Slav Bagriantsev, PhD
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Cellular & Molecular Physiology
Primary
Contact Info
Cellular & Molecular Physiology
Sterling Hall of Medicine, B-Wing, 333 Cedar St
New Haven, CT 06510
United States
About
Titles
Professor
Appointments
Cellular & Molecular Physiology
ProfessorPrimary
Other Departments & Organizations
- Biochemistry, Quantitative Biology, Biophysics and Structural Biology (BQBS)
- Cellular & Molecular Physiology
- Interdepartmental Neuroscience Program
- Molecular Medicine, Pharmacology, and Physiology
- Neuroscience Track
- Yale Combined Program in the Biological and Biomedical Sciences (BBS)
Education & Training
- Postdoc
- University of California San Francisco (2012)
- PhD
- University of Illinois at Chicago (2007)
Research
Overview
Medical Research Interests
Anseriformes; Biochemistry; Biophysics; Ducks; Electrophysiology; Ion Channels; Mechanoreceptors; Neurosciences; Pacinian Corpuscles; Potassium Channels; Sensory Receptor Cells; Thermoreceptors; Transient Receptor Potential Channels; Trigeminal Ganglion; Voltage-Gated Sodium Channels
ORCID
0000-0002-6661-3403- View Lab Website
The Slav Lab
Research at a Glance
Yale Co-Authors
Frequent collaborators of Slav Bagriantsev's published research.
Publications Timeline
A big-picture view of Slav Bagriantsev's research output by year.
Research Interests
Research topics Slav Bagriantsev is interested in exploring.
Elena Gracheva, PhD
Yury Nikolaev, MSc, PhD
Viktor Feketa
Patrick Gallagher, MD, BS
C. Shan Xu, PhD
Madeleine Junkins
34Publications
687Citations
Ion Channels
Ducks
Mechanoreceptors
Trigeminal Ganglion
Sensory Receptor Cells
Thermoreceptors
Publications
Featured Publications
Mechanotransduction events at the physiological site of touch detection
Ziolkowski L, Gracheva E, Bagriantsev S. Mechanotransduction events at the physiological site of touch detection. ELife 2023, 12: e84179. PMID: 36607222, PMCID: PMC9833821, DOI: 10.7554/elife.84179.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsSensational channels
Gracheva EO, Bagriantsev SN. Sensational channels. Cell 2021, 184: 6213-6216. PMID: 34942094, DOI: 10.1016/j.cell.2021.11.034.Peer-Reviewed Original ResearchCitationsAltmetricLamellar cells in Pacinian and Meissner corpuscles are touch sensors
Nikolaev YA, Feketa VV, Anderson EO, Schneider ER, Gracheva EO, Bagriantsev SN. Lamellar cells in Pacinian and Meissner corpuscles are touch sensors. Science Advances 2020, 6: eabe6393. PMID: 33328243, PMCID: PMC7744075, DOI: 10.1126/sciadv.abe6393.Peer-Reviewed Original ResearchCitationsAltmetricConceptsLamellar cellsR-type voltage-gated calcium channelsMeissner corpusclesAction potentialsChannel-dependent action potentialsPacinian corpusclesVoltage-gated calcium channelsSensory afferent neuronsNon-neuronal cellsBill skinAfferent neuronsNeuronal afferentsCalcium channelsElectrophysiological recordingsTactile stimuliCorpusclesIon channelsCellsSkinFirst evidenceTactile organsAfferentsNeuronsPiezo2 Integrates Mechanical and Thermal Cues in Vertebrate Mechanoreceptors
Nikolaev Y, Zheng W, Gracheva E, Bagriantsev S. Piezo2 Integrates Mechanical and Thermal Cues in Vertebrate Mechanoreceptors. Biophysical Journal 2020, 118: 396a. DOI: 10.1016/j.bpj.2019.11.2254.Peer-Reviewed Original ResearchAltmetricPiezo2 integrates mechanical and thermal cues in vertebrate mechanoreceptors
Zheng W, Nikolaev YA, Gracheva EO, Bagriantsev SN. Piezo2 integrates mechanical and thermal cues in vertebrate mechanoreceptors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2019, 116: 17547-17555. PMID: 31413193, PMCID: PMC6717272, DOI: 10.1073/pnas.1910213116.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsA Cross-Species Analysis Reveals a General Role for Piezo2 in Mechanosensory Specialization of Trigeminal Ganglia from Tactile Specialist Birds
Schneider ER, Anderson EO, Feketa VV, Mastrotto M, Nikolaev YA, Gracheva EO, Bagriantsev SN. A Cross-Species Analysis Reveals a General Role for Piezo2 in Mechanosensory Specialization of Trigeminal Ganglia from Tactile Specialist Birds. Cell Reports 2019, 26: 1979-1987.e3. PMID: 30784581, PMCID: PMC6420409, DOI: 10.1016/j.celrep.2019.01.100.Peer-Reviewed Original ResearchAltmetricMeSH Keywords and ConceptsConceptsTrigeminal ganglionPiezo2 ion channelsExpression of moleculesExpression of factorsPiezo2 expressionSomatosensory neuronsNeuronal subtypesSomatosensory systemSuch neuronsSpecialist birdsBird speciesMolecular variationFamily AnatidaeForaging behaviorTactile specializationNeuronsMechanoreceptorsSpecies analysisGangliaGeneral roleBehavioral phenotypesIon channelsGeneral mechanismTactile specialistsFunction of mechanoreceptors3D architecture and a bicellular mechanism of touch detection in mechanosensory corpuscle
Nikolaev Y, Ziolkowski L, Pang S, Li W, Feketa V, Xu C, Gracheva E, Bagriantsev S. 3D architecture and a bicellular mechanism of touch detection in mechanosensory corpuscle. Science Advances 2023, 9: eadi4147. PMID: 37703368, PMCID: PMC10499330, DOI: 10.1126/sciadv.adi4147.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2024
Hypothalamic hormone deficiency enables physiological anorexia in ground squirrels during hibernation
Mohr S, Dai Pra R, Platt M, Feketa V, Shanabrough M, Varela L, Kristant A, Cao H, Merriman D, Horvath T, Bagriantsev S, Gracheva E. Hypothalamic hormone deficiency enables physiological anorexia in ground squirrels during hibernation. Nature Communications 2024, 15: 5803. PMID: 38987241, PMCID: PMC11236985, DOI: 10.1038/s41467-024-49996-2.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsHypothalamic feeding centersHormone deficiencyHypothalamic arcuate nucleus neuronsArcuate nucleus neuronsThyroid hormone deficiencyFeeding centerEffects of ghrelinAnorexigenic effectNucleus neuronsPhysiological anorexiaThyroid hormonesNormal physiological functionsGround squirrelsInterbout arousalAnorexiaThirteen-lined ground squirrelsProlonged periodReduced sensitivityPhysiological functionsDeficiencyFrequency-modulated timer regulates torpor–arousal cycles during hibernation in distinct small mammalian hibernators
Gibo S, Yamaguchi Y, Gracheva E, Bagriantsev S, Tokuda I, Kurosawa G. Frequency-modulated timer regulates torpor–arousal cycles during hibernation in distinct small mammalian hibernators. Npj Biological Timing And Sleep 2024, 1: 3. DOI: 10.1038/s44323-024-00002-4.Peer-Reviewed Original ResearchAltmetricConceptsTorpor-arousal cycleMolecular mechanisms of hibernationMammalian hibernationGround squirrelsHibernation patternsTb fluctuationsBiological processesHarsh seasonsHibernating speciesDeep torporMolecular mechanismsConstant laboratory conditionsSyrian hamstersHibernationTB dataEndogenous periodEuthermic levelsTorporPhysiological conditionsMechanisms of hibernationBasal metabolismAmbient levelsCircannual rhythmPeriods of arousalSquirrelsNeural control of fluid homeostasis is engaged below 10°C in hibernation
Junkins M, Feng N, Murphy L, Curtis G, Merriman D, Bagriantsev S, Gracheva E. Neural control of fluid homeostasis is engaged below 10°C in hibernation. Current Biology 2024, 34: 923-930.e5. PMID: 38325375, PMCID: PMC11232715, DOI: 10.1016/j.cub.2024.01.035.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAntidiuretic hormone arginine vasopressinSupraoptic nucleusFluid homeostasisC-Fos immunohistochemistryControl of fluid homeostasisHeart rateHypothalamic supraoptic nucleusReduced plasma levelsHormone arginine vasopressinPlasma hormone levelsSlow heart rateSON neuronsArginine vasopressinMassive fluid lossPlasma levelsPosterior pituitaryHormone levelsFiber photometryC-fosBlood pressureNeuronal activityHormonal responsesThirteen-lined ground squirrelsOxytocinInterbout arousal
Academic Achievements & Community Involvement
activity Yale Science Outreach
Public ServiceCoordinatorDetailsYale S.C.H.O.L.A.R. programhonor CAREER Award
National AwardNational Science FoundationDetails05/15/2015United Stateshonor Scientist Development Grant
National AwardAmerican Heart AssociationDetails01/01/2014United Stateshonor Post-doctoral Fellowship
National AwardGenentech Foundation and the Life Sciences Research FoundationDetails01/01/2009United Stateshonor Pre-doctoral Fellowship
National AwardAmerican Heart AssociationDetails01/01/2006United States
News
News
- November 28, 2024Source: Popular Science
How hibernating squirrels go more than six months without water—and don’t get thirsty
- September 13, 2023
Researchers Map the 3D Structure of Touch Receptors and Reveal New Mechanism of Touch Detection
- April 22, 2020Source: Ni Feng receives a 2020 Warren Alpert Distinguished Scholar award
Ni Feng receives a 2020 Warren Alpert Distinguished Scholar Award
- January 09, 2020
Cellular and Molecular Physiology Annual Retreat 2019
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Mailing Address
Cellular & Molecular Physiology
Sterling Hall of Medicine, B-Wing, 333 Cedar St
New Haven, CT 06510
United States
Locations
Sterling Hall of Medicine, B-Wing
Lab
333 Cedar Street, Ste Room 133
New Haven, CT 06510
Sterling Hall of Medicine, B-Wing
Academic Office
333 Cedar Street, Ste Room 142
New Haven, CT 06510