2018
Nanotopographical regulation of pancreatic islet-like cluster formation from human pluripotent stem cells using a gradient-pattern chip
Kim J, Park B, Kim S, Lee D, Lee G, Kim D, Choi B, Lee K, Kim J. Nanotopographical regulation of pancreatic islet-like cluster formation from human pluripotent stem cells using a gradient-pattern chip. Acta Biomaterialia 2018, 95: 337-347. PMID: 30529081, DOI: 10.1016/j.actbio.2018.12.011.Peer-Reviewed Original ResearchConceptsHuman pluripotent stem cellsPancreatic islet-like clustersStem cell fatePluripotent stem cellsIslet-like clustersCell fateSpecific functional cell typesCell typesPancreatic endocrine progenitorsStem cellsStem cell nichePancreatic islet developmentFunctional cell typesSpecific cell typesPancreatic cellsDevelopmental regulatorsEndocrine progenitorsCell nicheMechanical cuesPancreatic β-cellsPolyhormonal cells
2015
Pancreatic Islet-Like Three-Dimensional Aggregates Derived From Human Embryonic Stem Cells Ameliorate Hyperglycemia in Streptozotocin-Induced Diabetic Mice
Shim J, Kim J, Han J, An S, Jang Y, Son J, Woo D, Kim S, Kim J. Pancreatic Islet-Like Three-Dimensional Aggregates Derived From Human Embryonic Stem Cells Ameliorate Hyperglycemia in Streptozotocin-Induced Diabetic Mice. Cell Transplantation 2015, 24: 2155-2168. PMID: 25397866, DOI: 10.3727/096368914x685438.Peer-Reviewed Original ResearchConceptsDiabetic miceHuman embryonic stem cellsClinical islet transplantationBlood glucose levelsMature pancreatic endocrine cellsPancreatic endocrine cellsStem cellsInhibition of NotchAmeliorate hyperglycemiaIslet transplantationPancreatic hormonesGlucose levelsPancreatic endodermDonor isletsPancreatic featuresActivin APharmacological drugsEndocrine cellsIncreased expressionThree-dimensional aggregatesExpression of Neurog3Transient upregulationProgenitor cellsRetinoic acidActivin βB