2021
Pain and smoking study (PASS): A comparative effectiveness trial of smoking cessation counseling for veterans with chronic pain
Bastian LA, Driscoll M, DeRycke E, Edmond S, Mattocks K, Goulet J, Kerns RD, Lawless M, Quon C, Selander K, Snow J, Casares J, Lee M, Brandt C, Ditre J, Becker W. Pain and smoking study (PASS): A comparative effectiveness trial of smoking cessation counseling for veterans with chronic pain. Contemporary Clinical Trials Communications 2021, 23: 100839. PMID: 34485755, PMCID: PMC8391053, DOI: 10.1016/j.conctc.2021.100839.Peer-Reviewed Original ResearchCognitive-behavioral interventionsBehavioral interventionsAdaptive coping strategiesPain-related anxietyChronic painSmoking studiesGreater pain intensityCoping strategiesMotivational interviewingSmoking cessationPain-related functional interferenceTelephone counseling interventionCounseling interventionNicotine replacement therapyMental health comorbiditiesComparative effectiveness trialRandomized clinical trialsParticipantsEffectiveness trialRelapse managementVeteransCessation counselingBaseline characteristicsHealth comorbiditiesMedian age
2015
Deficiencies in reporting of statistical methodology in recent randomized trials of nonpharmacologic pain treatments: ACTTION systematic review
Dworkin JD, McKeown A, Farrar JT, Gilron I, Hunsinger M, Kerns RD, McDermott MP, Rappaport BA, Turk DC, Dworkin RH, Gewandter JS. Deficiencies in reporting of statistical methodology in recent randomized trials of nonpharmacologic pain treatments: ACTTION systematic review. Journal Of Clinical Epidemiology 2015, 72: 56-65. PMID: 26597977, DOI: 10.1016/j.jclinepi.2015.10.019.Peer-Reviewed Original ResearchConceptsRandomized clinical trialsPain treatmentPrimary analysisSystematic reviewNonpharmacologic pain treatmentsRecent randomized trialsJournal of PainQuality of reportingHalf of studiesClinical trial publicationsPercent of studiesNoninterventional trialStatistical methodsPrimary outcomeRandomized trialsClinical trialsTrial publicationsPainTrial resultsTrialsStatistical methodologyTreatmentReviewDeficiencyReporting
2014
Effect of variability in the 7-day baseline pain diary on the assay sensitivity of neuropathic pain randomized clinical trials: An ACTTION study
Farrar JT, Troxel AB, Haynes K, Gilron I, Kerns RD, Katz NP, Rappaport BA, Rowbotham MC, Tierney AM, Turk DC, Dworkin RH. Effect of variability in the 7-day baseline pain diary on the assay sensitivity of neuropathic pain randomized clinical trials: An ACTTION study. Pain 2014, 155: 1622-1631. PMID: 24831421, DOI: 10.1016/j.pain.2014.05.009.Peer-Reviewed Original ResearchConceptsDiabetic peripheral neuropathyLikelihood of responseClinical trialsPostherpetic neuralgiaPainful diabetic peripheral neuropathyAddiction Clinical Trial TranslationsNetworks (ACTTION) public-private partnershipBaseline pain levelsPlacebo-treated groupRandomized clinical trialsAnalgesic clinical trialsPatient-level dataClinical trial dataExploratory logistic regressionAvailable baseline factorsNeuropathic painPain diaryPain levelsBaseline factorsPain therapyPeripheral neuropathyPatient sexPatients' baselinePain ratingsStudy protocol
2012
Considerations for improving assay sensitivity in chronic pain clinical trials: IMMPACT recommendations
Dworkin RH, Turk DC, Peirce-Sandner S, Burke LB, Farrar JT, Gilron I, Jensen MP, Katz NP, Raja SN, Rappaport BA, Rowbotham MC, Backonja M, Baron R, Bellamy N, Bhagwagar Z, Costello A, Cowan P, Fang WC, Hertz S, Jay GW, Junor R, Kerns RD, Kerwin R, Kopecky EA, Lissin D, Malamut R, Markman JD, McDermott MP, Munera C, Porter L, Rauschkolb C, Rice ASC, Sampaio C, Skljarevski V, Sommerville K, Stacey BR, Steigerwald I, Tobias J, Trentacosti AM, Wasan AD, Wells GA, Williams J, Witter J, Ziegler D. Considerations for improving assay sensitivity in chronic pain clinical trials: IMMPACT recommendations. Pain 2012, 153: 1148-1158. PMID: 22494920, DOI: 10.1016/j.pain.2012.03.003.Peer-Reviewed Original ResearchConceptsRecent randomized clinical trialsClinical trialsAnalgesic treatmentChronic pain clinical trialsPain clinical trialsAnalgesic drug developmentChronic pain treatmentChronic pain trialsRandomized clinical trialsAnalgesic clinical trialsNumber of patientsEvidence-based approachIMMPACT recommendationsPain treatmentPain trialsPharmacologic treatmentAnalgesic trialsPain assessmentAssay sensitivityEfficacious medicationsConsensus meetingNegative trialsImproved efficacyStudy designTrials
2009
The Development of an Integrated Treatment for Veterans with Comorbid Chronic Pain and Posttraumatic Stress Disorder
Otis JD, Keane TM, Kerns RD, Monson C, Scioli E. The Development of an Integrated Treatment for Veterans with Comorbid Chronic Pain and Posttraumatic Stress Disorder. Pain Medicine 2009, 10: 1300-1311. PMID: 19818040, DOI: 10.1111/j.1526-4637.2009.00715.x.Peer-Reviewed Original ResearchConceptsComorbid chronic painPosttraumatic stress disorderChronic painCognitive processing therapyCognitive behavioral therapyTreatment approachesVeterans Affairs Medical CenterStress disorderPilot studyChronic pain managementRandomized clinical trialsMeasures of painFormat of treatmentPatient workbookPain managementTherapy attendanceTreatment development processCommon symptomsClinical benefitClinical trialsMedical CenterPainPosttreatment evaluationBehavioral therapyPhysical disability
2008
A randomized clinical trial for women with vulvodynia: Cognitive-behavioral therapy vs. supportive psychotherapy
Masheb RM, Kerns RD, Lozano C, Minkin MJ, Richman S. A randomized clinical trial for women with vulvodynia: Cognitive-behavioral therapy vs. supportive psychotherapy. Pain 2008, 141: 31-40. PMID: 19022580, PMCID: PMC2728361, DOI: 10.1016/j.pain.2008.09.031.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapySupportive psychotherapyPain severityRandomized clinical trialsOne-year followGreater patient satisfactionGreater improvementSelf-management skillsClinical improvementPatient satisfactionPhysician examinationSexual functionMixed-effects modelingClinical trialsPsychosocial treatmentsBetter outcomesTreatment approachesVulvodyniaCBT conditionTreatment improvementOne-yearRelative efficacySignificant decreaseTreatment effectsWomen
2007
Using Interactive Voice Response to Measure Pain and Quality of Life
Heapy A, Sellinger J, Higgins D, Chatkoff D, Bennett T, Kerns R. Using Interactive Voice Response to Measure Pain and Quality of Life. Pain Medicine 2007, 8: s145-s154. DOI: 10.1111/j.1526-4637.2007.00378.x.Peer-Reviewed Original ResearchTransdermal fentanylQuality of lifeVA Connecticut Healthcare SystemChronic noncancer painRandomized clinical trialsAverage painNoncancer painOral opioidsPain controlChronic painPain interferenceInteractive voice response technologyMedication adherenceProspective dataClinical trialsParticipant adherenceSleep qualityPainSide effectsTreatment dataLarger studyRelative efficacyInteractive voice responseIVR technologyHealthcare system