Colibactin Exerts Androgen-dependent and -independent Effects on Prostate Cancer
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Alexander B, Bartfield N, Gupta V, Mercado B, Del Campo M, Herzon S. An oxidative photocyclization approach to the synthesis of Securiflustra securifrons alkaloids. Science 2024, 383: 849-854. PMID: 38386756, DOI: 10.1126/science.adl6163.Peer-Reviewed Original ResearchConceptsFunctional group manipulationsMicrocrystal electron diffractionOxidative photocyclizationAdvanced intermediateGroup manipulationsHeterocyclic residuesOxide ringSynthetic accessibilityElectron diffractionTarget identification studiesReactive alkenesModular assemblyCytotoxic alkaloidFlexible routeAlkenesIdentification studiesAlkaloidsPhotocycleDiffractionStructural complexityStructureRingIntermediateChemistrySynthesis