2002
Use of hair colouring products and breast cancer risk a case–control study in Connecticut
Zheng T, Holford T, Mayne S, Owens P, Boyle P, Zhang B, Zhang Y, Zahm S. Use of hair colouring products and breast cancer risk a case–control study in Connecticut. European Journal Of Cancer 2002, 38: 1647-1652. PMID: 12142056, DOI: 10.1016/s0959-8049(02)00138-7.Peer-Reviewed Original Research
2000
Joint effects of nine polychlorinated biphenyl (PCB) congeners on breast cancer risk
Holford T, Zheng T, Mayne S, Zahm S, Tessari J, Boyle P. Joint effects of nine polychlorinated biphenyl (PCB) congeners on breast cancer risk. International Journal Of Epidemiology 2000, 29: 975-982. PMID: 11101537, DOI: 10.1093/ije/29.6.975.Peer-Reviewed Original ResearchConceptsBreast cancer riskCancer riskProtective effectBreast adipose tissue samplesYale-New Haven HospitalBreast-related surgeryAdipose tissue samplesStandardized questionnaireHealth concernCYP2B inducersAdverse effectsLogistic ridge regressionTissue samplesExposure levelsSignificant differencesMajor environmental health concernRiskEnvironmental health concernsPCB congenersDioxin-like congenersJoint effectsPatientsStatistical analysisSurgeryRegressionOxychlordane and trans-nonachlor in breast adipose tissue and risk of female breast cancer.
Zheng T, Holford T, Tessari J, Mayne S, Zahm S, Owens P, Zhang B, Ward B, Carter D, Zhang Y, Zhang W, Dubrow R, Boyle P. Oxychlordane and trans-nonachlor in breast adipose tissue and risk of female breast cancer. Journal Of Cancer Epidemiology And Prevention 2000, 5: 153-60. PMID: 11051111.Peer-Reviewed Original ResearchConceptsAdipose tissue levelsBreast cancer riskFemale breast cancerBreast adipose tissueBreast cancerRisk factorsOdds ratioAdipose tissueBenign breast disease controlsFemale breast cancer riskPrimary breast cancer patientsCovariate-adjusted odds ratioEnvironmental exposuresProgesterone receptor statusBreast cancer patientsRecent epidemiological studiesMenopausal statusReceptor statusHighest quartileEpidemiological studiesCancerMajor metaboliteRiskStructured questionnaireOverall significant impact
1999
DDE and DDT in Breast Adipose Tissue and Risk of Female Breast Cancer
Zheng T, Holford T, Mayne S, Ward B, Carter D, Ownes P, Dubrow R, Zahm S, Boyle P, Archibeque S, Tessari J. DDE and DDT in Breast Adipose Tissue and Risk of Female Breast Cancer. American Journal Of Epidemiology 1999, 150: 453-458. PMID: 10472944, DOI: 10.1093/oxfordjournals.aje.a010033.Peer-Reviewed Original ResearchConceptsBreast cancer riskBreast adipose tissueTissue levelsCancer riskAdipose tissueBenign breast disease controlsIncident breast cancer casesYale-New Haven HospitalBreast-related surgeryAdipose tissue levelsFemale breast cancerCase-control studyBreast cancer casesMean tissue levelsLogistic regression modelsRank sum testHighest quartileSurgical specimenDichlorodiphenyltrichloroethane (DDT) exposureOdds ratioBreast cancerCancer casesDisease controlSum testMean levelsA Multicomponent Intervention to Prevent Delirium in Hospitalized Older Patients
Inouye S, Bogardus S, Charpentier P, Leo-Summers L, Acampora D, Holford T, Cooney L. A Multicomponent Intervention to Prevent Delirium in Hospitalized Older Patients. New England Journal Of Medicine 1999, 340: 669-676. PMID: 10053175, DOI: 10.1056/nejm199903043400901.Peer-Reviewed Original ResearchConceptsSeverity of deliriumRisk factorsCognitive impairmentRecurrence rateIntervention groupRisk factor intervention strategyHearing impairmentVisual impairmentHospitalized Older PatientsPatients 70 yearsPrevention of deliriumUsual care unitsUsual care groupGeneral medicine serviceEffective treatment strategiesDuration of episodesPrevent DeliriumOlder patientsRate of usePrimary outcomeSleep medicationPoor outcomePrimary preventionPatient's deliriumTeaching hospital
1997
Statistical evaluation of the role of Helicobacter pylori in stress gastritis: Applications of splines and bootstrapping to the logistic model
Riester K, Peduzzi P, Holford T, Ellison R, Donta S. Statistical evaluation of the role of Helicobacter pylori in stress gastritis: Applications of splines and bootstrapping to the logistic model. Journal Of Clinical Epidemiology 1997, 50: 1273-1279. PMID: 9393383, DOI: 10.1016/s0895-4356(97)00180-7.Peer-Reviewed Original ResearchConceptsStress gastritisH. pyloriHelicobacter pyloriIntensive care unit populationIntensive care unitImmunoglobulin A (IgA) concentrationsCharacteristic curve analysisCare unitGastric ulcerRisk factorsUnit populationGastritisA concentrationsPyloriCurve analysisLogistic modelImportant predictorCausal natureSpline modelUlcersRisk of tongue cancer associated with tobacco smoking and alcohol consumption: a case-control study
Zheng T, Holford T, Chen Y, Jiang P, Zhang B, Boyle P. Risk of tongue cancer associated with tobacco smoking and alcohol consumption: a case-control study. Oral Oncology 1997, 33: 82-85. PMID: 9231164, DOI: 10.1016/s0964-1955(96)00056-5.Peer-Reviewed Original ResearchConceptsTongue cancerCase-control studyTobacco smokingAlcohol drinkingRisk factorsCurrent smokersCigarette equivalentsQuitting smokingEffect modificationTobacco consumptionSmokingAlcohol consumptionNumber of casesSignificant associationCancerYoung populationRiskRecent studiesDrinkingDaysSmokersYearsStudyDiseaseWeeks
1996
A simulation study of the number of events per variable in logistic regression analysis
Peduzzi P, Concato J, Kemper E, Holford T, Feinstein A. A simulation study of the number of events per variable in logistic regression analysis. Journal Of Clinical Epidemiology 1996, 49: 1373-1379. PMID: 8970487, DOI: 10.1016/s0895-4356(96)00236-3.Peer-Reviewed Original ResearchSmoking and drinking in relation to oral epithelial dysplasia.
Morse D, Katz R, Pendrys D, Holford T, Krutchkoff D, Eisenberg E, Kosis D, Mayne S. Smoking and drinking in relation to oral epithelial dysplasia. Cancer Epidemiology Biomarkers & Prevention 1996, 5: 769-77. PMID: 8896887.Peer-Reviewed Original ResearchConceptsOral epithelial dysplasiaOdds ratioMouthwash useDenture statusRisk factorsEpithelial dysplasiaDrinks/weekAdjusted odds ratioImportant risk factorOral Pathology LaboratoryStandardized telephone interviewCase-control studyPotential risk factorsConditional logistic regressionLevel of smokingCurrent smokingAlcohol intakeIncident casesSmoking cessationOral cancerExcess riskHistopathological diagnosisSmokingAppointment dateLogistic regressionAsthma among Puerto Rican Hispanics: a multi-ethnic comparison study of risk factors.
Beckett W, Belanger K, Gent J, Holford T, Leaderer B. Asthma among Puerto Rican Hispanics: a multi-ethnic comparison study of risk factors. American Journal Of Respiratory And Critical Care Medicine 1996, 154: 894-899. PMID: 8887582, DOI: 10.1164/ajrccm.154.4.8887582.Peer-Reviewed Original ResearchConceptsRisk factorsPuerto Rican HispanicsSocioeconomic statusHispanic ethnicityHispanic mothersEnvironmental tobacco smoke exposureIndependent risk factorPhysician-diagnosed asthmaPrevalence of asthmaTobacco smoke exposureStrong risk factorAfrican American ethnicityEnvironmental risk factorsYr of ageLow socioeconomic statusStudy of asthmaNon-Hispanic whitesMo of ageActive smokingAsthmatic childrenSmoke exposureChildhood asthmaCigarette smokersMaternal ageMaternal historyMalignant melanoma risk factors by anatomic site: A case‐control study and polychotomous logistic regression analysis
Chen Y, Dubrow R, Holford T, Zheng T, Barnhill R, Fine J, Berwick M. Malignant melanoma risk factors by anatomic site: A case‐control study and polychotomous logistic regression analysis. International Journal Of Cancer 1996, 67: 636-643. PMID: 8782651, DOI: 10.1002/(sici)1097-0215(19960904)67:5<636::aid-ijc8>3.0.co;2-v.Peer-Reviewed Original ResearchConceptsMelanoma risk factorsCase-control studyRisk factorsAnatomic sitesSun exposurePopulation-based case-control studySun exposure-related factorsIntermittent sun exposureHistory of sunburnOnly risk factorPolychotomous logistic regression analysisInvasive melanoma casesNumber of neviLogistic regression analysisExposure-related factorsDevelopment of melanomaSex differencesPolychotomous logistic regressionHistologic subtypeMalignant melanomaClothing habitsPigmentary characteristicsMelanoma casesStudy subjectsLogistic regression
1993
The risk of determining risk with multivariable models.
Concato J, Feinstein A, Holford T. The risk of determining risk with multivariable models. Annals Of Internal Medicine 1993, 118: 201-10. PMID: 8417638, DOI: 10.7326/0003-4819-118-3-199302010-00009.Peer-Reviewed Original Research