2022
Impact of delivery rate on the acute response to intravenous nicotine: A human laboratory study with implications for regulatory science
De Aquino JP, MacLean RR, Gueorguieva R, DeVito EE, Eid T, Sofuoglu M. Impact of delivery rate on the acute response to intravenous nicotine: A human laboratory study with implications for regulatory science. Addiction Biology 2022, 27: e13161. PMID: 35229960, PMCID: PMC8903077, DOI: 10.1111/adb.13161.Peer-Reviewed Original ResearchConceptsAbuse potentialPositive subjective drug effectsSubjective drug effectsHuman laboratory studiesPositive subjective effectsAttention functionSmoking urgesOvernight abstinencePotential therapeutic effectsEffects of nicotineHeart rate increaseDelivery rateDependent smokersExperimental sessionsSubjective effectsNicotine dependenceIntravenous nicotineBlood pressureSaline infusionAcute effectsTherapeutic effectHeart rateDrug effectsAcute responseCrossover design
2021
Threshold dose for intravenous nicotine self-administration in young adult non-dependent smokers
MacLean RR, DeVito EE, Eid T, Parida S, Gueorguieva R, Sofuoglu M. Threshold dose for intravenous nicotine self-administration in young adult non-dependent smokers. Psychopharmacology 2021, 238: 2083-2090. PMID: 33796907, PMCID: PMC8715498, DOI: 10.1007/s00213-021-05833-8.Peer-Reviewed Original ResearchConceptsDose of nicotineNicotine reinforcementHigh doseSubjective effectsHuman laboratory studiesYoung adult smokersNicotine self-administration modelNon-dependent smokersOvernight nicotine abstinenceEffects modelSelf-administration modelSelf-administration procedureNicotine doseAdult smokersMethodsYoung adultsObjectivesThe current studyNicotine abstinenceNicotine addictionHigh dosesLow dosesPlaceboThreshold doseReinforcement thresholdTobacco productsDoseThe feasibility of an in‐scanner smoking lapse paradigm to examine the neural correlates of lapses
Lydon‐Staley D, MacLean RR, Falk EB, Bassett DS, Wilson SJ. The feasibility of an in‐scanner smoking lapse paradigm to examine the neural correlates of lapses. Addiction Biology 2021, 26: e13001. PMID: 33508880, PMCID: PMC8225575, DOI: 10.1111/adb.13001.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingFunctional brain systemsCognitive controlBrain systemsDefault mode systemLapse behaviorSmoking cessation attemptFrontoparietal systemNeural correlatesMonetary rewardsBehavioral paradigmsNeural activityInitial evidenceScanning sessionSmoking abstinenceCessation attemptsDaily smokersTime-varying changesSingle scanning sessionQuitting smokingBehavioral modelMagnetic resonance imagingAbstinenceParticipantsParadigm
2020
Complex Persistent Opioid Dependence with Long-term Opioids: a Gray Area That Needs Definition, Better Understanding, Treatment Guidance, and Policy Changes
Manhapra A, Sullivan MD, Ballantyne JC, MacLean RR, Becker WC. Complex Persistent Opioid Dependence with Long-term Opioids: a Gray Area That Needs Definition, Better Understanding, Treatment Guidance, and Policy Changes. Journal Of General Internal Medicine 2020, 35: 964-971. PMID: 33159241, PMCID: PMC7728942, DOI: 10.1007/s11606-020-06251-w.Peer-Reviewed Original ResearchConceptsLong-term opioid therapyOpioid taperingOpioid dependenceChronic pain refractoryUtilization of buprenorphineLong-term opioidsSevere chronic painOpioid use disorderMultitude of treatmentsLimited supportive evidenceOpioid therapyPain refractoryBuprenorphine treatmentChronic painClinical instabilityRecent guidelinesClinical definitionUS adultsUse disordersDiagnosis/Treatment guidancePainComplicationsTreatmentSupportive evidenceNaturalistic measurement of dual cue attentional bias in moderate to heavy-drinking smokers: A preliminary investigation
MacLean RR, Sofuoglu M, Waters AJ. Naturalistic measurement of dual cue attentional bias in moderate to heavy-drinking smokers: A preliminary investigation. Drug And Alcohol Dependence 2020, 209: 107892. PMID: 32058247, DOI: 10.1016/j.drugalcdep.2020.107892.Peer-Reviewed Original ResearchConceptsAlcohol attentional biasAttentional biasAlcohol cuesAmbulatory assessmentPossible cognitive mechanismsTask four timesHeavy drinking smokersCognitive mechanismsCue typesDrug cuesPreferential attentionNaturalistic measurementsCuesAlcohol useDaily smokersSubject associationsLarge sampleDaily lifeBiasFurther researchFirst studyPreliminary investigationCravingHeavy amountsCigarettes
2018
Attentional bias in opioid users: A systematic review and meta-analysis
MacLean RR, Sofuoglu M, Brede E, Robinson C, Waters AJ. Attentional bias in opioid users: A systematic review and meta-analysis. Drug And Alcohol Dependence 2018, 191: 270-278. PMID: 30157467, DOI: 10.1016/j.drugalcdep.2018.07.012.Peer-Reviewed Original ResearchConceptsAttentional biasNeutral stimuliBehavioral treatmentRobust attentional biasAdjunctive behavioral treatmentsOpioid use disorderAttention biasOpioid cuesSalient stimuliEligible peer-reviewed studiesStimuliUse disordersOpioid usersCurrent studySystematic reviewPeer-reviewed studiesNational public health emergencyBiasComprehensive literature searchTreatment outcomesPublic health emergencyOpioid useActive responseCuesPrimary treatment