2023
Long-term safety and maintenance of response with esketamine nasal spray in participants with treatment-resistant depression: interim results of the SUSTAIN-3 study
Zaki N, Chen L, Lane R, Doherty T, Drevets W, Morrison R, Sanacora G, Wilkinson S, Popova V, Fu D. Long-term safety and maintenance of response with esketamine nasal spray in participants with treatment-resistant depression: interim results of the SUSTAIN-3 study. Neuropsychopharmacology 2023, 48: 1225-1233. PMID: 37173512, PMCID: PMC10267177, DOI: 10.1038/s41386-023-01577-5.Peer-Reviewed Original ResearchConceptsTreatment-resistant depressionEsketamine treatmentMontgomery-Åsberg Depression Rating Scale (MADRS) total scoreCommon treatment-emergent adverse eventsLong-term extension studyTreatment-emergent adverse eventsEsketamine nasal sprayMean cumulative durationLong-term tolerabilityNew safety signalsHealth-related qualityMaintenance of responseLong-term treatmentMajor depressive disorderLong-term safetyPhase 3Scale total scoreMaintenance phaseOral antidepressantsData cutoffAdverse eventsMaintenance treatmentSustained efficacyEligible participantsDepression ratings
2019
DEPRESSIVE DISORDERS IN OLDER ADULTS ASSOCIATIONS OF ADVERSE CHILDHOOD EXPERIENCES WITH DSM-5 DEPRESSIVE DISORDERS AND SUICIDE ATTEMPT IN OLDER ADULTS
Rhee T, Barry L, Kuchel G, Steffens D, Wilkinson S. DEPRESSIVE DISORDERS IN OLDER ADULTS ASSOCIATIONS OF ADVERSE CHILDHOOD EXPERIENCES WITH DSM-5 DEPRESSIVE DISORDERS AND SUICIDE ATTEMPT IN OLDER ADULTS. Innovation In Aging 2019, 3: s571-s572. PMCID: PMC6841627, DOI: 10.1093/geroni/igz038.2117.Peer-Reviewed Original ResearchAdverse childhood experiencesMajor depressive disorderDepressive disorderLifetime suicide attemptsSuicide attemptsOlder adultsHigher oddsForms of ACEsMultivariable-adjusted logistic regression analysesPast-year major depressive disorderAssociation of ACEsDSM-5 depressive disordersPrevalence of ACEsImportant public health goalRelated Conditions Wave IIIUS older adultsLogistic regression analysisNational Epidemiological SurveyPublic health goalsDSM-5 criteriaChildhood experiencesLong-term benefitsNational prevalenceLong-term effectsMood disorders
2018
Identifying Recipients of Electroconvulsive Therapy: Data From Privately Insured Americans
Wilkinson ST, Agbese E, Leslie DL, Rosenheck RA. Identifying Recipients of Electroconvulsive Therapy: Data From Privately Insured Americans. Psychiatric Services 2018, 69: 542-548. PMID: 29385954, PMCID: PMC6248332, DOI: 10.1176/appi.ps.201700364.Peer-Reviewed Original ResearchConceptsElectroconvulsive therapyMood disordersClinical characteristicsECT useUse of ECTCharacteristics of patientsProportion of patientsComorbid psychiatric disordersMajor depressive disorderNumber of prescriptionsSubstance use disordersOutpatient psychotherapy visitsECT patientsECT utilization rateMarketScan databasePsychotherapy visitsPsychotropic medicationsDepressive disorderPsychiatric disordersService useUse disordersPatientsECT utilizationBipolar disorderCommercial insurance
2017
Hippocampal Volume Changes Following Electroconvulsive Therapy: A Systematic Review and Meta-analysis
Wilkinson ST, Sanacora G, Bloch MH. Hippocampal Volume Changes Following Electroconvulsive Therapy: A Systematic Review and Meta-analysis. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2017, 2: 327-335. PMID: 28989984, PMCID: PMC5627663, DOI: 10.1016/j.bpsc.2017.01.011.Peer-Reviewed Original ResearchMajor depressive disorderElectroconvulsive therapyTotal hippocampal volumeHippocampal volumeStandardized mean differenceConsistent morphological findingsHippocampal volume increasesCognitive side effectsPre-treatment valuesHippocampal volume changesRandom-effects modelMechanism of actionClinical improvementPrimary outcomeECT treatmentDepressive disorderEffective therapyNeuroplastic processesECT studiesSide effectsAnimal modelsDepression symptomsMeta-AnalysisSystematic reviewMorphological findings