Prevalence of chronic kidney disease among young people living with HIV in Sub Saharan Africa: A systematic review and meta-analysis
Nasuuna E, Nanyeenya N, Kibirige D, Izudi J, Chikwari C, Kalyesubula R, Castelnuovo B, Tomlinson L, Weiss H. Prevalence of chronic kidney disease among young people living with HIV in Sub Saharan Africa: A systematic review and meta-analysis. PLOS ONE 2024, 19: e0301954. PMID: 39495780, PMCID: PMC11534254, DOI: 10.1371/journal.pone.0301954.Peer-Reviewed Original ResearchConceptsPrevalence of chronic kidney diseaseChronic kidney disease prevalenceCKD prevalenceSub-Saharan AfricaDefinition of chronic kidney diseaseChronic kidney diseaseMeta-analysisPublication biasGlomerular filtration rateSystematic reviewJoanna Briggs Institute checklistEligibility criteriaI-squared valuePooled prevalence of chronic kidney diseaseEstimates of CKD prevalenceAlbumin-to-creatinine ratioDerSimonian-Laird random-effects modelCross-sectional studyRisk of biasAfrican Journals OnlineAfrican Index MedicusCochran's Q testRandom-effects modelStandard definitionYoung peopleA-058 Biomarkers of Nephropathy and the Angiotensin Converting Enzyme Insertion and Deletion Gene Polymorphisms Among Type 2 Diabetes Mellitus Patients at a Tertiary Hospital in Uganda
Kiconco R, Kalyesubula R, Kiwanuka G. A-058 Biomarkers of Nephropathy and the Angiotensin Converting Enzyme Insertion and Deletion Gene Polymorphisms Among Type 2 Diabetes Mellitus Patients at a Tertiary Hospital in Uganda. Clinical Chemistry 2024, 70: hvae106.057. DOI: 10.1093/clinchem/hvae106.057.Peer-Reviewed Original ResearchSerum glucose levelsType 2 diabetes mellitus patientsIncreased serum glucose levelsDecreased serum glucose levelsGlycated hemoglobinGlucose levelsGene polymorphismsTriglyceride levelsMellitus patientsDD genotypeAdult type 2 diabetes mellitus patientsPeripheral blood genomic DNAType 2 diabetic patientsMbarara Regional Referral HospitalACE II genotypeAngiotensin converting enzyme insertionACE DD genotypeMultivariate logistic regressionBlood genomic DNARegional Referral HospitalACE ID genotypeCross-sectional studyACE polymorphismReferral hospitalII genotypeHigher prevalence of kidney function impairment among older people living with HIV in Uganda
Ssemasaazi A, Kalyesubula R, Manabe Y, Mbabazi P, Naikooba S, Ssekindi F, Nasuuna E, Byakika-Kibwika P, Castelnuovo B. Higher prevalence of kidney function impairment among older people living with HIV in Uganda. BMC Nephrology 2024, 25: 321. PMID: 39334034, PMCID: PMC11428404, DOI: 10.1186/s12882-024-03761-1.Peer-Reviewed Original ResearchConceptsKidney function impairmentChronic kidney diseaseAntiretroviral therapyOlder PLWHFunctional impairmentKidney functionKidney diseaseHIV-related inflammationProgression of kidney diseasePrevalence of proteinuriaMultivariate logistic regression modelBurden of chronic kidney diseaseMeasures of kidney functionDiagnosis of hypertensionCross-sectional studyConclusionsHIV infectionHIV-related clinical characteristicsClinical characteristicsInstitution of measuresLogistic regression modelsDiabetes mellitusFemale sexHIVProteinuriaPLWHProteinuria as a Critical Indicator of Kidney Dysfunction in Type 2 Diabetes Patients: Insights From a Cross-Sectional Study
Kiconco R, Okoboi J, Mwesige S, Muwonge K, Kinobe R, Kalyesubula R, Kiwanuka G. Proteinuria as a Critical Indicator of Kidney Dysfunction in Type 2 Diabetes Patients: Insights From a Cross-Sectional Study. Cureus 2024, 16: e69946. PMID: 39445274, PMCID: PMC11496046, DOI: 10.7759/cureus.69946.Peer-Reviewed Original ResearchType 2 diabetic patientsCross-sectional studyDiagnostic performance of an albuminuria point-of-care test in screening for chronic kidney disease among young people living with HIV in Uganda: a cross-sectional study
Nasuuna E, Kalyesubula R, Tomlinson L, Castelnuovo B, Okello E, Chikwari C, Weiss H. Diagnostic performance of an albuminuria point-of-care test in screening for chronic kidney disease among young people living with HIV in Uganda: a cross-sectional study. BMJ Open 2024, 14: e083221. PMID: 39153770, PMCID: PMC11331864, DOI: 10.1136/bmjopen-2023-083221.Peer-Reviewed Original ResearchConceptsPositive POC testCross-sectional studyChronic kidney diseaseDiagnostic performancePoint-of-care testingKidney diseaseHIV clinicPOC testingPOC testsBody mass index <Albumin-creatinine ratioPositive predictive valueUrinary excretion rateDiagnosis of chronic kidney diseaseYoung peopleYears of ageTherapy to adultsYPLHIVUrine dipstickCreatinine ratioDiagnosis of albuminuriaLogistic regressionPrimary outcomeAlbuminuriaHIV