2009
Heart-brain interactions in mental stress-induced myocardial ischemia
Soufer R, Jain H, Yoon AJ. Heart-brain interactions in mental stress-induced myocardial ischemia. Current Cardiology Reports 2009, 11: 133-140. PMID: 19236829, PMCID: PMC3726062, DOI: 10.1007/s11886-009-0020-1.Peer-Reviewed Original ResearchConceptsMental stress ischemiaStress ischemiaMyocardial ischemiaMental stress-induced myocardial ischemiaStress-induced myocardial ischemiaCoronary artery diseaseCentral nervous systemHeart-brain interactionsArtery diseasePoor prognosisAutonomic balancePathophysiologic underpinningsTreatment strategiesNervous systemIschemiaPsychosocial stressBiobehavioral aspectsBiobehavioral modelBiologic consequencesSensory inputBiologic processesBrainEmotional provocationPatientsPrognosis
2008
Noninvasive Detection of Risk for Emotion Provoked Myocardial Ischemia
Burg MM, Graeber B, Vashist A, Collins D, Earley C, Liu J, Lampert R, Soufer R. Noninvasive Detection of Risk for Emotion Provoked Myocardial Ischemia. Psychosomatic Medicine 2008, 71: 14-20. PMID: 18941131, PMCID: PMC2739989, DOI: 10.1097/psy.0b013e318187c035.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngerAngiotensin-Converting Enzyme InhibitorsBlood PressureCoronary DiseaseEpinephrineFemaleHeart RateHumansImagery, PsychotherapyMaleManometryMiddle AgedMyocardial IschemiaNorepinephrinePlethysmographyPredictive Value of TestsPulsatile FlowRiskSensitivity and SpecificityStress, PsychologicalTomography, Emission-Computed, Single-PhotonVascular ResistanceConceptsPeripheral arterial tonometryCoronary artery diseasePAT ratioMyocardial ischemiaMajor adverse cardiac eventsStable coronary artery diseaseLower PAT ratioMental stress ischemiaAdverse cardiac eventsNew perfusion defectsCT myocardial perfusionSensitivity/specificityStress ischemiaArterial tonometryCardiac eventsArtery diseaseBlood pressureACE inhibitionPerfusion defectsHeart rateMyocardial perfusionPatientsEnzyme inhibitorsClinical settingIschemia
2007
The heart-brain interaction during emotionally provoked myocardial ischemia: implications of cortical hyperactivation in CAD and gender interactions.
Soufer R, Burg MM. The heart-brain interaction during emotionally provoked myocardial ischemia: implications of cortical hyperactivation in CAD and gender interactions. Cleveland Clinic Journal Of Medicine 2007, 74 Suppl 1: s59-62. PMID: 17455547, DOI: 10.3949/ccjm.74.suppl_1.s59.Peer-Reviewed Original ResearchConceptsMental stress-induced ischemiaStress-induced ischemiaMental stressMyocardial ischemiaAcute coronary syndromeRecurrent cardiac eventsSilent myocardial ischemiaRisk stratification algorithmLong-term outcomesTreatment of patientsHeart-brain interactionsDifferential pathophysiologyCoronary syndromeCardiac eventsRisk stratificationPoor prognosisTransient ischemiaVulnerable patientsStratification algorithmCortical hyperactivationEarly deathIschemiaDiagnostic testingClinical settingClinical goals
2005
Mental stress ischemia: Present status and future goals
Burg MM, Vashist A, Soufer R. Mental stress ischemia: Present status and future goals. Journal Of Nuclear Cardiology 2005, 12: 523-529. PMID: 16171711, DOI: 10.1016/j.nuclcard.2005.06.085.Peer-Reviewed Original ResearchConceptsEvent-free survival rateLarge-scale clinical trialsAssessment of prognosisForms of ischemiaComplex clinical manifestationsSubstantial clinical impactClinical manifestationsPrognostic significanceClinical trialsClinical impactSurvival rateDiagnostic standardizationTreatment effectsIschemiaNuclear cardiologyPrognosisPathophysiologySufficient evidenceAdditional modalitiesTrialsFurther testingTreatmentPrevalenceCardiology
2004
Differential impact of parasympathetic withdrawal to mental stress ischemia as assessed by noninvasive evaluation of myocardial perfusion and/or function
Vashist A, Arrighi J, Lampert R, Burg M, Soufer R. Differential impact of parasympathetic withdrawal to mental stress ischemia as assessed by noninvasive evaluation of myocardial perfusion and/or function. Journal Of Nuclear Cardiology 2004, 11: s21. DOI: 10.1016/j.nuclcard.2004.06.068.Peer-Reviewed Original ResearchChronic coronary artery diseaseRegional LV dysfunctionMyocardial ischemiaParasympathetic withdrawalLV dysfunctionChronic chronic coronary artery diseaseMental stress ischemiaRate-pressure productCoronary artery diseaseGreater parasympathetic withdrawalHigh-frequency powerStress ischemiaArtery diseaseNon-invasive imagingMPI defectsSympathovagal balanceIndividual patientsSPECT-MPIIschemiaMyocardial perfusionNoninvasive evaluationPatientsMental arithmetic taskAutonomic responsesSPECT defects