MicroRNA–mRNA networks are dysregulated in opioid use disorder postmortem brain: Further evidence for opioid-induced neurovascular alterations
Grimm S, Mendez E, Stertz L, Meyer T, Fries G, Gandhi T, Kanchi R, Selvaraj S, Teixeira A, Kosten T, Gunaratne P, Coarfa C, Walss-Bass C. MicroRNA–mRNA networks are dysregulated in opioid use disorder postmortem brain: Further evidence for opioid-induced neurovascular alterations. Frontiers In Psychiatry 2023, 13: 1025346. PMID: 36713930, PMCID: PMC9878702, DOI: 10.3389/fpsyt.2022.1025346.Peer-Reviewed Original ResearchOpioid use disorderUse disorderPostmortem brainsDorsolateral prefrontal cortexResponses to opioid drugsGenotype-Tissue ExpressionImmune system alterationsPrefrontal cortexNeurobiological alterationsBlood-brain barrierMiRNA targetsEpigenetic regulation of gene functionOpioid drugsRegulation of gene functionOpioid abuseTGF-betaGene signatureInflammatory pathwaysPotential functional impactSystem alterationsImmune systemBrain transcriptomeEndothelial cellsNeurovascular alterationsPostmortem samples