2011
Direct and Indirect Contribution of Human Embryonic Stem Cell–Derived Hepatocyte-Like Cells to Liver Repair in Mice
Woo D, Kim S, Lim H, Heo J, Park H, Kang G, Kim S, You H, Hoeppner D, Kim Y, Kwon H, Choi T, Lee J, Hong S, Song K, Ahn E, Chenoweth J, Tesar P, McKay R, Kim J. Direct and Indirect Contribution of Human Embryonic Stem Cell–Derived Hepatocyte-Like Cells to Liver Repair in Mice. Gastroenterology 2011, 142: 602-611. PMID: 22138358, DOI: 10.1053/j.gastro.2011.11.030.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkersCarbon TetrachlorideCell DifferentiationCell ProliferationCell SeparationCells, CulturedChemical and Drug Induced Liver InjuryCoculture TechniquesDisease Models, AnimalEmbryonic Stem CellsHepatocytesHumansImmunohistochemistryInduced Pluripotent Stem CellsLaser Capture MicrodissectionLithium ChlorideLiverLiver RegenerationMass SpectrometryMiceMice, Inbred BALB CMice, NudeMicroscopy, ElectronNeovascularization, PhysiologicPolymerase Chain ReactionProteomicsTime FactorsWound HealingConceptsHepatocyte-like cellsLiver repairLiver tissueCell replacementEndogenous liver regenerationAcute liver injuryDirect cell replacementHost liver tissueStem cellsLiver of miceIndocyanine green stainingHuman embryonic stem cell-derived cellsEmbryonic stem cell-derived cellsCell-derived signalsHost tissue repairStem cell-derived cellsStem cell-derived hepatocyte-like cellsCell-derived hepatocyte-like cellsLiver injuryCell-derived cellsPolymerase chain reactionCell graftsIntraperitoneal injectionHepatic featuresTrophic factors
2009
Differentiation of Neural Progenitor Cells in a Microfluidic Chip‐Generated Cytokine Gradient
Park J, Kim S, Woo D, Lee E, Kim J, Lee S. Differentiation of Neural Progenitor Cells in a Microfluidic Chip‐Generated Cytokine Gradient. Stem Cells 2009, 27: 2646-2654. PMID: 19711444, DOI: 10.1002/stem.202.Peer-Reviewed Original ResearchConceptsCell typesNeural progenitorsHuman embryonic stem cellsEarly embryonic developmentStem cellsEmbryonic stem cellsCytokine gradientsEnriched populationNeural progenitor cellsPrimitive stem cellsEmbryonic developmentSignaling moleculesDiverse tissuesCell body clustersProgenitor cellsNeurite bundlesGrowth factorProgenitorsCell-friendly microenvironmentCellsDifferentiationExogenous cytokinesImportant roleBody clustersSpatial gradients
2008
Inhibitory Effect of Tributyltin on Expression of Steroidogenic Enzymes in Mouse Testis
Kim S, Kim J, Han J, Yoon Y. Inhibitory Effect of Tributyltin on Expression of Steroidogenic Enzymes in Mouse Testis. International Journal Of Toxicology 2008, 27: 175-182. PMID: 18404541, DOI: 10.1080/10915810801977906.Peer-Reviewed Original ResearchConceptsInterstitial Leydig cellsSteroidogenic enzymesLeydig cellsImmature male miceSerum testosterone concentrationsTesticular developmentInhibition of steroidogenesisCholesterol side-chain cleavage enzymeSide-chain cleavage enzymeSteroid hormone productionGerm cellsTesticular germ cellsApoptotic germ cellsOral gavageMale miceSingle administrationTestosterone concentrationsHormone productionInhibitory effectSeminiferous tubulesAdverse effectsInduced apoptosisTBT exposureAcute toxicityCleavage enzyme