Die Expression der ζ-Kette des T-Zell-Rezeptors als Prognosemarker bei Kopf-Hals-Karzinomen
Müller D, Lang S, Roskrow M, Wollenberg B. Die Expression der ζ-Kette des T-Zell-Rezeptors als Prognosemarker bei Kopf-Hals-Karzinomen. Laryngo-Rhino-Otologie 2002, 81: 516-520. PMID: 12173063, DOI: 10.1055/s-2002-33289.Peer-Reviewed Original ResearchConceptsTumor-infiltrating lymphocytesZeta chain expressionPeripheral blood lymphocytesT cell receptorTumor stageZeta chainCorrelated to clinical dataMechanisms of immune suppressionT cell receptor zeta chainSystemic immune defectsAnti-tumor responsesEarly tumor stageHigher tumor stageSquamous cell carcinomaHead and neckT cell activationFlow cytometric analysisSystemic immunomodulationImmune defectsInfiltrating lymphocytesClinical aggressivenessCell carcinomaImmune suppressionBlood lymphocytesSCCHN