2016
miR-182-5p Induced by STAT3 Activation Promotes Glioma Tumorigenesis
Xue J, Zhou A, Wu Y, Morris S, Lin K, Amin S, Verhaak R, Fuller G, Xie K, Heimberger A, Huang S. miR-182-5p Induced by STAT3 Activation Promotes Glioma Tumorigenesis. Cancer Research 2016, 76: 4293-4304. PMID: 27246830, PMCID: PMC5033679, DOI: 10.1158/0008-5472.can-15-3073.Peer-Reviewed Original ResearchConceptsProtocadherin-8Glioma tumorigenesisProtein-coding genesMiRNA gene transcriptionCandidate target genesExpression of STAT3Gene transcriptionBioinformatics analysisTarget genesSTAT3/miRSTAT3 knockdownPCDH8 expressionSTAT3 inhibitorAberrant activationGlioblastoma tissuesSTAT3Expression levelsInvasive capacityTranscriptionTumorigenesisGlioma progressionGenesCritical roleKnockdownP-STAT3
2013
Bone Marrow Microenvironment Affects The Pathogenesis Of Multiple Myeloma Through Downregulation Of Alternative Splicing Factor Fox2 In Myeloma Cells
Song W, Zhang C, Hu Y, Gkotzamanidou M, Shah P, Shan W, Yang G, Amin S, Tai Y, Li Y, Sperling A, Rashid N, Magrangeas F, Minvielle S, Avet-Loiseau H, Anderson K, Li C, Munshi N. Bone Marrow Microenvironment Affects The Pathogenesis Of Multiple Myeloma Through Downregulation Of Alternative Splicing Factor Fox2 In Myeloma Cells. Blood 2013, 122: 3085. DOI: 10.1182/blood.v122.21.3085.3085.Peer-Reviewed Original ResearchAlternate splicingActin polymerizationCell linesRPMI8226 cell lineMM cell linesAlternative splicing regulatorsImportant splicing factorsAlternative splicing eventsGeneChip Human Exon 1.0 ST ArrayHuman Exon 1.0 ST ArrayPredominant nuclear localizationRNA-seq dataExpression levelsIGF-1 stimulationPost-translational changesGene expression levelsSplicing regulatorsGene functionStromal cell interactionsRNA splicingSplicing eventsSplicing factorsAlternative splicingRNA-seqMolecular role