2024
Comparison of the prevalence and associated factors of chronic kidney disease diagnosed by serum creatinine or cystatin C among young people living with HIV in Uganda
Nasuuna E, Tomlinson L, Kalyesubula R, Dziva Chikwari C, Castelnuovo B, Manabe Y, Nakanjako D, Weiss H. Comparison of the prevalence and associated factors of chronic kidney disease diagnosed by serum creatinine or cystatin C among young people living with HIV in Uganda. BMC Nephrology 2024, 25: 422. PMID: 39587464, PMCID: PMC11590532, DOI: 10.1186/s12882-024-03865-8.Peer-Reviewed Original ResearchConceptsAlbumin-creatinine ratioChronic kidney diseaseFactors associated with chronic kidney diseaseSerum creatinineAdjusted odds ratiosCystatin CKidney diseaseEarly diagnosisAssociated with chronic kidney diseasePrevalence of chronic kidney diseaseCompare serum creatinineCreatinine-based onesFactors of chronic kidney diseaseAssociated with high mortalityCases of chronic kidney diseaseDefinition of chronic kidney diseaseChronic kidney disease prevalenceCystatin C-based equationsCystatin C levelsEstimate adjusted odds ratiosMeasuring urinary albuminConfidence intervalsDiagnosis of chronic kidney diseaseMultivariate logistic regressionReduce disease progressionPrevalence of chronic kidney disease among young people living with HIV in Sub Saharan Africa: A systematic review and meta-analysis
Nasuuna E, Nanyeenya N, Kibirige D, Izudi J, Chikwari C, Kalyesubula R, Castelnuovo B, Tomlinson L, Weiss H. Prevalence of chronic kidney disease among young people living with HIV in Sub Saharan Africa: A systematic review and meta-analysis. PLOS ONE 2024, 19: e0301954. PMID: 39495780, PMCID: PMC11534254, DOI: 10.1371/journal.pone.0301954.Peer-Reviewed Original ResearchConceptsPrevalence of chronic kidney diseaseChronic kidney disease prevalenceCKD prevalenceSub-Saharan AfricaDefinition of chronic kidney diseaseChronic kidney diseaseMeta-analysisPublication biasGlomerular filtration rateSystematic reviewJoanna Briggs Institute checklistEligibility criteriaI-squared valuePooled prevalence of chronic kidney diseaseEstimates of CKD prevalenceAlbumin-to-creatinine ratioDerSimonian-Laird random-effects modelCross-sectional studyRisk of biasAfrican Journals OnlineAfrican Index MedicusCochran's Q testRandom-effects modelStandard definitionYoung peopleGlobal Perspective on Acute Kidney Injury in Uganda.
Kansiime G, Langoya D, Kalyesubula R. Global Perspective on Acute Kidney Injury in Uganda. Kidney360 2024 PMID: 39378101, DOI: 10.34067/kid.0000000611.Peer-Reviewed Original ResearchA-058 Biomarkers of Nephropathy and the Angiotensin Converting Enzyme Insertion and Deletion Gene Polymorphisms Among Type 2 Diabetes Mellitus Patients at a Tertiary Hospital in Uganda
Kiconco R, Kalyesubula R, Kiwanuka G. A-058 Biomarkers of Nephropathy and the Angiotensin Converting Enzyme Insertion and Deletion Gene Polymorphisms Among Type 2 Diabetes Mellitus Patients at a Tertiary Hospital in Uganda. Clinical Chemistry 2024, 70: hvae106.057. DOI: 10.1093/clinchem/hvae106.057.Peer-Reviewed Original ResearchSerum glucose levelsType 2 diabetes mellitus patientsIncreased serum glucose levelsDecreased serum glucose levelsGlycated hemoglobinGlucose levelsGene polymorphismsTriglyceride levelsMellitus patientsDD genotypeAdult type 2 diabetes mellitus patientsPeripheral blood genomic DNAType 2 diabetic patientsMbarara Regional Referral HospitalACE II genotypeAngiotensin converting enzyme insertionACE DD genotypeMultivariate logistic regressionBlood genomic DNARegional Referral HospitalACE ID genotypeCross-sectional studyACE polymorphismReferral hospitalII genotypeHigher prevalence of kidney function impairment among older people living with HIV in Uganda
Ssemasaazi A, Kalyesubula R, Manabe Y, Mbabazi P, Naikooba S, Ssekindi F, Nasuuna E, Byakika-Kibwika P, Castelnuovo B. Higher prevalence of kidney function impairment among older people living with HIV in Uganda. BMC Nephrology 2024, 25: 321. PMID: 39334034, PMCID: PMC11428404, DOI: 10.1186/s12882-024-03761-1.Peer-Reviewed Original ResearchConceptsKidney function impairmentChronic kidney diseaseAntiretroviral therapyOlder PLWHFunctional impairmentKidney functionKidney diseaseHIV-related inflammationProgression of kidney diseasePrevalence of proteinuriaMultivariate logistic regression modelBurden of chronic kidney diseaseMeasures of kidney functionDiagnosis of hypertensionCross-sectional studyConclusionsHIV infectionHIV-related clinical characteristicsClinical characteristicsInstitution of measuresLogistic regression modelsDiabetes mellitusFemale sexHIVProteinuriaPLWHProteinuria as a Critical Indicator of Kidney Dysfunction in Type 2 Diabetes Patients: Insights From a Cross-Sectional Study
Kiconco R, Okoboi J, Mwesige S, Muwonge K, Kinobe R, Kalyesubula R, Kiwanuka G. Proteinuria as a Critical Indicator of Kidney Dysfunction in Type 2 Diabetes Patients: Insights From a Cross-Sectional Study. Cureus 2024, 16: e69946. PMID: 39445274, PMCID: PMC11496046, DOI: 10.7759/cureus.69946.Peer-Reviewed Original ResearchInternational equity in access to home dialysis.
Iyengar A, Kalyesubula R, Darwish R, Luyckx V. International equity in access to home dialysis. Current Opinion In Nephrology & Hypertension 2024 PMID: 39282856, DOI: 10.1097/mnh.0000000000001027.Peer-Reviewed Original ResearchHome dialysisIn-centreMiddle-income countriesIn-centre haemodialysisDrivers of inequalityHealth systemLack of resourcesCommunity partnersPatient levelEquitable accessPeritoneal dialysisHomeHealthCliniciansGeopolitical levelNursesPatientsIn-centre dialysisAccessInequalityDoctorsLackDialysisReducing global inequalityCountriesDiagnostic performance of an albuminuria point-of-care test in screening for chronic kidney disease among young people living with HIV in Uganda: a cross-sectional study
Nasuuna E, Kalyesubula R, Tomlinson L, Castelnuovo B, Okello E, Chikwari C, Weiss H. Diagnostic performance of an albuminuria point-of-care test in screening for chronic kidney disease among young people living with HIV in Uganda: a cross-sectional study. BMJ Open 2024, 14: e083221. PMID: 39153770, PMCID: PMC11331864, DOI: 10.1136/bmjopen-2023-083221.Peer-Reviewed Original ResearchConceptsPositive POC testCross-sectional studyChronic kidney diseaseDiagnostic performancePoint-of-care testingKidney diseaseHIV clinicPOC testingPOC testsBody mass index <Albumin-creatinine ratioPositive predictive valueUrinary excretion rateDiagnosis of chronic kidney diseaseYoung peopleYears of ageTherapy to adultsYPLHIVUrine dipstickCreatinine ratioDiagnosis of albuminuriaLogistic regressionPrimary outcomeAlbuminuriaHIVIncidence of Acute Kidney Injury and Associated Mortality among Individuals with Drug-Susceptible Tuberculosis in Uganda
Kansiime G, Aklilu A, Baluku J, Yasmin F, Kanyesigye M, Muzoora C, Wilson F, Bajunirwe F, Brewster U, Kalyesubula R. Incidence of Acute Kidney Injury and Associated Mortality among Individuals with Drug-Susceptible Tuberculosis in Uganda. Kidney360 2024, 5: 1446-1454. PMID: 39141693, PMCID: PMC11556924, DOI: 10.34067/kid.0000000000000551.Peer-Reviewed Original ResearchIncidence of acute kidney injuryAcute kidney injuryDiagnosis periodKidney injuryKDIGO-defined acute kidney injuryKidney functionTB diagnosisPredictors of acute kidney injuryTime to TB diagnosisAssociated with significant risk of mortalityIndependent of HIV statusOverall incidence of AKIAssociated with increased mortality riskCohort study of adultsAssociated with higher oddsAssociated with significant mortalityDrug-susceptible TBDrug-susceptible tuberculosisObservational cohort study of adultsAssociated with significant riskHIV-negative participantsSignificant risk of mortalityObservational cohort studyStudy of adultsMonitoring kidney functionHealth-related quality of life and hypertension in people with HIV on long-term antiretroviral therapy in Uganda
Batte C, Semulimi A, Mukisa J, Nakabuye M, Nidoi J, Mukunya D, Ratanshi R, Castelnuovo B, Lamorde M, Meya D, Checkley W, Kalyesubula R, Siddharthan T, Babigumira J. Health-related quality of life and hypertension in people with HIV on long-term antiretroviral therapy in Uganda. PLOS ONE 2024, 19: e0306928. PMID: 39116145, PMCID: PMC11309503, DOI: 10.1371/journal.pone.0306928.Peer-Reviewed Original ResearchConceptsHealth-related quality of lifeHealth-related qualityQuality of lifeHRQoL scoresLong-term antiretroviral therapyAssociated with lower HRQoL scoresMedian health utility scorePhysical health scoresAntiretroviral therapyLower HRQOL scoresHealth utility scoresMedical Outcomes StudyEQ-5D-5LQuality-of-life assessmentManagement of PWHScores of peopleHealth scoresCompare HRQoLPlan early interventionsHRQoL dataHistory of smokingUrban clinicEQ-5DHRQoLUtility scoresThe Future of Kidney Care in Low- and Middle-Income Countries: Challenges, Triumphs, and Opportunities
Kalyesubula R, Aklilu A, Calice-Silva V, Kumar V, Kansiime G. The Future of Kidney Care in Low- and Middle-Income Countries: Challenges, Triumphs, and Opportunities. Kidney360 2024, 5: 1047-1061. PMID: 38922683, PMCID: PMC11296549, DOI: 10.34067/kid.0000000000000489.Peer-Reviewed Original ResearchKidney careMiddle-income countriesHealth system infrastructureResilient health care systemHealth care providersKidney healthHealth care systemChronic kidney diseaseCare providersUnique risk factorsHealth priorityCare systemLack of awarenessChronic diseasesGeneral populationCareLMICsKidney replacement therapyHealthRisk factorsGenetic predispositionEarly detectionMultidisciplinary followFinancing mechanismsHuman resourcesDistribution of the ACE Gene Polymorphisms in Type 2 Diabetes Mellitus Patients, Their Associations with Nephropathy Biomarkers and Metabolic Indicators at a Tertiary Hospital in Uganda
Kiconco R, Kalyesubula R, Kiwanuka G. Distribution of the ACE Gene Polymorphisms in Type 2 Diabetes Mellitus Patients, Their Associations with Nephropathy Biomarkers and Metabolic Indicators at a Tertiary Hospital in Uganda. Diabetes Metabolic Syndrome And Obesity 2024, 17: 2211-2220. PMID: 38854447, PMCID: PMC11162639, DOI: 10.2147/dmso.s462740.Peer-Reviewed Original ResearchSerum glucose levelsType 2 diabetes mellitus patientsType 2 diabetic patientsIncreased serum glucose levelsDecreased serum glucose levelsGlycated hemoglobinGlucose levelsGene polymorphismsNephropathy biomarkersTriglyceride levelsMellitus patientsDD genotypeMetabolic indicatorsAdult type 2 diabetes mellitus patientsPeripheral blood genomic DNAMbarara Regional Referral HospitalACE II genotypeACE gene polymorphismACE DD genotypeBlood genomic DNAMultivariate logistic regressionRegional Referral HospitalACE ID genotypeSerum creatinineReferral hospitalAirway microbiome signature accurately discriminates Mycobacterium tuberculosis infection status
Kayongo A, Ntayi M, Olweny G, Kyalo E, Ndawula J, Ssengooba W, Kigozi E, Kalyesubula R, Munana R, Namaganda J, Caroline M, Sekibira R, Bagaya B, Kateete D, Joloba M, Jjingo D, Sande O, Mayanja-Kizza H. Airway microbiome signature accurately discriminates Mycobacterium tuberculosis infection status. IScience 2024, 27: 110142. PMID: 38904070, PMCID: PMC11187240, DOI: 10.1016/j.isci.2024.110142.Peer-Reviewed Original ResearchImmune responseQuantiferon-gold assayMicrobiome signaturesLonger treatment durationTuberculosis infection statusInfection statusDeadly infectious agentsQuantiferon GoldDrug toxicityActive TBLatent TBTreatment durationTherapeutic strategiesPredicting disease susceptibilityFollow-up phaseAirwayMicrobiome diversityInfectious agentsRural UgandaControl TBMycobacterium tuberculosisDisease susceptibilityCohortTuberculosisGeneXpertCapacity for the management of kidney failure in the International Society of Nephrology Africa region: report from the 2023 ISN Global Kidney Atlas (ISN-GKHA)
Tannor E, Davidson B, Nlandu Y, Bagasha P, Bilchut W, Davids M, Diongole H, Ekrikpo U, Hafiz E, Ibrahim K, Kalyesubula R, Nalado A, Olanrewaju T, Onu U, Pereira-Kamath N, Sakajiki A, Salah M, Vincent L, Arruebo S, Bello A, Caskey F, Damster S, Donner J, Jha V, Johnson D, Levin A, Malik C, Nangaku M, Okpechi I, Tonelli M, Ye F, Ashuntantang G, Arogundade F, Authors R, Gawad M, Abderrahim E, Akl A, Amekoudi E, Amouzegar A, Awobusuyi J, Bakoush O, Chissico E, Cho Y, Coker J, Cullis B, Dahwa R, Darwish R, Davison S, Divyaveer S, Ethier I, Fagoonee K, Fofana A, Freercks R, Fung W, Gandzali-Ngabe P, Ghimire A, Gouda Z, Habyarimana O, Htay H, Wan D, Irish G, Ismail W, Jagne A, Jarraya F, Jindal K, Kabllo B, Kalebi A, Folefack F, Kelly D, Lalji R, Lomatayo B, Mah S, Abderraman G, McCulloch M, Mengistu Y, Moloi M, Mwaba C, Neuen B, Ngigi J, Niang A, Nyandwi J, Odeh E, Osman M, Le Grand Ouanekpone C, Petrova A, Ranivoharisoa E, Riaz P, Saad S, See E, Sokwala A, Solarin A, Sozio S, Houssani T, Kiswaya E, Tia W, Tiv S, Ts'enoli T, Tungsanga S, Ulasi I, Vanglist S, Viecelli A, Wadee S, Wainstein M, Wearne N, Yeung E, Zaidi D. Capacity for the management of kidney failure in the International Society of Nephrology Africa region: report from the 2023 ISN Global Kidney Atlas (ISN-GKHA). Kidney International Supplements 2024, 13: 12-28. PMID: 38618494, PMCID: PMC11010621, DOI: 10.1016/j.kisu.2024.01.002.Peer-Reviewed Original ResearchHealth care workforceManagement of peopleCare workforceHealth systemKidney careWorld Health Organization building blocksIncreased out-of-pocket costsChronic kidney disease preventionGlobal Kidney Health AtlasBurden of chronic kidney diseaseOut-of-pocket costsKidney disease preventionHealth information dataHealth care workersChronic kidney diseaseManagement of kidney failureCare deliveryKidney disease managementNondialysis chronic kidney diseaseCare workersCare financingHealth infrastructureDisease preventionService deliveryKidney diseaseWCN24-758 RECOGNITION OF LOCAL INVESTIGATORS IN AUTHORSHIP OF COLLABORATIVE KIDNEY RESEARCH CONDUCTED IN LOW- AND LOWERMIDDLE INCOME COUNTRIES
Wijewickrama E, Chanchlani R, Wong M, Kumar V, Karam S, Chen T, Erikpo U, Tannor E, Calice-Silva V, Anandh U, Bajpai D, Hafidz M, Tian A, Opare-Addo P, Edeki I, Kalyesubula R. WCN24-758 RECOGNITION OF LOCAL INVESTIGATORS IN AUTHORSHIP OF COLLABORATIVE KIDNEY RESEARCH CONDUCTED IN LOW- AND LOWERMIDDLE INCOME COUNTRIES. Kidney International Reports 2024, 9: s55. DOI: 10.1016/j.ekir.2024.02.119.Peer-Reviewed Original ResearchHypertension Related Co-Morbidities and Complications in Women of Sub-Saharan Africa: A Brief Review
Hahka T, Slotkowski R, Akbar A, VanOrmer M, Sembajwe L, Ssekandi A, Namaganda A, Muwonge H, Kasolo J, Nakimuli A, Mwesigwa N, Ishimwe J, Kalyesubula R, Kirabo A, Berry A, Patel K. Hypertension Related Co-Morbidities and Complications in Women of Sub-Saharan Africa: A Brief Review. Circulation Research 2024, 134: 459-473. PMID: 38359096, PMCID: PMC10885774, DOI: 10.1161/circresaha.123.324077.Peer-Reviewed Original ResearchConceptsHypertensive disorders of pregnancyIncidence of hypertensive disorders of pregnancyCo-morbiditiesCardiovascular diseaseDisorders of pregnancyAwareness of hypertensionIndividual quality of lifeLong-term consequences of hypertensionRates of hypertensionPeripheral arterial diseaseLack of prevention programsQuality of lifeHypertensive disordersConsequences of hypertensionLives of womenDecrease morbidityTreatment strategiesUncontrolled hypertensionArtery diseaseKidney diseaseHypertensionPrevention programsKnowledge of causesHeart diseasePrevention strategiesSingle-sample measured glomerular filtration rate in Malawi, South Africa, and Uganda
Currin S, George J, Hansen C, Naicker S, Tomlinson L, Crampin A, Kalyesubula R, Newton R, Nakanga W, Nitsch D, Fabian J. Single-sample measured glomerular filtration rate in Malawi, South Africa, and Uganda. Kidney International 2024, 105: 882-885. PMID: 38307202, DOI: 10.1016/j.kint.2024.01.020.Peer-Reviewed Original ResearchChallenges to Implementing Environmentally Sustainable Kidney Care in LMICs: An Opinion Piece
Bajpai D, Hailu W, Bagasha P, Chika O, Hafiz E, Tannor E, Wijewickrama E, Kalyesubula R, Karam S, Calice-Silva V, Ethier I, Sandal S. Challenges to Implementing Environmentally Sustainable Kidney Care in LMICs: An Opinion Piece. Canadian Journal Of Kidney Health And Disease 2024, 11: 20543581241246835. PMID: 38774488, PMCID: PMC11107313, DOI: 10.1177/20543581241246835.Peer-Reviewed Original ResearchPrevalence and factors associated with hyperglycemia among persons living with HIV/AIDS on dolutegravir-based antiretroviral therapy in Uganda
Byereta L, Olum R, Mutebi E, Kalyesubula R, Kagimu M, Meya D, Andia-Biraro I. Prevalence and factors associated with hyperglycemia among persons living with HIV/AIDS on dolutegravir-based antiretroviral therapy in Uganda. Therapeutic Advances In Infectious Disease 2024, 11: 20499361241272630. PMID: 39286262, PMCID: PMC11403689, DOI: 10.1177/20499361241272630.Peer-Reviewed Original ResearchKiruddu National Referral HospitalFactors associated with hyperglycemiaDTG-based antiretroviral therapyFamily history of diabetesAntiretroviral therapyHerbal medicine useNational Referral HospitalMiddle-income countriesHistory of diabetesInfectious diseases outpatient clinicInpatient wardsDiabetes mellitusGt;40 yearsAssociated with ageDTG-based ART regimenElevated blood pressure levelsBlood pressure levelsReferral hospitalFamily historyBivariate analysisPre-diabetesPLHIVLogistic regressionAssociation guidelinesPertinent confounders
2023
Self-care and healthcare seeking practices among patients with hypertension and diabetes in rural Uganda
Tusubira A, Ssinabulya I, Kalyesubula R, Nalwadda C, Akiteng A, Ngaruiya C, Rabin T, Katahoire A, Armstrong-Hough M, Hsieh E, Hawley N, Schwartz J. Self-care and healthcare seeking practices among patients with hypertension and diabetes in rural Uganda. PLOS Global Public Health 2023, 3: e0001777. PMID: 38079386, PMCID: PMC10712841, DOI: 10.1371/journal.pgph.0001777.Peer-Reviewed Original Research