2024
A pilot study to evaluate the effect of CT1812 treatment on synaptic density and other biomarkers in Alzheimer’s disease
van Dyck C, Mecca A, O’Dell R, Bartlett H, Diepenbrock N, Huang Y, Hamby M, Grundman M, Catalano S, Caggiano A, Carson R. A pilot study to evaluate the effect of CT1812 treatment on synaptic density and other biomarkers in Alzheimer’s disease. Alzheimer's Research & Therapy 2024, 16: 20. PMID: 38273408, PMCID: PMC10809445, DOI: 10.1186/s13195-024-01382-2.Peer-Reviewed Original ResearchConceptsMild to moderate dementiaPositron emission tomographyAlzheimer's diseaseVolumetric MRIModerate dementiaClinical rating scalesSynaptic vesicle glycoprotein 2ACerebrospinal fluidMouse model of ADPharmacodynamic effectsPlacebo-controlled phase 1 clinical trialBiomarkers of AD pathologyClinical trialsCognitive measuresNominally significant differencesPhase 1 clinical trialModel of ADHippocampal cortexPhase 1/2 studyRating ScaleParallel-group trialSynaptic densityTrial registrationThe clinical trialPlacebo-controlledSigma-2 receptor ligands
2015
Reelin Prevents Apical Neurite Retraction during Terminal Translocation and Dendrite Initiation
O'Dell RS, Cameron DA, Zipfel WR, Olson EC. Reelin Prevents Apical Neurite Retraction during Terminal Translocation and Dendrite Initiation. Journal Of Neuroscience 2015, 35: 10659-10674. PMID: 26224852, PMCID: PMC4518046, DOI: 10.1523/jneurosci.1629-15.2015.Peer-Reviewed Original ResearchConceptsApical dendritesCortical laminationGlycoprotein ReelinMigration arrestPrimary neuritesMarginal zoneNormal target areaWild-type neuronsSubset of neuronsReeler cortexReeler neuronsDendritic arborsDendritic outgrowthReelin functionMouse cortexReelin proteinNeuronal migrationNeuronsLeading processCortexReelinMin periodNeurite retractionNeuritesTerminal phase
2013
Ex utero electroporation and whole hemisphere explants: a simple experimental method for studies of early cortical development.
Nichols AJ, O'Dell RS, Powrozek TA, Olson EC. Ex utero electroporation and whole hemisphere explants: a simple experimental method for studies of early cortical development. Journal Of Visualized Experiments 2013 PMID: 23609059, PMCID: PMC3643163, DOI: 10.3791/50271.Peer-Reviewed Original ResearchConceptsEarly cortical developmentCortical developmentExplant modelUtero electroporationNon-neuronal elementsPreplate splittingCortical slicesPharmacological interventionsNeuronal proliferationMedial cortexCellular laminationSurvival surgeryBlood vesselsExplant systemNeuronal differentiationPrecursor cellsSlice explantsNeuronsLive imaging approachesOrganotypic environmentImaging approachExtracellular matrixSurgeryMeningesCortex
2012
Layer 6 cortical neurons require Reelin-Dab1 signaling for cellular orientation, Golgi deployment, and directed neurite growth into the marginal zone
O’Dell R, Ustine CJ, Cameron DA, Lawless SM, Williams RM, Zipfel WR, Olson EC. Layer 6 cortical neurons require Reelin-Dab1 signaling for cellular orientation, Golgi deployment, and directed neurite growth into the marginal zone. Neural Development 2012, 7: 25. PMID: 22770513, PMCID: PMC3466444, DOI: 10.1186/1749-8104-7-25.Peer-Reviewed Original ResearchConceptsEarly cortical developmentMutant cortexCortical neuronsCortical developmentPial surfaceMarginal zoneApical neuritesL6 neuronsRecombinant ReelinNeocortical neuronsNeuronal somataReelin-Dab1Arbor lengthArbor sizeExplant modelVentricular zonePioneer neuronsMutant neuronsReelinNeuronsConclusionsThese findingsMore primary processesNeuronal orientationCortexNeurite growth