2016
Spatiotemporal calibration and resolution refinement of output from deterministic models
Gilani O, McKay LA, Gregoire TG, Guan Y, Leaderer BP, Holford TR. Spatiotemporal calibration and resolution refinement of output from deterministic models. Statistics In Medicine 2016, 35: 2422-2440. PMID: 26790617, DOI: 10.1002/sim.6867.Peer-Reviewed Original ResearchConceptsGrid-cell formatCurrent calibration techniquesSpatiotemporal calibrationModeling strategyCommunity Multiscale Air Quality (CMAQ) modelAir quality modelsMultiscale Air Quality modelCalibration techniqueObserved measurementsPixel sizeSpatial resolutionGrid dataMonitoring stationsQuality modelDeterministic modelRegular gridAmbient nitrogen dioxide concentrationsDaily estimatesMeasurementsProcess of interestGridNitrogen dioxide concentrationsProcessPixelsDioxide concentration
2012
Chapter 14: Comparing the Adequacy of Carcinogenesis Models in Estimating U.S. Population Rates for Lung Cancer Mortality
Holford TR, Levy DT. Chapter 14: Comparing the Adequacy of Carcinogenesis Models in Estimating U.S. Population Rates for Lung Cancer Mortality. Risk Analysis 2012, 32: s179-s189. PMID: 22882888, PMCID: PMC3478769, DOI: 10.1111/j.1539-6924.2011.01734.x.Peer-Reviewed Original ResearchConceptsLung cancer mortalityCancer mortalityCarcinogenesis modelLung cancer mortality ratesU.S. population ratesEffect of smokingCancer Prevention StudyCancer mortality ratesPopulation ratesTwo-stage clonal expansion modelEffect of ageSmoking trendsLung cancerPrevention StudyEstimates of riskMortality rateClonal expansionClonal expansion modelCohort modelSmokingIndividual cohortsCohortMortalityU.S. malesTemporal trendsChapter 12: Yale Lung Cancer Model
Holford TR, Ebisu K, McKay L, Oh C, Zheng T. Chapter 12: Yale Lung Cancer Model. Risk Analysis 2012, 32: s151-s165. PMID: 22882886, PMCID: PMC3662537, DOI: 10.1111/j.1539-6924.2011.01754.x.Peer-Reviewed Original ResearchConceptsLung cancer deathsCarcinogenesis modelCancer deathLung cancer incidenceLung cancer modelTwo-stage clonal expansion modelCigarette smokingCancer incidenceCancer modelTobacco controlClonal expansion modelPopulation ratesCohort modelSmokingDeathHarmful effectsPopulation dataTemporal trendsMortalityObserved numberIncidenceControl