2024
Dendritic cells in a pinch: Migration during homeostasis.
Olson E, Eisenbarth S. Dendritic cells in a pinch: Migration during homeostasis. Science Immunology 2024, 9: eadt3806. PMID: 39365873, DOI: 10.1126/sciimmunol.adt3806.Peer-Reviewed Original ResearchConceptsDendritic cellsScaleable production of highly loaded protein nanoparticles for immune modulation
Caplan M, Baldwin R, Yin X, Grishin A, Eisenbarth S, Sampson H, Bottomly K, Prud’homme R. Scaleable production of highly loaded protein nanoparticles for immune modulation. Communications Materials 2024, 5: 191. DOI: 10.1038/s43246-024-00626-w.Peer-Reviewed Original ResearchAdjuvants to antigen-presenting cellsImmune modulationAntigen-presenting cellsMurine immune systemImmune system cellsPeanut-allergic patientsDesensitizer applicationPLG nanoparticlesAntigen deliverySystemic exposurePoly(lactide-co-glycolideBasophil activationClinical investigationAllergic responsesImmune systemSystem cellsProtein antigensClinical applicationDelivery of proteinsE. coli phospholipidsSafety evidenceAntigenProtein nanoparticlesDeliveryCellsAll roads lead to IgA: Mapping the many pathways of IgA induction in the gut
Siniscalco E, Williams A, Eisenbarth S. All roads lead to IgA: Mapping the many pathways of IgA induction in the gut. Immunological Reviews 2024, 326: 66-82. PMID: 39046160, DOI: 10.1111/imr.13369.Peer-Reviewed Original ResearchIgA inductionFood allergyFood-specific IgE.Food-specific IgEAntibody isotypesPrevalence of food allergyT cell helpIncreasing prevalence of food allergyRelease of histamineFoodFood antigensB cellsInduce toleranceAdverse reactionsCommensal bacteriaMast cellsIncreased prevalenceGut immunityIgAGutAllergyAntibodiesIsotypeInductionHuman red blood cells express the RNA sensor TLR7
Metthew Lam L, Oatman E, Eckart K, Klingensmith N, Flowers E, Sayegh L, Yuen J, Clements R, Meyer N, Jurado K, Vaughan A, Eisenbarth S, Mangalmurti N. Human red blood cells express the RNA sensor TLR7. Scientific Reports 2024, 14: 15789. PMID: 38982195, PMCID: PMC11233670, DOI: 10.1038/s41598-024-66410-5.Peer-Reviewed Original ResearchDendritic cells in food allergy, treatment, and tolerance
Liu E, Yin X, Siniscalco E, Eisenbarth S. Dendritic cells in food allergy, treatment, and tolerance. Journal Of Allergy And Clinical Immunology 2024, 154: 511-522. PMID: 38971539, PMCID: PMC11414995, DOI: 10.1016/j.jaci.2024.06.017.Peer-Reviewed Original ResearchAntigen presenting cellsDendritic cellsFood allergyOral tolerancePresenting cellsAllergic sensitizationPeripheral T regulatory cellsDevelopment of oral toleranceGut dendritic cellsT regulatory cellsDendritic cell subsetsLimited treatment optionsAdaptive immune responsesFood immunotherapyEpicutaneous immunotherapyCell subsetsTolerogenic programAlarmin releaseTreatment optionsLangerhans cellsFood toleranceInnocuous antigensSurface markersInflammatory conditionsImmune responseDefining and targeting mechanisms of eosinophilic inflammation in a new era of severe asthma treatment
Boyce J, Eisenbarth S. Defining and targeting mechanisms of eosinophilic inflammation in a new era of severe asthma treatment. Journal Of Clinical Investigation 2024, 134: e182410. PMCID: PMC11178525, DOI: 10.1172/jci182410.Peer-Reviewed Original ResearchThe aMPPle differentiation potential of TH2 cells in human allergy.
Siddapureddy S, Eisenbarth S. The aMPPle differentiation potential of TH2 cells in human allergy. Science Immunology 2024, 9: eadq7287. PMID: 38848341, DOI: 10.1126/sciimmunol.adq7287.Peer-Reviewed Original ResearchDOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells.
Williams A, Siniscalco E, Grassmann J, Craft J, Eisenbarth S, Uthaman G. DOCK8 and STAT3 cooperate to restrain IgE-inducing T follicular helper cells. The Journal Of Immunology 2024, 212: 0620_4120-0620_4120. DOI: 10.4049/jimmunol.212.supp.0620.4120.Peer-Reviewed Original ResearchPeanut-specific IgET cellsSpecific IgEFood allergyT follicular helper cellsCD4+ T cellsDOCK8-deficient patientsFood-specific IgEPeanut-specific IgE.Human T cellsCells in vitroDifferentiation in vivoSevere food allergyTfh cellsRegulatory populationsOvercome toleranceHelper cellsDeficient patientsSpecific IgE.DOCK8IgE productionSTAT3 mutationsMiceCholera toxinIgEFood Matrix Composition Affects the Allergenicity of Baked Egg Products
Liu E, Tan J, Munoz J, Shabanova V, Eisenbarth S, Leeds S. Food Matrix Composition Affects the Allergenicity of Baked Egg Products. The Journal Of Allergy And Clinical Immunology In Practice 2024, 12: 2111-2117. PMID: 38670261, DOI: 10.1016/j.jaip.2024.04.032.Peer-Reviewed Original ResearchEgg allergensEgg productionFood matricesExtract ovalbuminFood matrix compositionAllergenicity of eggBaked eggMuffin recipeQuantify ovalbuminRice muffinsRice flourWheat flourBlocking ELISAWheat muffinsFood ingredientsMuffinsHeated eggEgg proteinsEgg-allergic patientsWheatEggsFood allergic reactionsReduced allergenicityFlourFoodIn a wild germinal center, what determines survival of the fittest?
Flowers E, Eisenbarth S. In a wild germinal center, what determines survival of the fittest? Science Immunology 2024, 9: eadn7535. PMID: 38181096, DOI: 10.1126/sciimmunol.adn7535.Peer-Reviewed Original ResearchNovel and emerging tests for food allergy
Liu E, Eisenbarth S. Novel and emerging tests for food allergy. 2024, 698-709. DOI: 10.1016/b978-0-323-96018-2.00081-x.Peer-Reviewed Original ResearchFood allergyActivation testingSkin prick testingRisk of developmentAvailable clinical testsSkin barrier permeabilityLow predictive valueInflammatory markersPrick testingIgE testingImmunoglobulin EBarrier permeabilityAllergyPromising biomarkerPredictive valueClinical testsGenetic testingLack of testingCellular profilingMarkersWidespread useTestingImmunoglobulinBiomarkersSeverity
2023
Metabolic fitness of IgA+ plasma cells in the gut requires DOCK8
Zhang B, Chen S, Yin X, McBride C, Gertie J, Yurieva M, Bielecka A, Hoffmann B, Hinson J, Grassmann J, Xu L, Siniscalco E, Soldatenko A, Hoyt L, Joseph J, Norton E, Uthaman G, Palm N, Liu E, Eisenbarth S, Williams A. Metabolic fitness of IgA+ plasma cells in the gut requires DOCK8. Mucosal Immunology 2023, 17: 431-449. PMID: 38159726, DOI: 10.1016/j.mucimm.2023.12.001.Peer-Reviewed Original ResearchPlasma cellsLamina propriaT cell-dependent antigensCytokinesis 8 (DOCK8) mutationsDOCK8-deficient miceMucosal IgA productionRecurrent gastrointestinal infectionGut lamina propriaPoor antibody responseIgA class switchingAntigen-specific IgAEarly B cell activationLong-term survivalB cell activationGut IgAFood antigensAntibody responseIgA productionImmune homeostasisGastrointestinal infectionsPrimary immunodeficiencyT cellsPC compartmentB cellsCell activation
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