2024
Disorders due to Substance Use: General Approaches
Kosten T, Domingo C. Disorders due to Substance Use: General Approaches. 2024, 2527-2542. DOI: 10.1007/978-3-030-51366-5_92.Peer-Reviewed Original ResearchSubstance use disordersDSM-5ICD-11Depressive symptomsSubstance use disorder criteriaBorderline personality disorderSubstance-induced conditionsGoal of abstinenceDrug withdrawal symptomsPersonality disorderDepressive disorderAgonist maintenanceWithdrawal symptomsAcute detoxificationLifetime substanceSUD diagnosisAbused drugsDevelopmental differencesUrine toxicologySubstance useAlcohol usePsychosocial rehabilitationDisordersDrug useSymptomsDexmedetomidine HCL (BXCL501) as a potential treatment for alcohol use disorder and comorbid PTSD: A phase 1b, placebo‐controlled crossover laboratory study
Petrakis I, Nolen T, Vandergrift N, Hirsch S, Krystal J, De Vivo M, Sabados J, Pisani E, Newcomb J, Kosten T. Dexmedetomidine HCL (BXCL501) as a potential treatment for alcohol use disorder and comorbid PTSD: A phase 1b, placebo‐controlled crossover laboratory study. American Journal On Addictions 2024 PMID: 39152094, DOI: 10.1111/ajad.13637.Peer-Reviewed Original ResearchPathophysiology of posttraumatic stress disorderAlcohol use disorderSubjective effects of alcoholEffects of alcoholUse disorderComorbid alcohol use disorderAlcohol cue reactivityPosttraumatic stress disorderCrossover laboratory studyCue reactivityAlcohol cravingNoradrenergic dysregulationStress disorderBlood pressureSubjective effectsEthanol administrationClinically significant adverse effectsPharmacotherapeutic approachesTest daysReceptor agonistsPotential treatmentDouble-blind fashionCravingDrinking alcoholDisordersEfficacy and safety of psychedelics for the treatment of mental disorders: A systematic review and meta-analysis
Yao Y, Guo D, Lu T, Liu F, Huang S, Diao M, Li S, Zhang X, Kosten T, Shi J, Bao Y, Lu L, Han Y. Efficacy and safety of psychedelics for the treatment of mental disorders: A systematic review and meta-analysis. Psychiatry Research 2024, 335: 115886. PMID: 38574699, DOI: 10.1016/j.psychres.2024.115886.Peer-Reviewed Original ResearchConceptsMental disordersTreatment of mental disordersBorderline personality disorderObsessive-compulsive disorderTreat mood disordersSubstance-use disordersBody dysmorphic disorderPersonality disorderMood disordersDysmorphic disorderNegative moodEating disordersLasting adverse effectsTobacco addictionPsychedelicsDisordersTreat symptomsPsilocybinSleep disordersAyahuascaTherapeutic effectMeta-analyzedLSDPTSDMDMAPrediction of adverse events risk in patients with comorbid post-traumatic stress disorder and alcohol use disorder using electronic medical records by deep learning models
Miranda O, Fan P, Qi X, Wang H, Brannock M, Kosten T, Ryan N, Kirisci L, Wang L. Prediction of adverse events risk in patients with comorbid post-traumatic stress disorder and alcohol use disorder using electronic medical records by deep learning models. Drug And Alcohol Dependence 2024, 255: 111066. PMID: 38217979, PMCID: PMC10853953, DOI: 10.1016/j.drugalcdep.2023.111066.Peer-Reviewed Original ResearchConceptsPost-traumatic stress disorderAlcohol use disorderComorbid post-traumatic stress disorderStress disorderUse disorderCognitive behavioral therapyElectronic medical recordsBehavioral therapyMental disordersNeighborhood-level social determinants of healthNeighborhood-level social determinantsSocial determinants of healthArea under the receiver operating curveDeterminants of healthVeteran dataMedical recordsDisordersPsychotherapyPrediction of adverse eventsVeteran statusPatient's increased riskHigh-risk populationAnalyzed electronic medical recordsUniversity of Pittsburgh Medical CenterAdverse events
2023
Disorders Due to Substance Use: General Approaches
Kosten T, Domingo C. Disorders Due to Substance Use: General Approaches. 2023, 1-16. DOI: 10.1007/978-3-030-42825-9_92-1.Peer-Reviewed Original ResearchSubstance use disordersDSM-5ICD-11Depressive symptomsSubstance use disorder criteriaBorderline personality disorderSubstance-induced conditionsGoal of abstinenceDrug withdrawal symptomsPersonality disorderDepressive disorderAgonist maintenanceWithdrawal symptomsAcute detoxificationLifetime substanceSUD diagnosisAbused drugsDevelopmental differencesUrine toxicologySubstance useAlcohol usePsychosocial rehabilitationDisordersDrug useSymptomsNo indication of abuse potential and absence of withdrawal from esmethadone in patients with major depressive disorder
Shram M, Pappagallo M, Henningfield J, Gorodetzky C, De Martin S, Vocci F, Sapienza F, Kosten T, Bushnell D, Guidetti C, O'Gorman C, Folli F, Traversa S, Inturrisi C, Manfredi P. No indication of abuse potential and absence of withdrawal from esmethadone in patients with major depressive disorder. Neuroscience Applied 2023, 2: 102965. DOI: 10.1016/j.nsa.2023.102965.Peer-Reviewed Original Research