2023
Impact of multi-site clinical trial results on clinical practice: Use of risperidone to treat PTSD nationally in the veterans health administration
Rosenheck R, Kurtz S, Anand S, Hau C, Smedberg D, Sicilia R, Pontzer J, Ferguson R. Impact of multi-site clinical trial results on clinical practice: Use of risperidone to treat PTSD nationally in the veterans health administration. Psychiatry Research 2023, 321: 115071. PMID: 36720177, DOI: 10.1016/j.psychres.2023.115071.Peer-Reviewed Original ResearchConceptsClinical practiceNational VHA administrative dataOral second-generation antipsychoticsUse of risperidoneVHA administrative dataSecond-generation antipsychoticsMulti-site clinical trialVeterans Health AdministrationClinical trialsEffectiveness trialHealth AdministrationRisperidoneCooperative StudyYear of publicationAdministrative dataPTSDTrialsYearsAntipsychoticsStudy resultsAdministration
2009
Developing A Policy For Second-Generation Antipsychotic Drugs
Rosenheck RA, Sernyak MJ. Developing A Policy For Second-Generation Antipsychotic Drugs. Health Affairs 2009, 28: w782-w793. PMID: 19622538, DOI: 10.1377/hlthaff.28.5.w782.Peer-Reviewed Original ResearchConceptsSecond-generation antipsychoticsAntipsychotic drugsRisk/benefit profileSecond-generation antipsychotic drugsMetabolic side effectsTreatment of schizophreniaAdverse eventsBenefit profileLower riskOld drugsSide effectsPrior authorizationDrugsCheaper drugsGeneric drugsEducational preparationWidespread implementationGood acceptanceSuch proceduresAntipsychoticsPatientsTherapySchizophrenia
2007
Generic Fluoxetine and Choice of Antidepressant Medication
Sernyak M, Rosenheck R. Generic Fluoxetine and Choice of Antidepressant Medication. Psychiatric Services 2007, 58: 128-130. PMID: 17215423, DOI: 10.1176/ps.2007.58.1.128.Peer-Reviewed Original Research
2006
Special Section on CATIE Baseline Data: Components and Correlates of Family Burden in Schizophrenia
Perlick D, Rosenheck R, Kaczynski R, Swartz M, Cañive J, Lieberman J. Special Section on CATIE Baseline Data: Components and Correlates of Family Burden in Schizophrenia. Psychiatric Services 2006, 57: 1117-1125. PMID: 16870962, DOI: 10.1176/ps.2006.57.8.1117.Peer-Reviewed Original ResearchConceptsMedication side effectsQuality of lifeDaily livingService useSide effectsAcute inpatient phaseImpact of symptomsPatient problem behaviorsClinical Antipsychotic TrialsPatient's symptomsCaregiver burdenInpatient phaseAntipsychotic TrialsFamily burdenFamily caregiversCaregiver dataPatient behaviorTreatment programPatients' impairmentIncorporation of skillsSymptomsIntervention effectivenessDemographic characteristicsPrevious monthSchizophreniaSpecial Section on CATIE Baseline Data: Baseline Use of Concomitant Psychotropic Medications to Treat Schizophrenia in the CATIE Trial
Chakos M, Glick I, Miller A, Hamner M, Miller D, Patel J, Tapp A, Keefe R, Rosenheck R. Special Section on CATIE Baseline Data: Baseline Use of Concomitant Psychotropic Medications to Treat Schizophrenia in the CATIE Trial. Psychiatric Services 2006, 57: 1094-1101. PMID: 16870959, DOI: 10.1176/ps.2006.57.8.1094.Peer-Reviewed Original ResearchConceptsConcomitant psychotropic medicationsPsychotropic medicationsConcomitant medication useIntervention Effectiveness (CATIE) trialOnly partial responseSecond-generation antipsychoticsBetter neurocognitive functioningClinical Antipsychotic TrialsPartial responseCATIE trialMedication useAnticholinergic drugsBaseline useMedication dataMood stabilizersCases symptomsConcomitant useEffectiveness trialAntipsychotic TrialsMedicationsNeurocognitive functioningSchizophreniaBaseline dataTrialsAntipsychoticsSpecial Section on CATIE Baseline Data: Interrelationships of Psychiatric Symptom Severity, Medical Comorbidity, and Functioning in Schizophrenia
Chwastiak L, Rosenheck R, McEvoy J, Keefe R, Swartz M, Lieberman J. Special Section on CATIE Baseline Data: Interrelationships of Psychiatric Symptom Severity, Medical Comorbidity, and Functioning in Schizophrenia. Psychiatric Services 2006, 57: 1102-1109. PMID: 16870960, DOI: 10.1176/ps.2006.57.8.1102.Peer-Reviewed Original ResearchConceptsMedical comorbiditiesMedical conditionsPsychiatric symptom severityPsychosocial functioningNeurocognitive impairmentSchizophrenia symptomsBaseline dataSymptom severityCross-sectional studyPhysical health statusSample of patientsClinical Antipsychotic TrialsPoorer neurocognitive functioningGreater depressive symptomsSevere schizophrenia symptomsSample of personsDiabetes mellitusAntipsychotic pharmacotherapyIndependent associationAntipsychotic TrialsMultivariate regression modelComorbiditiesPsychotic symptomsDepressive symptomsHealth status
2003
Cost-effectiveness of Supported Housing for Homeless Persons With Mental Illness
Rosenheck R, Kasprow W, Frisman L, Liu-Mares W. Cost-effectiveness of Supported Housing for Homeless Persons With Mental Illness. JAMA Psychiatry 2003, 60: 940-951. PMID: 12963676, DOI: 10.1001/archpsyc.60.9.940.Peer-Reviewed Original ResearchMeSH KeywordsAdultCase ManagementCommunity-Institutional RelationsCost of IllnessCost-Benefit AnalysisFemaleFinancing, GovernmentGovernment AgenciesHealth Care CostsHealth StatusHumansIll-Housed PersonsMaleMental DisordersProgram EvaluationProspective StudiesPublic HousingSocial AdjustmentSubstance-Related DisordersUnited StatesUnited States Department of Veterans AffairsVeteransConceptsStandard care groupIntensive case managementStandard careCase managementCare groupMore daysMental illnessVeterans AffairsIncremental cost-effectiveness ratioSuperior housing outcomesSubstance abuse statusHUD-VASHMental health statusSubstance abuse disordersCost-effectiveness ratioCommunity adjustmentMental illness resultsSupported housing programsSecondary outcomesPrimary outcomeAbuse disordersIllness resultsControl groupHealth statusSocietal perspective
2001
Stages in the Implementation of Innovative Clinical Programs in Complex Organizations
ROSENHECK R. Stages in the Implementation of Innovative Clinical Programs in Complex Organizations. The Journal Of Nervous And Mental Disease 2001, 189: 812-821. PMID: 11794574, DOI: 10.1097/00005053-200112000-00002.Peer-Reviewed Original ResearchMental and Physical Health and Acculturation among Hispanic Vietnam Veterans
Ortega A, Rosenheck R. Mental and Physical Health and Acculturation among Hispanic Vietnam Veterans. Military Medicine 2001, 166: 894-897. PMID: 11603242, DOI: 10.1093/milmed/166.10.894.Peer-Reviewed Original ResearchConceptsPhysical health risksHispanic Vietnam veteransHispanic veteransPhysical healthVietnam veteransNon-Hispanic whitesHealth risksOutcome measuresSecondary data analysisAcculturation indexEpidemiological studiesHealth outcomesMental healthVeteransMexican AmericansHealthAcculturation scoresRepresentative samplePredictive validityHispanicsPuerto RicansScoresRiskVietnam eraAssociationUse of Pharmacy Data to Assess Quality of Pharmacotherapy for Schizophrenia in a National Health Care System
Leslie D, Rosenheck R. Use of Pharmacy Data to Assess Quality of Pharmacotherapy for Schizophrenia in a National Health Care System. Medical Care 2001, 39: 923-933. PMID: 11502950, DOI: 10.1097/00005650-200109000-00003.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAdultAntipsychotic AgentsComorbidityDelivery of Health Care, IntegratedDiagnosis, Dual (Psychiatry)FemaleGuideline AdherenceHumansMaleMental Health ServicesMiddle AgedNational Health ProgramsOutcome and Process Assessment, Health CarePatient CompliancePolypharmacyPractice Guidelines as TopicSchizophreniaUnited StatesUnited States Department of Veterans AffairsConceptsPatient Outcomes Research TeamLarger mental health systemMultiple antipsychotic medicationsAntipsychotic medicationPORT recommendationsSchizophrenia Patient Outcomes Research TeamVeterans AffairsHealth systemTotal weekly doseTreatment of schizophreniaPrescription drug recordsMental health systemHealth care systemGeneralized estimation equationsMultiple antipsychoticsNational Health SystemOlder patientsWeekly doseNational health care systemPharmacy dataComorbid depressionTreatment recommendationsDrug recordsMedicationsPatientsThe Effect of Institutional Fiscal Stress on the Use of Atypical Antipsychotic Medications in the Treatment of Schizophrenia
LESLIE D, ROSENHECK R. The Effect of Institutional Fiscal Stress on the Use of Atypical Antipsychotic Medications in the Treatment of Schizophrenia. The Journal Of Nervous And Mental Disease 2001, 189: 377-383. PMID: 11434638, DOI: 10.1097/00005053-200106000-00005.Peer-Reviewed Original ResearchMeSH KeywordsAlzheimer DiseaseAntipsychotic AgentsBenzodiazepinesBudgetsClozapineComorbidityDepressive DisorderDrug CostsFemaleHealth Care CostsHealth FacilitiesHumansMaleMiddle AgedOlanzapinePirenzepinePractice Patterns, Physicians'Regression AnalysisRisperidoneSchizophreniaTreatment OutcomeUnited StatesUnited States Department of Veterans AffairsConceptsAtypical antipsychotic medicationsTreatment of schizophreniaAtypical antipsychoticsAntipsychotic medicationExpensive atypical antipsychotic medicationsVeterans AffairsPrescription drug recordsGeneralized estimation equationsDrug recordsPatientsReduced likelihoodAntipsychoticsMedicationsFacility characteristicsSchizophreniaAtypicalsFinal sampleTreatmentOlanzapineRisperidoneCombat Trauma: Trauma with Highest Risk of Delayed Onset and Unresolved Posttraumatic Stress Disorder Symptoms, Unemployment, and Abuse Among Men
PRIGERSON H, MACIEJEWSKI P, ROSENHECK R. Combat Trauma: Trauma with Highest Risk of Delayed Onset and Unresolved Posttraumatic Stress Disorder Symptoms, Unemployment, and Abuse Among Men. The Journal Of Nervous And Mental Disease 2001, 189: 99-108. PMID: 11225693, DOI: 10.1097/00005053-200102000-00005.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderForms of dysfunctionWorst traumaComposite International Diagnostic InterviewRisk of PTSDPTSD symptom onsetLifetime posttraumatic stress disorderDiagnostic Interview ScheduleNational Comorbidity SurveyPosttraumatic stress disorder (PTSD) symptomsSymptom onsetPersons 15PTSD moduleHigh riskDiagnostic InterviewDelayed onsetStress disorderTraumaPTSD symptomsDisorder symptomsMenRepresentative national sampleCombat traumaDysfunctionSymptoms
2000
Military Discharge Status of Homeless Veterans with Mental Illness
Gamache G, Rosenheck R, Tessler R. Military Discharge Status of Homeless Veterans with Mental Illness. Military Medicine 2000, 165: 803-808. PMID: 11143423, DOI: 10.1093/milmed/165.11.803.Peer-Reviewed Original ResearchAcculturation and the Lifetime Risk of Psychiatric and Substance Use Disorders among Hispanics
ORTEGA A, ROSENHECK R, ALEGRÍA M, DESAI R. Acculturation and the Lifetime Risk of Psychiatric and Substance Use Disorders among Hispanics. The Journal Of Nervous And Mental Disease 2000, 188: 728-735. PMID: 11093374, DOI: 10.1097/00005053-200011000-00002.Peer-Reviewed Original ResearchConceptsSubstance use disordersNational Comorbidity SurveyUse disordersLifetime riskGreater riskSubstance abuse disordersNon-Hispanic whitesMexican AmericansMultivariate adjustmentRisk factorsAbuse disordersPsychiatric disordersPsychiatric diagnosisIllness increasesSociodemographic characteristicsDSM-IIIU.S. adultsDisordersHispanic subgroupsAmerican SocietyParental nativityNational probability sampleRiskHispanicsProbability sampleRelationship Between Climate and Psychiatric Inpatient Length of Stay in Veterans Health Administration Hospitals
Federman E, Drebing C, Boisvert C, Penk W, Binus G, Rosenheck R. Relationship Between Climate and Psychiatric Inpatient Length of Stay in Veterans Health Administration Hospitals. American Journal Of Psychiatry 2000, 157: 1669-1673. PMID: 11007722, DOI: 10.1176/appi.ajp.157.10.1669.Peer-Reviewed Original ResearchConceptsVeterans Health Administration hospitalsLength of stayVHA hospitalsAdministration HospitalInpatient psychiatric lengthPsychiatric hospitalization costsPsychiatric Inpatient LengthHealth care utilizationLonger lengthInpatient psychiatric servicesHigh clinical costsCare utilizationHospitalization costsInpatient lengthPsychiatric lengthHospital utilizationMedical CenterPsychiatric servicesHospital levelStayHospitalClinical costsMean lengthSignificant correlationShorter lengthPrimary care satellite clinics and improved access to general and mental health services.
Rosenheck R. Primary care satellite clinics and improved access to general and mental health services. Health Services Research 2000, 35: 777-90. PMID: 11055448, PMCID: PMC1089152.Peer-Reviewed Original ResearchConceptsCommunity-based primary care clinicsVA mental health servicesPrimary care clinicsGeneral health care servicesMental health servicesHealth care servicesMental health componentCare clinicsProportion of veteransHealth servicesCare servicesHealth care componentNew clinicCare componentsHealth componentVeterans AffairsVA compensationVA health care servicesComparison countiesHealth careGeneral health careGeneral veteran populationFY 1995Mental health careNew primary care clinicThe Case Management Relationship and Outcomes of Homeless Persons With Serious Mental Illness
Chinman M, Rosenheck R, Lam J. The Case Management Relationship and Outcomes of Homeless Persons With Serious Mental Illness. Psychiatric Services 2000, 51: 1142-1147. PMID: 10970917, DOI: 10.1176/appi.ps.51.9.1142.Peer-Reviewed Original ResearchConceptsSerious mental illnessCase managersClinical outcomesMental illnessHomeless personsHigh therapeutic allianceMental health servicesCase management relationshipIll homeless personsLow allianceHigher allianceGeneral life satisfactionOutcome dataCommunity careHealth servicesMultivariate analysisSignificant associationMonthsTherapeutic allianceBaselineOutcomesIllnessDaysLife satisfactionSupport programsComparing Consumer and Nonconsumer Provided Case Management Services for Homeless Persons with Serious Mental Illness
CHINMAN M, ROSENHECK R, LAM J, DAVIDSON L. Comparing Consumer and Nonconsumer Provided Case Management Services for Homeless Persons with Serious Mental Illness. The Journal Of Nervous And Mental Disease 2000, 188: 446-453. PMID: 10919704, DOI: 10.1097/00005053-200007000-00009.Peer-Reviewed Original ResearchConceptsMental health servicesCase managersHealth servicesSerious mental illnessCase management servicesCase management teamClinical outcomesMeasures of analysisAccess siteOutcome measuresMental illnessPresent study showConsumer providersOutcomes of servicesTime pointsAccess programClient outcomesHomeless personsOutcomesStaff ageCohortIllnessNonconsumersLarge sampleManagement servicesPreliminary Explorations of the Harmful Interactive Effects of Widowhood and Marital Harmony on Health, Health Service Use, and Health Care Costs1
Prigerson H, Maciejewski P, Rosenheck R. Preliminary Explorations of the Harmful Interactive Effects of Widowhood and Marital Harmony on Health, Health Service Use, and Health Care Costs1. The Gerontologist 2000, 40: 349-357. PMID: 10853529, DOI: 10.1093/geront/40.3.349.Peer-Reviewed Original ResearchChildhood Risk Factors for Criminal Justice Involvement in a Sample of Homeless People with Serious Mental Illness
DESAI R, LAM J, ROSENHECK R. Childhood Risk Factors for Criminal Justice Involvement in a Sample of Homeless People with Serious Mental Illness. The Journal Of Nervous And Mental Disease 2000, 188: 324-332. PMID: 10890340, DOI: 10.1097/00005053-200006000-00002.Peer-Reviewed Original ResearchConceptsChildhood risk factorsRisk factorsCriminal justice involvementMental illnessCurrent illness severityJustice involvementRecent criminal justice involvementSerious mental illnessConduct-disordered behaviorStrongest predictorDisorder behaviorsCriminal justice contactIll adultsIllness severityAdult criminal activityBaseline interviewMedical attentionSubstance-related chargeIll personsNational ratesIll peopleConduct disorderJustice contactProportion of arrestsAccess program