Stephan Ariyan, MD, MBA
Frank F. Kanthak Professor Emeritus of SurgeryCards
Appointments
Contact Info
About
Titles
Frank F. Kanthak Professor Emeritus of Surgery
Biography
Dr. Stephan Ariyan is the Frank F. Kanthak Professor Emeritus of Surgery, Plastic Surgery, Surgical Oncology, and Otolaryngology at Yale University School of Medicine.
He received his medical degree from New York Medical College and completed his training in general surgery as well as plastic surgery at Yale, becoming certified by both the American Board of Surgery and the American Board of Plastic Surgery. He was then asked to join the faculty at Yale in 1976, was promoted to Associate Professor in 2 years, appointed Chief of the Division of Plastic and Reconstructive Surgery in the 3rd year, and rose to the rank of tenured full Professor in another 2 years.
He served as Associate Chief of the Department of Surgery from 2007-2013.
In 1976 he founded the Yale Melanoma Program, the first multidisciplinary team at the Yale Cancer Center, and served as its Director until his retirement in 2017.
Dr. Ariyan is an internationally known surgeon specializing in the treatment of patients with head and neck cancer, breast cancer, and malignant melanoma. He has been recognized for the origination and development of several myocutaneous flaps for reconstructions of the head and neck- most notably the Pectoralis Major Flap, which has become the most commonly used flap for head and neck reconstruction worldwide. He established the Microsurgery Service at Yale in 1976, performing the first replantations of fingers and free flaps in Connecticut. He developed and performed the first composite microvascular free flap reconstruction of the jaw using the anterior vascular supply to the rib, and proved with fluorochrome markers that bone can be transferred on its periosteal blood supply.
Following the devastating earthquake in Armenia in December 1988, he was asked by the government of the then Soviet Union to help care for the many victims. During that visit, and after meeting with the Minister of Health, he noted the absence of trained reconstructive surgeons in Armenia. He therefore selected a team of surgeons, anesthesiologists, and nurses from Armenia, which he trained at Yale from 1990-1991, with the joint collaborative efforts of the USAID, the ECFMG, the RRC for Plastic Surgery, the Yale School of Medicine, and the Yale-New Haven Hospital. That team returned to Armenia in 1992, formed the Armenian Board of Plastic Surgeons, and established a certifying examination for the many plastic surgeons they have trained. The success of this effort has been cited by the USAID as the model for the implementation of health care education in the redevelopment of other countries. He was recognized for this service by a Presidential Award of the Republic of Armenia.
He has served as Vice-Chairman of the American Board of Plastic Surgery, President of 6 national surgical societies, and Founding President of the American Council of Educators in Plastic Surgery. Dr. Ariyan has been awarded numerous recognitions including the Medal of Honor from New York Medical College, the Scholar Award from the American College of Surgeons, the Presidential Award from the Society of Head and Neck Surgeons, the Presidential Citation from the American Head and Neck Society, the Lifetime Achievement Award from the New England Society of Plastic and Reconstructive Surgeons, and the Albert Nelson Marquis Lifetime Achievement Award from Marquis Who’s Who.
He has authored or co-authored more than 300 scientific papers, and five surgical books (one of them, The Hand Book, has been published in three editions in English, Spanish, and Japanese). He has served on the editorial boards of two surgical journals. He is the Founding Editor-in-Chief of Yale Surgical Videos.
His former residents have honored him with the endowed ARIYAN LECTURESHIP for an annual lecture in the Department of Surgery.
Appointments
Plastic & Reconstructive Surgery
EmeritusPrimary
Other Departments & Organizations
- Cancer Immunology
- Plastic & Reconstructive Surgery
- Surgery
Education & Training
- MBA
- University of New Haven (1993)
- UICC Fellowship
- Sydney University (1981)
- Plastic Surgery Residency
- Yale University School of Medicine (1976)
- Hand Surgery Fellowship
- Yale University School of Medicine (1976)
- General Surgery Residency
- Yale University School of Medicine (1975)
- NIH Cancer Fellowship
- Yale University School of Medicine (1971)
- Residency
- University of California - San Diego (1968)
- Surgical Internship
- UCLA-HGH (1967)
- MD
- New York Medical College (1966)
- BS
- Long Island University-University Center (1962)
Board Certifications
Surgery General
- Certification Organization
- AB of Surgery
- Original Certification Date
- 1978
Surgery Plastic
- Certification Organization
- AB of Plastic Surgery
- Original Certification Date
- 1977
Research
Overview
Medical Research Interests
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Harriet Kluger, MD
Kelly Olino, MD, FACS
Ruth Halaban, PhD
Jean Bolognia, MD
Noffar Bar, MD
Pradeep Mutalik, MD
Neoplasms
Publications
2024
Immunotherapy utilization in stage IIIA melanoma: less may be more
Frey A, Kerekes D, Khan S, Tran T, Kluger H, Clune J, Ariyan S, Sznol M, Ishizuka J, Olino K. Immunotherapy utilization in stage IIIA melanoma: less may be more. Frontiers In Oncology 2024, 14: 1336441. PMID: 38380358, PMCID: PMC10876869, DOI: 10.3389/fonc.2024.1336441.Peer-Reviewed Original ResearchCitationsAltmetricConceptsStage IIIA melanomaHigh-volume centersRisk-adjusted survivalLow-volume centersImmunotherapy utilizationAdjuvant immunotherapyStage IIIATreatment of stage III melanomaAcademic centersMultivariable Cox proportional hazards regressionStage III melanomaNational Cancer DatabaseStage III diseaseFactors associated with receiptCox proportional hazards regressionCompare patient outcomesProportional hazards regressionIII melanomaImmunotherapy receiptReceiving immunotherapyIII diseaseImmunotherapy agentsOverall survivalSurvival benefitAdjuvant treatment
2023
Case report: Metastatic Merkel cell carcinoma presenting seven years after loco-regional disease resection of primary tumor with interval in-transit and nodal metastases
Rusheen J, Clune J, Ariyan S, Baumann R, Kluger H, Olino K, Weiss S. Case report: Metastatic Merkel cell carcinoma presenting seven years after loco-regional disease resection of primary tumor with interval in-transit and nodal metastases. Frontiers In Oncology 2023, 13: 1217816. PMID: 37476373, PMCID: PMC10354444, DOI: 10.3389/fonc.2023.1217816.Peer-Reviewed Case Reports and Technical NotesCitationsAltmetricConceptsMerkel cell carcinomaDuration of surveillanceLate recurrenceCell carcinomaMetastatic Merkel cell carcinomaPrimary Merkel cell carcinomaMetastases 15 monthsSuch late recurrencesPredictors of recurrenceNodal recurrenceDefinitive therapyFirst recurrenceDisease resectionNodal metastasisPhysical examinationRare tumorPrimary diagnosisPrimary tumorRisk factorsHigh riskNational guidelinesRecurrenceOptimal durationPatientsCarcinomaThe role of imaging and sentinel lymph node biopsy in patients with T3b-T4b melanoma with clinically negative disease
Papageorge M, Maina R, King A, Lee V, Baumann R, Pucar D, Ariyan S, Khan S, Weiss S, Clune J, Olino K. The role of imaging and sentinel lymph node biopsy in patients with T3b-T4b melanoma with clinically negative disease. Frontiers In Oncology 2023, 13: 1143354. PMID: 37223678, PMCID: PMC10200883, DOI: 10.3389/fonc.2023.1143354.Peer-Reviewed Original ResearchCitationsAltmetricConceptsPre-operative imagingCross-sectional imagingFree survivalLow-risk melanomaHigh-risk melanomaHigh-risk diseaseKaplan-Meier methodRecurrence-free survivalSentinel node biopsyWide local excisionManagement of patientsLog-rank testRole of imagingPropensity-score matchingIncidental cancerT4b diseaseMetastatic diseaseNodal diseaseNode biopsyPerioperative periodMedian ageNegative diseaseSentinel lymphLocal excisionNodular melanomaMalignant Melanoma in Older Adults: Different Patient or Different Disease?
Sasson D, Smetona J, Parsaei Y, Papageorge M, Ariyan S, Olino K, Clune J. Malignant Melanoma in Older Adults: Different Patient or Different Disease? Cureus 2023, 15: e34742. PMID: 36909026, PMCID: PMC9998075, DOI: 10.7759/cureus.34742.Peer-Reviewed Original ResearchCitationsAltmetricConceptsMelanoma-specific survivalRecurrence-free survivalOlder patientsT2 tumorsNodal positivityMetastatic progressionOlder adultsConclusion Older adultsLog-rank testingKaplan-Meier analysisT4 tumorsYounger patientsT1 tumorsBreslow thicknessClinical outcomesTumor characteristicsTumor thicknessSingle institutionClinical behaviorMalignant melanomaLower incidenceHigh incidencePatientsConsecutive sampleAge groupsPredictive accuracy of elevated mitotic rate on lymph node positivity and recurrence in thin melanomas
Ly C, Blaha O, Wei W, Galan A, Kluger H, Ariyan S, Olino K, Clune J. Predictive accuracy of elevated mitotic rate on lymph node positivity and recurrence in thin melanomas. Frontiers In Oncology 2023, 12: 1077226. PMID: 36686728, PMCID: PMC9853390, DOI: 10.3389/fonc.2022.1077226.Peer-Reviewed Original ResearchCitationsConceptsMelanoma-specific mortalityElevated mitotic rateLymph node positivityMitoses/Mitotic rateT2 tumorsNode positivityThin melanomasSentinel lymph node positivityImportant prognostic factorSingle academic centerPrimary cutaneous melanomaLow mitotic ratePositive SLNNon-ulcerated lesionsSLN biopsyT4 tumorsPatient demographicsPrognostic factorsSLN positivityRetrospective reviewTumor characteristicsBreslow thicknessCutaneous melanomaT category
2022
Author Correction: Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis
Farshidfar F, Rhrissorrakrai K, Levovitz C, Peng C, Knight J, Bacchiocchi A, Su J, Yin M, Sznol M, Ariyan S, Clune J, Olino K, Parida L, Nikolaus J, Zhang M, Zhao S, Wang Y, Huang G, Wan M, Li X, Cao J, Yan Q, Chen X, Newman AM, Halaban R. Author Correction: Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis. Nature Communications 2022, 13: 2704. PMID: 35538087, PMCID: PMC9090916, DOI: 10.1038/s41467-022-30446-w.Peer-Reviewed Original ResearchCitationsAltmetricIntegrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis
Farshidfar F, Rhrissorrakrai K, Levovitz C, Peng C, Knight J, Bacchiocchi A, Su J, Yin M, Sznol M, Ariyan S, Clune J, Olino K, Parida L, Nikolaus J, Zhang M, Zhao S, Wang Y, Huang G, Wan M, Li X, Cao J, Yan Q, Chen X, Newman AM, Halaban R. Integrative molecular and clinical profiling of acral melanoma links focal amplification of 22q11.21 to metastasis. Nature Communications 2022, 13: 898. PMID: 35197475, PMCID: PMC8866401, DOI: 10.1038/s41467-022-28566-4.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsAcral melanomaMelanoma subtypesClinical profilingCommon melanoma subtypeImmune checkpoint blockadeCheckpoint blockadeInferior survivalMelanoma cell linesKey molecular driversPoor prognosisTherapeutic targetAnchorage-independent growthImmunomodulatory genesNon-white individualsHotspot mutationsMolecular driversCandidate oncogeneMelanomaApoptotic cell deathLZTR1Focal amplificationTumor promoterCell linesMetastasisTumor suppressor
2017
Distinct dominant T-cell receptors with a tissue resident memory phenotype in individual melanoma metastases.
Dhodapkar K, Boddupalli C, Bar N, Kadaveru K, Krauthammer M, Pornputtapong N, Mai Z, Ariyan S, Narayan D, Kluger H, Deng Y, Verma R, Das R, Bacchiocchi A, Halaban R, Sznol M, Dhodapkar M. Distinct dominant T-cell receptors with a tissue resident memory phenotype in individual melanoma metastases. Journal Of Clinical Oncology 2017, 35: 3-3. DOI: 10.1200/jco.2017.35.7_suppl.3.Peer-Reviewed Original ResearchCitationsConceptsInhibitory immune checkpointsTissue-resident memory TT cellsIndividual metastasesMelanoma metastasesDominant T-cell receptorReduced T cell infiltrationTissue-resident memory phenotypeEffective anti-tumor immunityT-cell receptor sequencingTumor cellsExome sequencingResident memory phenotypeResident memory TT RM cellsAnti-tumor immunityT cell infiltrationCell receptor sequencingT cell subsetsAntibody-mediated blockadeT-cell contentVascular endothelial growth factorSingle-cell mass cytometryCell mass cytometryEndothelial growth factor
2016
Fibula Osteocutaneous Flap for Mandibular Reconstruction
Ariyan S. Fibula Osteocutaneous Flap for Mandibular Reconstruction. 2016, 369-372. DOI: 10.1007/978-3-319-40631-2_88.Peer-Reviewed Original ResearchConceptsPrevious radiation therapyHead neck cancerMicrovascular free flapsFibula osteocutaneous flapHead-neck areaSurgical treatmentBilateral resectionNeck cancerIntraoral bacteriaRadiation therapyOsteocutaneous flapFree flapNeck areaResectionIntraoral reconstructionDurable techniquePoor hygieneMandibular reconstructionSoft tissueMandibleTissue/Contralateral angleFlapBoneTherapyPectoralis Major Flap for Head and Neck Reconstruction
Ariyan S. Pectoralis Major Flap for Head and Neck Reconstruction. 2016, 365-368. DOI: 10.1007/978-3-319-40631-2_87.Peer-Reviewed Original ResearchConceptsMyocutaneous flapPectoralis major myocutaneous flapPrevious radiation therapyFree flap reconstructionPectoralis major flapMajor myocutaneous flapHead-neck areaFlap reconstructionMajor flapIntraoral bacteriaRadiation therapyNeck reconstructionNeck areaSurgical preparationPectoralis majorVascular anatomyPoor hygieneStage reconstructionFlapSurgical skillsReliable techniqueResectionTherapyCancer
Academic Achievements & Community Involvement
honor Albert Nelson Marquis Lifetime Achievement Award
National AwardMarquis Who's WhoDetails02/27/2017United Stateshonor MEDAL OF HONOR
National AwardNew York Medical CollegeDetails05/25/2016United Stateshonor Robert Goldwyn Lifetime Achievement Award
National AwardNew England Society of Plastic & Reconstructive SurgeonsDetails06/06/2015United Stateshonor Distinguished Fellow
National AwardAmerican Association of Plastic SurgeonsDetails03/23/2010United Stateshonor Presidential Citation
National AwardAmerican Head and Neck SocietyDetails04/15/2002United States
News
News
- October 23, 2023
Rare Case of Late-recurring Merkel Cell Carcinoma
- September 30, 2016
New Appointments
- April 27, 2016
Dr. Stephan Ariyan designated the Kanthak Professor in Plastic Surgery
- November 25, 2013
Yale Cancer Center 2013 Conclave Awards