2019
The effects of MicroRNA deregulation on pre-RNA processing network in multiple myeloma
Adamia S, Abiatari I, Amin S, Fulciniti M, Minvielle S, Li C, Moreau P, Avet-Loiseau H, Munshi N, Anderson K. The effects of MicroRNA deregulation on pre-RNA processing network in multiple myeloma. Leukemia 2019, 34: 167-179. PMID: 31182781, PMCID: PMC6901818, DOI: 10.1038/s41375-019-0498-5.Peer-Reviewed Original ResearchConceptsMultiple myelomaPlasma cellsOvert multiple myelomaPatient outcomesMM cellsMM pathogenesisLet-7fMicroRNA deregulationRegulation of microRNAsCD138Certain miRsMyelomaMiRDependent gene expressionDeregulated expressionMiR-mediated regulationSignificant numberEpigenetic lesionsTarget genesMM genomesExpressionGene expressionEarly stagesCellsPatients
2016
miR-182-5p Induced by STAT3 Activation Promotes Glioma Tumorigenesis
Xue J, Zhou A, Wu Y, Morris S, Lin K, Amin S, Verhaak R, Fuller G, Xie K, Heimberger A, Huang S. miR-182-5p Induced by STAT3 Activation Promotes Glioma Tumorigenesis. Cancer Research 2016, 76: 4293-4304. PMID: 27246830, PMCID: PMC5033679, DOI: 10.1158/0008-5472.can-15-3073.Peer-Reviewed Original ResearchConceptsProtocadherin-8Glioma tumorigenesisProtein-coding genesMiRNA gene transcriptionCandidate target genesExpression of STAT3Gene transcriptionBioinformatics analysisTarget genesSTAT3/miRSTAT3 knockdownPCDH8 expressionSTAT3 inhibitorAberrant activationGlioblastoma tissuesSTAT3Expression levelsInvasive capacityTranscriptionTumorigenesisGlioma progressionGenesCritical roleKnockdownP-STAT3
2014
MicroRNA expression patterns in medullary and extramedullary plasmacytoma
Lin J, Mahindra A, Santo L, Amin S, Sohani A, Raje N. MicroRNA expression patterns in medullary and extramedullary plasmacytoma. Blood Cancer Journal 2014, 4: e223-e223. PMID: 24972152, PMCID: PMC4080212, DOI: 10.1038/bcj.2014.41.Peer-Reviewed Original Research
2012
Investigational agent MLN9708/2238 targets tumor-suppressor miR33b in MM cells
Tian Z, Zhao J, Tai Y, Amin S, Hu Y, Berger A, Richardson P, Chauhan D, Anderson K. Investigational agent MLN9708/2238 targets tumor-suppressor miR33b in MM cells. Blood 2012, 120: 3958-3967. PMID: 22983447, PMCID: PMC3496955, DOI: 10.1182/blood-2012-01-401794.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntineoplastic AgentsBoron CompoundsCell DeathCell Line, TumorCell MovementCell SurvivalCluster AnalysisDrug Resistance, NeoplasmGene Expression ProfilingGene Expression Regulation, NeoplasticGenes, Tumor SuppressorGlycineHumansImidazolesMiceMicroRNAsMultiple MyelomaProto-Oncogene Proteins c-pim-1PyridazinesSignal TransductionXenograft Model Antitumor AssaysConceptsMultiple myelomaMM cellsPim-1Tumor suppressor geneTranscriptional regulationPim-1 overexpressionBiochemical inhibitorsApoptotic signalingRole of miRTumor suppressorMiR33bMM cell viabilityCell deathPatient MM cellsMM xenograft modelNovel therapeutic strategiesLuciferase activityColony formationOverexpressionMiR profilingTumor pathogenesisInvestigational agentsCritical roleRegulationCell viabilityIntegrative analysis of gene and miRNA expression profiles with transcription factor–miRNA feed-forward loops identifies regulators in human cancers
Yan Z, Shah P, Amin S, Samur M, Huang N, Wang X, Misra V, Ji H, Gabuzda D, Li C. Integrative analysis of gene and miRNA expression profiles with transcription factor–miRNA feed-forward loops identifies regulators in human cancers. Nucleic Acids Research 2012, 40: e135-e135. PMID: 22645320, PMCID: PMC3458521, DOI: 10.1093/nar/gks395.Peer-Reviewed Original ResearchConceptsFeed-forward loopTranscription factorsMiRNA expression profilesExpression profilesNovel feed-forward loopCancer-related transcription factorsExpression dataTF target genesMiRNA-mRNA interactionsCommon target genesMiR-15/miRMiRNA expression dataMiRNA partnersTranscriptome changesTarget genesDifferential genesIntegrative analysisMultiple cancer typesGenesMiRNA expressionHuman cancersLiterature validationBiological conditionsMiRNAsRegulator