1995
Progression to AIDS in the absence of a gene for vpr or vpx
Gibbs J, Lackner A, Lang S, Simon M, Sehgal P, Daniel M, Desrosiers R. Progression to AIDS in the absence of a gene for vpr or vpx. Journal Of Virology 1995, 69: 2378-2383. PMID: 7884883, PMCID: PMC188910, DOI: 10.1128/jvi.69.4.2378-2383.1995.Peer-Reviewed Original ResearchConceptsLow virus burdenSimian immunodeficiency virusVirus burdenRhesus monkeysLymphocyte concentrationsPlasma antigenemiaHigh virus burdenLymph node morphologyImmunodeficiency virusDisease progressionSIVmac replicationPrimate lentivirusesVirus replicationWild-type virusNode morphologyAIDSVpx geneTerminal stageProgressionAntigenemiaCD4VpxMonkeysEarly spikeBurden
1993
Importance of vpr for infection of rhesus monkeys with simian immunodeficiency virus
Lang S, Weeger M, Stahl-Hennig C, Coulibaly C, Hunsmann G, Müller J, Müller-Hermelink H, Fuchs D, Wachter H, Daniel M. Importance of vpr for infection of rhesus monkeys with simian immunodeficiency virus. Journal Of Virology 1993, 67: 902-912. PMID: 8380472, PMCID: PMC237444, DOI: 10.1128/jvi.67.2.902-912.1993.Peer-Reviewed Original ResearchConceptsVpr variantsTAA stop codonVpr geneATG start codonSite-specific mutagenesisVpr mutant virusSignificant selective pressureImportance of VprStart codonSelective pressureVpr mutantsStop codonGenesPathogenic molecular cloneMolecular cloneCell linesVprTest animalsCEMx174 cell lineCodonNef geneSimilar kineticsVirus replicationReversionStop signal