2021
YAP1 nuclear efflux and transcriptional reprograming follow membrane diminution upon VSV-G-induced cell fusion
Feliciano D, Ott CM, Espinosa-Medina I, Weigel AV, Benedetti L, Milano KM, Tang Z, Lee T, Kliman HJ, Guller SM, Lippincott-Schwartz J. YAP1 nuclear efflux and transcriptional reprograming follow membrane diminution upon VSV-G-induced cell fusion. Nature Communications 2021, 12: 4502. PMID: 34301937, PMCID: PMC8302681, DOI: 10.1038/s41467-021-24708-2.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAMP-Activated Protein KinasesAnimalsBiological TransportCell FusionCell LineCell Line, TumorCell MembraneCell NucleusCells, CulturedGiant CellsHEK293 CellsHumansMembrane GlycoproteinsMiceRNA-SeqSignal TransductionTranscription FactorsTranscription, GeneticViral Envelope ProteinsYAP-Signaling ProteinsConceptsCell cycle arrestCell fusionNew cellular statesPlasma membrane surface areaRNA-seq analysisCell fusion systemTranscriptional programsNutrient stressCellular statesTranscriptional changesNuclear effluxCytoplasmic glucoseExtrinsic cuesUndifferentiated cellsGlucose transporterFused cellsMechanistic insightsMembrane surface areaNew functionsEndocytosisYAP1 inhibitionEnergetic stateSyncytiaCellsVSV
2004
A Novel Immortalized Human Endometrial Stromal Cell Line with Normal Progestational Response
Krikun G, Mor G, Alvero A, Guller S, Schatz F, Sapi E, Rahman M, Caze R, Qumsiyeh M, Lockwood CJ. A Novel Immortalized Human Endometrial Stromal Cell Line with Normal Progestational Response. Endocrinology 2004, 145: 2291-2296. PMID: 14726435, DOI: 10.1210/en.2003-1606.Peer-Reviewed Original ResearchMeSH KeywordsCell Line, TransformedDeciduaEndometriumEstradiolFas Ligand ProteinFas ReceptorFemaleFibronectinsGene ExpressionHot TemperatureHumansInsulin-Like Growth Factor Binding Protein 1KaryotypingMedroxyprogesterone AcetateMembrane GlycoproteinsPlasminogen Activator Inhibitor 1ProgestinsProlactinStromal CellsTelomeraseThromboplastinConceptsHuman endometrial stromal cellsImmortalized human endometrial stromal cell lineHuman endometrial stromal cell lineCultured human endometrial stromal cellsEndometrial stromal cell linePrimary human endometrial stromal cellsPlasminogen activator inhibitor-1Endometrial stromal cellsExpression of IGFFas/Fas ligandActivator inhibitor-1Cell linesProgestational responseParent cellsOvarian steroidsMedroxyprogesterone acetateDecidualization responseAbnormal karyotypeStromal cell lineTissue factorNew cell lineStromal cellsFas ligandInhibitor-1Process of immortalizationFirst trimester trophoblast cells secrete Fas ligand which induces immune cell apoptosis
Abrahams VM, Straszewski-Chavez S, Guller S, Mor G. First trimester trophoblast cells secrete Fas ligand which induces immune cell apoptosis. Molecular Human Reproduction 2004, 10: 55-63. PMID: 14665707, DOI: 10.1093/molehr/gah006.Peer-Reviewed Original ResearchMeSH KeywordsApoptosisFas Ligand ProteinHumansMembrane GlycoproteinsPlacentaPregnancy Trimester, FirstTrophoblastsConceptsFirst trimester trophoblast cellsImmune privilegeTrophoblast cellsFas/Fas ligand (FasL) apoptotic pathwayMaternal immune recognitionMaternal immune systemImmune cell apoptosisSecretion of FasLT cell deathPaternal alloantigensAllograft rejectionNormal pregnancyPeripheral toleranceImmune recognitionImmune systemRelease of microvesiclesFas ligandCell apoptosisVivo studiesFasLMembrane-associated expressionTrophoblastIntracellular FasLApoptotic pathwayDeath