2020
Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs
Burke EE, Chenoweth JG, Shin JH, Collado-Torres L, Kim SK, Micali N, Wang Y, Colantuoni C, Straub RE, Hoeppner DJ, Chen HY, Sellers A, Shibbani K, Hamersky GR, Diaz Bustamante M, Phan BN, Ulrich WS, Valencia C, Jaishankar A, Price AJ, Rajpurohit A, Semick SA, Bürli RW, Barrow JC, Hiler DJ, Page SC, Martinowich K, Hyde TM, Kleinman JE, Berman KF, Apud JA, Cross AJ, Brandon NJ, Weinberger DR, Maher BJ, McKay RDG, Jaffe AE. Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs. Nature Communications 2020, 11: 462. PMID: 31974374, PMCID: PMC6978526, DOI: 10.1038/s41467-019-14266-z.Peer-Reviewed Original ResearchConceptsHuman induced pluripotent stem cellsNeural precursor cellsExpression dataSingle-cell expression dataNeuronal differentiationSequencing read alignmentsInduced pluripotent stem cellsEarly neuronal differentiationPluripotent stem cellsTranscriptomic resourcesIPSC donorNeuronal culturesSubclonal linesNeural differentiationTranscriptomic signaturesHuman neural precursor cellsNeuronal cellsStem cellsPrecursor cellsCell sortingGlobal patternsPowerful modelSubset of neuronsRead alignmentDifferentiation
2011
Direct and Indirect Contribution of Human Embryonic Stem Cell–Derived Hepatocyte-Like Cells to Liver Repair in Mice
Woo D, Kim S, Lim H, Heo J, Park H, Kang G, Kim S, You H, Hoeppner D, Kim Y, Kwon H, Choi T, Lee J, Hong S, Song K, Ahn E, Chenoweth J, Tesar P, McKay R, Kim J. Direct and Indirect Contribution of Human Embryonic Stem Cell–Derived Hepatocyte-Like Cells to Liver Repair in Mice. Gastroenterology 2011, 142: 602-611. PMID: 22138358, DOI: 10.1053/j.gastro.2011.11.030.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiomarkersCarbon TetrachlorideCell DifferentiationCell ProliferationCell SeparationCells, CulturedChemical and Drug Induced Liver InjuryCoculture TechniquesDisease Models, AnimalEmbryonic Stem CellsHepatocytesHumansImmunohistochemistryInduced Pluripotent Stem CellsLaser Capture MicrodissectionLithium ChlorideLiverLiver RegenerationMass SpectrometryMiceMice, Inbred BALB CMice, NudeMicroscopy, ElectronNeovascularization, PhysiologicPolymerase Chain ReactionProteomicsTime FactorsWound HealingConceptsHepatocyte-like cellsLiver repairLiver tissueCell replacementEndogenous liver regenerationAcute liver injuryDirect cell replacementHost liver tissueStem cellsLiver of miceIndocyanine green stainingHuman embryonic stem cell-derived cellsEmbryonic stem cell-derived cellsCell-derived signalsHost tissue repairStem cell-derived cellsStem cell-derived hepatocyte-like cellsCell-derived hepatocyte-like cellsLiver injuryCell-derived cellsPolymerase chain reactionCell graftsIntraperitoneal injectionHepatic featuresTrophic factors
2006
Nonylphenol and Octylphenol-Induced Apoptosis in Human Embryonic Stem Cells Is Related to Fas-Fas Ligand Pathway
Kim S, Kim B, Shim J, Gil J, Yoon Y, Kim J. Nonylphenol and Octylphenol-Induced Apoptosis in Human Embryonic Stem Cells Is Related to Fas-Fas Ligand Pathway. Toxicological Sciences 2006, 94: 310-321. PMID: 16984955, DOI: 10.1093/toxsci/kfl114.Peer-Reviewed Original ResearchConceptsHuman embryonic stem cellsUndifferentiated hES cellsEmbryonic stem cellsHES cellsNeural progenitor cellsEarly embryonic developmentStem cellsProgenitor cellsToxic stress responseChemical-induced apoptosisFas ligand protein expressionFas-Fas ligand pathwayCell replacement therapyEmbryonic developmentCaspase activationES cellsCaspase-8Stress responseDevelopmental stagesDNA fragmentationCell typesFas-FasL interactionCommon environmental contaminantsApoptosisProtein expression