolateral sideDose-response natureBicarbonate absorptionBrush-border membranePerfusion timeMaximal effectConvoluted tubulesLuminal perfusionRat kidneyRenal tubulesMechanism of angiotensin II action on proximal tubular transport.
Wang T, Chan Y. Mechanism of angiotensin II action on proximal tubular transport. Journal Of Pharmacology And Experimental Therapeutics 1990, 252: 689-95. PMID: 2313594.Peer-Reviewed Original ResearchConceptsBeta-phorbol-12-myristate-13-acetateAng II actionAng IIFluid reabsorptionLow doses of angiotensin IINa-H exchange mechanismPhosphoinositide turnoverLuminal perfusionDoses of angiotensin IIAng II antagonistRat proximal tubulesProximal tubular transportAngiotensin II actionAction of angiotensinOriginal perfusatePerfusion in vivoApical membraneProximal tubulesBicarbonate absorptionAngiotensin IIJHCO3Low dosesApical sideNa-HAng
1989
Neural control of distal tubular bicarbonate and fluid transport
Wang T, Chan Y. Neural control of distal tubular bicarbonate and fluid transport. American Journal Of Physiology 1989, 257: f72-f76. PMID: 2750926, DOI: 10.1152/ajprenal.1989.257.1.f72.Peer-Reviewed Original ResearchConceptsDistal convoluted tubuleConvoluted tubulesDistal tubulesRate of bicarbonate absorptionRenal nerve activityLate distal tubuleEarly distal tubuleTubular reabsorption of bicarbonateEffects of denervationReabsorption of bicarbonateRate of fluid absorptionNerve activityBicarbonate absorptionSham denervationElectrolyte excretionFluid reabsorptionDenervated kidneysReabsorb bicarbonateJHCO3DenervationFluid absorptionNeural regulationVolume markerTubulesMicroperfusion method