2013
Transcription factor-pathway coexpression analysis reveals cooperation between SP1 and ESR1 on dysregulating cell cycle arrest in non-hyperdiploid multiple myeloma
Wang X, Yan Z, Fulciniti M, Li Y, Gkotzamanidou M, Amin S, Shah P, Zhang Y, Munshi N, Li C. Transcription factor-pathway coexpression analysis reveals cooperation between SP1 and ESR1 on dysregulating cell cycle arrest in non-hyperdiploid multiple myeloma. Leukemia 2013, 28: 894-903. PMID: 23925045, PMCID: PMC4155324, DOI: 10.1038/leu.2013.233.Peer-Reviewed Original ResearchConceptsCell cycle arrestCycle arrestCoexpression analysisCell cycle arrest genesHyperdiploid MMCell cycle arrest pathwaysNon-hyperdiploid multiple myelomaDistinct chromosomal alterationsMyeloma subtypeMultiple myelomaTranscription factorsArrest pathwaysSp1Low coexpressionProper regulationHuman cancersDifferent survival outcomesChromosomal alterationsPlasma B cellsCoexpressionCell linesNovel hypothesisSurvival outcomesMyeloma proliferationClinical utility
2012
Integrative analysis of gene and miRNA expression profiles with transcription factor–miRNA feed-forward loops identifies regulators in human cancers
Yan Z, Shah P, Amin S, Samur M, Huang N, Wang X, Misra V, Ji H, Gabuzda D, Li C. Integrative analysis of gene and miRNA expression profiles with transcription factor–miRNA feed-forward loops identifies regulators in human cancers. Nucleic Acids Research 2012, 40: e135-e135. PMID: 22645320, PMCID: PMC3458521, DOI: 10.1093/nar/gks395.Peer-Reviewed Original ResearchMeSH KeywordsFeedback, PhysiologicalGene Expression Regulation, NeoplasticGene Regulatory NetworksHumansMicroRNAsNeoplasmsTranscription FactorsTranscriptomeConceptsFeed-forward loopTranscription factorsMiRNA expression profilesExpression profilesNovel feed-forward loopCancer-related transcription factorsExpression dataTF target genesMiRNA-mRNA interactionsCommon target genesMiR-15/miRMiRNA expression dataMiRNA partnersTranscriptome changesTarget genesDifferential genesIntegrative analysisMultiple cancer typesGenesMiRNA expressionHuman cancersLiterature validationBiological conditionsMiRNAsRegulator