2012
Specific N‐glycans on SynCAM Ig proteins regulate synaptic adhesion and synapse development
Biederer T. Specific N‐glycans on SynCAM Ig proteins regulate synaptic adhesion and synapse development. The FASEB Journal 2012, 26: 232.2-232.2. DOI: 10.1096/fasebj.26.1_supplement.232.2.Peer-Reviewed Original ResearchTrans-synaptic interactionsSynapse developmentN-glycansSite-specific N-glycosylationSpecialized cell junctionsSpecific N-glycansProtein complexesFirst Ig domainN-glycosylationBinding interfaceSynaptic adhesionIg domainsFunctional analysisSynCAM 1Cell junctionsIg1 domainImmunoglobulin proteinNovel mechanismIg proteinGlycosylationProteinAdhesive interactionsSynCAMSynaptic cleftExcitatory synapses
2007
SynCAMs Organize Synapses through Heterophilic Adhesion
Fogel AI, Akins MR, Krupp AJ, Stagi M, Stein V, Biederer T. SynCAMs Organize Synapses through Heterophilic Adhesion. Journal Of Neuroscience 2007, 27: 12516-12530. PMID: 18003830, PMCID: PMC6673342, DOI: 10.1523/jneurosci.2739-07.2007.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell AdhesionCell Adhesion MoleculesCell Adhesion Molecules, NeuronalCell DifferentiationCell LineCells, CulturedCoculture TechniquesHippocampusHumansImmunoglobulinsMacromolecular SubstancesMiceNeural PathwaysPresynaptic TerminalsProtein IsoformsRatsRats, Sprague-DawleySynapsesSynaptic MembranesSynaptic TransmissionTumor Suppressor ProteinsConceptsAdhesion complexesDivergent expression profilesImmunoglobulin superfamily memberHeterophilic complexesProtein familyPosttranslational modificationsHeterophilic adhesionSuperfamily membersCell adhesion moleculeSynapse organizationExpression profilesSynapse developmentSynCAM 1Cell junctionsActive presynaptic terminalsPostsynaptic sideMolecular compositionAdhesion moleculesAdhesive patternsProteinSynaptic cleftPresynaptic terminalsComplexesExcitatory neurotransmissionFunctional synapses