2020
Relationship Between Depressive Symptoms and Health Status in Peripheral Artery Disease: Role of Sex Differences
Jelani Q, Mena‐Hurtado C, Burg M, Soufer R, Gosch K, Jones PG, Spertus JA, Safdar B, Smolderen KG. Relationship Between Depressive Symptoms and Health Status in Peripheral Artery Disease: Role of Sex Differences. Journal Of The American Heart Association 2020, 9: e014583. PMID: 32781883, PMCID: PMC7660812, DOI: 10.1161/jaha.119.014583.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseDepressive symptomsHealth statusArtery diseaseEQ-5D visual analog scale scoresEQ-5D visual analog scaleVisual analog scale scoreGeneric health statusPeripheral Artery QuestionnaireVascular specialty clinicsAnalog scale scoreHealth status scoresPatient Health QuestionnaireSevere depressive symptomsVisual analog scaleHealth status outcomesWorse health statusAdjusted general linear modelSex differencesPORTRAIT registryPAD diagnosisPAD symptomsAnalog scaleConclusions WomenMean age
2019
Effect of β-blockers on triggering of symptomatic atrial fibrillation by anger or stress
Lampert R, Burg MM, Jamner LD, Dziura J, Brandt C, Li F, Donovan T, Soufer R. Effect of β-blockers on triggering of symptomatic atrial fibrillation by anger or stress. Heart Rhythm 2019, 16: 1167-1173. PMID: 31171436, PMCID: PMC6759206, DOI: 10.1016/j.hrthm.2019.03.004.Peer-Reviewed Original ResearchConceptsAtrial fibrillationΒ-blockersAF episodesHistory of AFControl periodSymptomatic AF episodesSymptomatic atrial fibrillationΒ-blocker useExclusion of patientsPersistent atrial fibrillationHolter monitoringAF symptomsPatientsPatient exposureCase periodFibrillationMood statesEpisodesEvent monitorDeleterious physiological responsesExposurePhysiological responsesDiary dataSotalol
2016
Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1&bgr; Production
Ceneri N, Zhao L, Young BD, Healy A, Coskun S, Vasavada H, Yarovinsky TO, Ike K, Pardi R, Qin L, Qin L, Tellides G, Hirschi K, Meadows J, Soufer R, Chun HJ, Sadeghi M, Bender JR, Morrison AR. Rac2 Modulates Atherosclerotic Calcification by Regulating Macrophage Interleukin-1&bgr; Production. Arteriosclerosis Thrombosis And Vascular Biology 2016, 37: 328-340. PMID: 27834690, PMCID: PMC5269510, DOI: 10.1161/atvbaha.116.308507.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAortaAortic DiseasesApolipoproteins EAtherosclerosisCells, CulturedCoronary Artery DiseaseCoronary VesselsFemaleGenetic Predisposition to DiseaseHumansInflammation MediatorsInterleukin 1 Receptor Antagonist ProteinInterleukin-1betaMacrophagesMaleMice, Inbred C57BLMice, KnockoutMuscle, Smooth, VascularMyocytes, Smooth MuscleNeuropeptidesPhenotypePlaque, AtheroscleroticPrognosisRac GTP-Binding ProteinsRac1 GTP-Binding ProteinSignal TransductionTransfectionUp-RegulationVascular CalcificationConceptsCoronary calcium burdenIL-1β expressionCalcium burdenSerum IL-1β levelsElevated IL-1βIL-1β levelsCoronary artery diseaseInterleukin-1β expressionCalcified coronary arteryCardiovascular deathCardiovascular eventsArtery diseaseIndependent predictorsClinical outcomesVascular calcificationCoronary arteryIL-1βPlaque calciumAtherosclerotic calcificationExperimental atherogenesisInflammatory regulatorsMacrophage interleukinAtherosclerotic plaquesTherapeutic targetProgressive calcification
2014
Confluence of Depression and Acute Psychological Stress Among Patients With Stable Coronary Heart Disease: Effects on Myocardial Perfusion
Burg MM, Meadows J, Shimbo D, Davidson KW, Schwartz JE, Soufer R. Confluence of Depression and Acute Psychological Stress Among Patients With Stable Coronary Heart Disease: Effects on Myocardial Perfusion. Journal Of The American Heart Association 2014, 3: e000898. PMID: 25359402, PMCID: PMC4338683, DOI: 10.1161/jaha.114.000898.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAgedChi-Square DistributionChronic DiseaseConnecticutCoronary CirculationCoronary DiseaseDepressionFemaleHemodynamicsHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisMyocardial Perfusion ImagingOdds RatioPredictive Value of TestsPsychiatric Status Rating ScalesRecurrenceRisk FactorsSeverity of Illness IndexStress, PsychologicalTomography, Emission-Computed, Single-PhotonConceptsAcute psychological stressMyocardial perfusionPsychological stressDepressed rangeNormal rangeAcute coronary syndrome (ACS) recurrenceSelective serotonin reuptake inhibitor medicationsStable coronary heart diseaseCoronary heart disease patientsSerotonin reuptake inhibitor medicationsImpaired myocardial perfusionTomography myocardial perfusionCoronary heart diseaseMortality risk factorsOptimal medical careHigh normal rangeReuptake inhibitor medicationsHeart disease patientsBeck Depression InventorySingle photon emissionACS recurrenceCHD prognosisInhibitor medicationVascular mechanismsMeasures of depression
2013
Therapy for Mental Stress–Induced Myocardial Ischemia
Burg MM, Soufer R. Therapy for Mental Stress–Induced Myocardial Ischemia. JAMA 2013, 310: 1400-1401. PMID: 24084926, DOI: 10.1001/jama.2013.277951.Peer-Reviewed Original Research
2011
Cardiac repolarization instability during psychological stress in patients with ventricular arrhythmias
Abisse SS, Lampert R, Burg M, Soufer R, Shusterman V. Cardiac repolarization instability during psychological stress in patients with ventricular arrhythmias. Journal Of Electrocardiology 2011, 44: 678-683. PMID: 21920534, PMCID: PMC3200452, DOI: 10.1016/j.jelectrocard.2011.07.019.Peer-Reviewed Original ResearchConceptsSubsequent ventricular tachyarrhythmiasVentricular tachyarrhythmiasGroup 2Group 1Life-threatening ventricular tachyarrhythmiasPsychological stressSubsequent arrhythmic eventsAutonomic nervous system activityNervous system activityCardiac repolarization instabilityICD implantationVentricular arrhythmiasArrhythmic eventsQT intervalRepolarization responseCardiac repolarizationHeart ratePatientsT-wave areaPsychological stressorsMental stressRepolarization instabilityCardiac physiologySystem activitySignificant differencesAutonomic Contribution to Endothelin-1 Increase during Laboratory Anger-Recall Stress in Patients with Coronary Artery Disease
Burg MM, Soufer A, Lampert R, Collins D, Soufer R. Autonomic Contribution to Endothelin-1 Increase during Laboratory Anger-Recall Stress in Patients with Coronary Artery Disease. Molecular Medicine 2011, 17: 495-501. PMID: 21267513, PMCID: PMC3105151, DOI: 10.2119/molmed.2010.00083.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseEndothelin-1Parasympathetic activityArtery diseaseAutonomic contributionsChronic stable coronary artery diseaseStable coronary artery diseaseCholinergic antiinflammatory pathwayLaboratory stressCoronary plaque ruptureEndothelin-1 increaseSignificant odds ratioEndothelial cell functionCardiac eventsEndothelial dysfunctionIndwelling catheterAutonomic factorsSympathetic activityAntiinflammatory pathwayAutonomic influencesAutonomic toneOdds ratioPlaque ruptureParasympathetic withdrawalHemodynamic monitor
2010
Depression Predicts Elevated Endothelin-1 in Patients With Coronary Artery Disease
Burg MM, Martens EJ, Collins D, Soufer R. Depression Predicts Elevated Endothelin-1 in Patients With Coronary Artery Disease. Psychosomatic Medicine 2010, 73: 2-6. PMID: 20947777, PMCID: PMC3016462, DOI: 10.1097/psy.0b013e3181fdfb25.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseEndothelin-1Beck Depression InventoryBDI scoresLogistic regression modelsArtery diseaseLog-transformed continuous variableRisk thresholdElevated endothelin-1ET-1 elevationET-1 levelsEvent-free survivalMorning blood samplesWorse depression symptomsDepression symptom severityEarly morbidityRegression modelsPoor survivalPlaque ruptureAdjusted modelBlood samplesDepressive symptomsDepression severityDepression symptomsDepression InventoryTendency to Angry Rumination Predicts Stress-Provoked Endothelin-1 Increase in Patients With Coronary Artery Disease
Fernandez AB, Soufer R, Collins D, Soufer A, Ranjbaran H, Burg MM. Tendency to Angry Rumination Predicts Stress-Provoked Endothelin-1 Increase in Patients With Coronary Artery Disease. Psychosomatic Medicine 2010, 72: 348-353. PMID: 20368479, PMCID: PMC2872076, DOI: 10.1097/psy.0b013e3181d71982.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseET-1 increaseET-1Chronic stable coronary heart diseaseStable coronary heart diseaseMultivariate logistic regression modelET-1 elevationAcute coronary syndromeHistory of diabetesRate-pressure productCoronary artery diseaseEndothelin-1 increaseLogistic regression modelsCoronary syndromeArtery diseaseBeta blockersPotential confoundersPressure productHeart diseasePlaque ruptureBlood samplesPatientsAngry ruminationNitric oxideStress protocol
2009
Heart-brain interactions in mental stress-induced myocardial ischemia
Soufer R, Jain H, Yoon AJ. Heart-brain interactions in mental stress-induced myocardial ischemia. Current Cardiology Reports 2009, 11: 133-140. PMID: 19236829, PMCID: PMC3726062, DOI: 10.1007/s11886-009-0020-1.Peer-Reviewed Original ResearchConceptsMental stress ischemiaStress ischemiaMyocardial ischemiaMental stress-induced myocardial ischemiaStress-induced myocardial ischemiaCoronary artery diseaseCentral nervous systemHeart-brain interactionsArtery diseasePoor prognosisAutonomic balancePathophysiologic underpinningsTreatment strategiesNervous systemIschemiaPsychosocial stressBiobehavioral aspectsBiobehavioral modelBiologic consequencesSensory inputBiologic processesBrainEmotional provocationPatientsPrognosisAnger-Induced T-Wave Alternans Predicts Future Ventricular Arrhythmias in Patients With Implantable Cardioverter-Defibrillators
Lampert R, Shusterman V, Burg M, McPherson C, Batsford W, Goldberg A, Soufer R. Anger-Induced T-Wave Alternans Predicts Future Ventricular Arrhythmias in Patients With Implantable Cardioverter-Defibrillators. Journal Of The American College Of Cardiology 2009, 53: 774-778. PMID: 19245968, PMCID: PMC3979284, DOI: 10.1016/j.jacc.2008.10.053.Peer-Reviewed Original ResearchConceptsVentricular tachycardia/ventricular fibrillationFuture ventricular arrhythmiasT-wave alternansVentricular arrhythmiasVentricular fibrillationSpontaneous ventricular tachycardia/ventricular fibrillationHigher TWAImplantable cardioverter defibrillatorEjection fractionHighest quartileTWA testingWide QRSClinical arrhythmiaAmbulatory electrocardiographyLowest quartileFuture arrhythmiasSudden deathCardioverter defibrillatorClinical roleMultivariable regressionPatientsArrhythmiasRepolarization instabilityStress protocolSignificant predictors
2008
Noninvasive Detection of Risk for Emotion Provoked Myocardial Ischemia
Burg MM, Graeber B, Vashist A, Collins D, Earley C, Liu J, Lampert R, Soufer R. Noninvasive Detection of Risk for Emotion Provoked Myocardial Ischemia. Psychosomatic Medicine 2008, 71: 14-20. PMID: 18941131, PMCID: PMC2739989, DOI: 10.1097/psy.0b013e318187c035.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngerAngiotensin-Converting Enzyme InhibitorsBlood PressureCoronary DiseaseEpinephrineFemaleHeart RateHumansImagery, PsychotherapyMaleManometryMiddle AgedMyocardial IschemiaNorepinephrinePlethysmographyPredictive Value of TestsPulsatile FlowRiskSensitivity and SpecificityStress, PsychologicalTomography, Emission-Computed, Single-PhotonVascular ResistanceConceptsPeripheral arterial tonometryCoronary artery diseasePAT ratioMyocardial ischemiaMajor adverse cardiac eventsStable coronary artery diseaseLower PAT ratioMental stress ischemiaAdverse cardiac eventsNew perfusion defectsCT myocardial perfusionSensitivity/specificityStress ischemiaArterial tonometryCardiac eventsArtery diseaseBlood pressureACE inhibitionPerfusion defectsHeart rateMyocardial perfusionPatientsEnzyme inhibitorsClinical settingIschemia
2007
Implantable Cardioverter‐Defibrillator Shocks Increase T‐Wave Alternans
LAMPERT R, SOUFER R, McPHERSON CA, BATSFORD WP, TIRADO S, EARLEY C, GOLDBERG A, SHUSTERMAN V. Implantable Cardioverter‐Defibrillator Shocks Increase T‐Wave Alternans. Journal Of Cardiovascular Electrophysiology 2007, 18: 512-517. PMID: 17428273, DOI: 10.1111/j.1540-8167.2007.00787.x.Peer-Reviewed Original ResearchConceptsRepolarization instabilityQRS duration changesImplantable defibrillator shocksAmbulatory ECG monitoringT-wave alternansNorepinephrine levelsCoronary diseaseICD shocksSympathetic stimulationVentricular arrhythmiasInduced arrhythmiasVentricular arrhythmogenesisDefibrillator shocksQRS durationQT intervalSedated stateAdequate preClinical implicationsDefibrillation therapyECG monitoringRR intervalsHolter dataBaseline statePatientsArrhythmias
2006
C-Reactive Protein and Vulnerability to Mental Stress-Induced Myocardial Ischemia
Shah R, Burg MM, Vashist A, Collins D, Liu J, Jadbabaie F, Graeber B, Earley C, Lampert R, Soufer R. C-Reactive Protein and Vulnerability to Mental Stress-Induced Myocardial Ischemia. Molecular Medicine 2006, 12: 269-274. PMID: 17380191, PMCID: PMC1829194, DOI: 10.2119/2006-00077.shah.Peer-Reviewed Original ResearchConceptsC-reactive proteinCoronary artery diseaseMyocardial perfusion imagingTransthoracic echocardiographyCRP levelsMental stressRisk markersMyocardial ischemiaLevels of CRPNew regional wall motion abnormalitiesAssociation of CRPRelationship of CRPSimultaneous single-photon emissionStable coronary artery diseaseUnivariate logistic regression analysisRegional wall motion abnormalitiesTetrofosmin myocardial perfusion imagingLaboratory mental stressRisk of MSISerum CRP levelsHistory of diabetesSubsequent clinical eventsNew perfusion defectsWall motion abnormalitiesLogistic regression analysis
2005
Effects of Psychologic Stress on Repolarization and Relationship to Autonomic and Hemodynamic Factors
LAMPERT R, SHUSTERMAN V, BURG MM, LEE FA, EARLEY C, GOLDBERG A, MCPHERSON CA, BATSFORD WP, SOUFER R. Effects of Psychologic Stress on Repolarization and Relationship to Autonomic and Hemodynamic Factors. Journal Of Cardiovascular Electrophysiology 2005, 16: 372-377. PMID: 15828878, DOI: 10.1046/j.1540-8167.2005.40580.x.Peer-Reviewed Original ResearchConceptsT-wave alternansMental stressVentricular arrhythmiasPsychological stressAmbulatory ECG monitoringT-wave amplitudePathophysiologic linkSusceptible patientsSystolic BPRepolarization indicesAlters indicesPsychologic stressRepolarization changesSudden deathPatientsHemodynamic factorsT-wave areaStress protocolECG monitoringArrhythmiasPhysiologic pathwaysRepolarizationMyocardial heterogeneityICDHr
2003
MRI and PET Study of Deficits in Hippocampal Structure and Function in Women With Childhood Sexual Abuse and Posttraumatic Stress Disorder
Bremner JD, Vythilingam M, Vermetten E, Southwick SM, McGlashan T, Nazeer A, Khan S, Vaccarino LV, Soufer R, Garg PK, Ng CK, Staib LH, Duncan JS, Charney DS. MRI and PET Study of Deficits in Hippocampal Structure and Function in Women With Childhood Sexual Abuse and Posttraumatic Stress Disorder. American Journal Of Psychiatry 2003, 160: 924-932. PMID: 12727697, DOI: 10.1176/appi.ajp.160.5.924.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderChildhood sexual abuseHippocampal volumeEarly childhood sexual abuseHippocampal structureHippocampal functionAbuse-related posttraumatic stress disorderStress disorderSmaller hippocampal volumesPositron emission tomographySexual abuseVerbal declarative memory tasksAnimal studiesBrain areasDeclarative memory taskEmission tomographyPET studiesHippocampal activationWomenEarly stressHippocampusAbused womenDisordersAbuseMagnetic resonanceNeural correlates of declarative memory for emotionally valenced words in women with posttraumatic stress disorder related to early childhood sexual abuse
Bremner JD, Vythilingam M, Vermetten E, Southwick SM, McGlashan T, Staib LH, Soufer R, Charney DS. Neural correlates of declarative memory for emotionally valenced words in women with posttraumatic stress disorder related to early childhood sexual abuse. Biological Psychiatry 2003, 53: 879-889. PMID: 12742675, DOI: 10.1016/s0006-3223(02)01891-7.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderAbuse-related posttraumatic stress disorderMedial prefrontal cortexBrain areasPrefrontal cortexEarly childhood sexual abuseBlood flowChildhood abuse-related posttraumatic stress disorderSexual abuse-related posttraumatic stress disorderStress disorderChildhood sexual abuseCerebral blood flowPositron emission tomographic measurementsSpecific brain areasInferior temporal gyrusInferior parietal cortexMiddle frontal gyrusNeural correlatesTrauma-specific stimuliDeclarative memoryMotor cortexControl subjectsFrontal cortexSymptom provocationAnimal studies
2001
Reproducibility of in vivo brain measures of 5-HT2A receptors with PET and [18F]deuteroaltanserin
Soares J, van Dyck C, Tan P, Zoghbi S, Garg P, Soufer R, Baldwin R, Fujita M, Staley J, Fu X, Amici L, Seibyl J, Innis R. Reproducibility of in vivo brain measures of 5-HT2A receptors with PET and [18F]deuteroaltanserin. Psychiatry Research 2001, 106: 81-93. PMID: 11306248, DOI: 10.1016/s0925-4927(01)00071-3.Peer-Reviewed Original ResearchConceptsTest/retest reproducibilityPositron emission tomographyCortical brain areasIntra-class correlation coefficientRetest reproducibilityBrain areasBrain measuresHealthy human subjectsMean intra-class correlation coefficientOutcome measuresConstant infusionParent tracerBlood measurementsEmission tomographyNeuropsychiatric disordersPET measuresReceptorsHuman subjectsPET acquisitionMean intraEquilibrium imagingImaging methodInfusionBolusRTComparison of [18F]altanserin and [18F]deuteroaltanserin for PET imaging of serotonin2A receptors in baboon brain: pharmacological studies
Staley J, Van Dyck C, Tan P, Al Tikriti M, Ramsby Q, Klump H, Ng C, Garg P, Soufer R, Baldwin R, Innis R. Comparison of [18F]altanserin and [18F]deuteroaltanserin for PET imaging of serotonin2A receptors in baboon brain: pharmacological studies. Nuclear Medicine And Biology 2001, 28: 271-279. PMID: 11323237, DOI: 10.1016/s0969-8051(00)00212-2.Peer-Reviewed Original ResearchConceptsReceptor antagonist SR 46349BSerotonin2A receptorsSR 46349BReceptor radiotracerPharmacological specificityTime-activity curvesConstant infusionBaboon brainCortical activityDistribution volumePharmacological studiesPET imagingRadiotracerBrainReceptorsBaboonsPET imagesRegional distributionFenfluramineInfusionBolusGender differences in cognitive and neural correlates of remembrance of emotional words.
Bremner J, Soufer R, McCarthy G, Delaney R, Staib L, Duncan J, Charney D. Gender differences in cognitive and neural correlates of remembrance of emotional words. Psychopharmacology Bulletin 2001, 35: 55-78. PMID: 12397879.Peer-Reviewed Original ResearchConceptsEmotional wordsEmotional contentNeural correlatesWord pairsSuperior verbal memorySpecific cognitive functionsBilateral posterior hippocampusSuperior spatial memoryMedial prefrontal cortexGender differencesProcessing of informationNeutral wordsCognitive appraisalVerbal memoryPossible gender differencesHuman cognitionMemory performanceSet of listsGreater activationPosterior hippocampusPrefrontal cortexCognitive functionEmotional dimensionsSpatial memoryEmotional impact