1999
Nucleotide Analog Interference Mapping
Ryder S, Strobel S. Nucleotide Analog Interference Mapping. Methods 1999, 18: 38-50. PMID: 10208815, DOI: 10.1006/meth.1999.0755.Peer-Reviewed Original ResearchMeSH KeywordsAdenosineGuanosineModels, ChemicalModels, GeneticNucleotide MappingPhosphorusPyrimidinesRNAThionucleotidesTranscription, GeneticConceptsFunctional groupsActive moleculesGroup substitutionNucleotide analog interference mappingIncorporation propertiesIndividual analoguesMoleculesSeries 5AnaloguesSubstitution experimentsGel electrophoresisInterference mappingUnique biochemical signatureSubstitutionSynthesisNucleoside analog triphosphatesActivity assaysBiochemical informationReactionAnalog substitutionsAssayable functionChemogenetic approachRNA structureNucleotide analoguesIodineA hydrogen-bonding triad stabilizes the chemical transition state of a group I ribozyme
Strobel S, Ortoleva-Donnelly L. A hydrogen-bonding triad stabilizes the chemical transition state of a group I ribozyme. Cell Chemical Biology 1999, 6: 153-165. PMID: 10074469, DOI: 10.1016/s1074-5521(99)89007-3.Peer-Reviewed Original Research
1998
Ribozyme chemogenetics
Strobel S. Ribozyme chemogenetics. Biopolymers 1998, 48: 65-81. PMID: 9846125, DOI: 10.1002/(sici)1097-0282(1998)48:1<65::aid-bip7>3.0.co;2-d.Peer-Reviewed Original ResearchMeSH KeywordsModels, MolecularMutagenesis, Site-DirectedNucleic Acid ConformationNucleotide MappingRNA, CatalyticConceptsHelix-helix packing interactionsDNA-protein interactionsLarge catalytic RNAsSingle-site substitutionsRibozyme catalytic coreTetrahymena group ICatalytic coreTertiary hydrogen bondsCatalytic RNAGenetic revertantsReceptor motifRibozyme functionPacking interactionsChemogenetic approachChemical correlatesReview ISuppressorGenetic analogyRevertantsTriple helixChemical basisNucleotide analoguesModification experimentsMutagenesisRNA