2014
Evolving Character of Chronic Central Nervous System HIV Infection
Price RW, Spudich SS, Peterson J, Joseph S, Fuchs D, Zetterberg H, Gisslén M, Swanstrom R. Evolving Character of Chronic Central Nervous System HIV Infection. Seminars In Neurology 2014, 34: 007-013. PMID: 24715483, PMCID: PMC4120280, DOI: 10.1055/s-0034-1372337.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyCentral nervous systemHuman immunodeficiency virus type 1 (HIV-1) infectionCentral nervous system HIV infectionSystemic infectionVirus type 1 infectionCombination antiretroviral therapyType 1 infectionResource-poor settingsUntreated courseCNS infectionsHIV infectionClinical presentationMotor dysfunctionCNS injuryInflammatory responseNervous systemViral pathogenesisInfectionCharacteristic cognitiveDysfunctionBroad prevalenceHADMarked declineSevere consequences
2012
The cerebrospinal fluid proteome in HIV infection: change associated with disease severity
Angel TE, Jacobs JM, Spudich SS, Gritsenko MA, Fuchs D, Liegler T, Zetterberg H, Camp DG, Price RW, Smith RD. The cerebrospinal fluid proteome in HIV infection: change associated with disease severity. Clinical Proteomics 2012, 9: 3. PMID: 22433316, PMCID: PMC3353874, DOI: 10.1186/1559-0275-9-3.Peer-Reviewed Original ResearchCNS HIV infectionHIV infectionCerebrospinal fluidChronic asymptomatic infectionSystemic HIV infectionNervous system infectionAmyloid precursor proteinCSF proteomic analysisCerebrospinal fluid proteomeCSF neopterinAntiretroviral therapyDifferent time pointsSystem infectionNeural injuryImmune activationMotor dysfunctionAsymptomatic infectionClinical spectrumCSF biomarkersCSF analysisDisease progressionCSF samplesNeuronal plasticityDisease severityInfection