2020
Moderation of Prazosin’s Efficacy by Alcohol Withdrawal Symptoms
Sinha R, Wemm S, Fogelman N, Milivojevic V, Morgan PM, Angarita GA, Hermes G, Fox HC. Moderation of Prazosin’s Efficacy by Alcohol Withdrawal Symptoms. American Journal Of Psychiatry 2020, 178: 447-458. PMID: 33207935, PMCID: PMC8119326, DOI: 10.1176/appi.ajp.2020.20050609.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic alpha-1 Receptor AntagonistsAdultAlcohol AbstinenceAlcoholismAnxietyCentral Nervous System DepressantsCounselingCravingDepressionDouble-Blind MethodEthanolFemaleHumansMaleMiddle AgedPrazosinProof of Concept StudySelf-Help GroupsSleep Wake DisordersSubstance Withdrawal SyndromeTreatment OutcomeConceptsAlcohol withdrawal symptomsHeavy drinking daysAlcohol use disorderDrinks/dayWithdrawal symptomsDrinking daysSecondary outcomesPrazosin efficacyAlcohol cravingSelf-reported drinking daysTreatment of AUDEfficacy of prazosinWithdrawal symptom scoresPoor treatment outcomesGlobal disease burdenCurrent alcohol dependencePrimary outcomeTreat analysisAlcohol use outcomesAlcohol intakeSymptom scoresWeek 12Prognostic indicatorDisease burdenSleep disturbances
2018
Predictors of Topiramate Tolerability in Heavy Cannabis–Using Adolescents and Young Adults
Gray JC, Padovano H, Wemm SE, Miranda R. Predictors of Topiramate Tolerability in Heavy Cannabis–Using Adolescents and Young Adults. Journal Of Clinical Psychopharmacology 2018, 38: 134-137. PMID: 29424802, PMCID: PMC5825284, DOI: 10.1097/jcp.0000000000000843.Peer-Reviewed Original ResearchConceptsMemory difficultiesCannabis misuseYoung adultsPsychosocial treatment optionsSubstance use disordersPsychosocial interventionsCannabis problemsHeavy cannabisTreatment dropoutOverwhelming predictorPositive outcomesUse disordersEffective interventionsAdolescentsSide effectsMedication conditionRandomized placebo-controlled trialInteraction effectsSubstance abuse treatment admissionsTreatment admissionsPlacebo-controlled trialSecondary data analysisRecent clinical trialsIllicit drugsAdultsReal-time assessment of alcohol craving and naltrexone treatment responsiveness in a randomized clinical trial
Miranda R, Treloar Padovano H, Gray JC, Wemm SE, Blanchard A. Real-time assessment of alcohol craving and naltrexone treatment responsiveness in a randomized clinical trial. Addictive Behaviors 2018, 83: 72-78. PMID: 29395188, PMCID: PMC5964002, DOI: 10.1016/j.addbeh.2018.01.009.Peer-Reviewed Original Research