2007
Octylphenol reduces the expressions of steroidogenic enzymes and testosterone production in mouse testis
Kim S, Kim J, Lee H, Yoon Y. Octylphenol reduces the expressions of steroidogenic enzymes and testosterone production in mouse testis. Environmental Toxicology 2007, 22: 449-458. PMID: 17696135, DOI: 10.1002/tox.20280.Peer-Reviewed Original ResearchConceptsTestosterone productionSteroidogenic enzymesLeydig cellsMale miceTestosterone concentrationsJuvenile exposureDecreased testosterone productionAltered cholesterol metabolismSerum testosterone concentrationsAdult male micePositive Leydig cellsCholesterol side-chain cleavage enzymeCholesterol transport genesSide-chain cleavage enzymeInterstitial Leydig cellsSteroidogenic acute regulatory proteinAlteration of steroidogenesisPresent studyAcute regulatory proteinEstradiol valerateInhibits steroidogenesisCholesterol metabolismRT-PCR analysisP450scc proteinPotential mechanisms
2004
PREPUBERTAL EXPOSURE TO 4-TERT-OCTYLPHENOL INDUCES APOPTOSIS OF TESTICULAR GERM CELLS IN ADULT RAT
KIM S, LEE H, YANG H, KIM H, YOON Y. PREPUBERTAL EXPOSURE TO 4-TERT-OCTYLPHENOL INDUCES APOPTOSIS OF TESTICULAR GERM CELLS IN ADULT RAT. Systems Biology In Reproductive Medicine 2004, 50: 427-441. PMID: 15669608, DOI: 10.1080/01485010490475093.Peer-Reviewed Original ResearchConceptsTesticular germ cellsEstradiol valerateSerum LH concentrationsSerum testosterone concentrationsGerm cellsWeek old ratsPrepubertal male ratsLH concentrationsMale reproductive organsMale ratsTestosterone concentrationsAdult ratsOld ratsChronic exposureMarked reductionSeminiferous tubulesRatsSeminal vesiclesBcl-2Decreased biosynthesisBax mRNAThree timesTesticular developmentBcl-xL mRNAApoptosis