2000
Airway Hyperresponsiveness and Airway Obstruction in Transgenic Mice
Kuhn C, Homer R, Zhu Z, Ward N, Flavell R, Geba G, Elias J. Airway Hyperresponsiveness and Airway Obstruction in Transgenic Mice. American Journal Of Respiratory Cell And Molecular Biology 2000, 22: 289-295. PMID: 10696065, DOI: 10.1165/ajrcmb.22.3.3690.Peer-Reviewed Original ResearchConceptsLittermate control miceTransgenic miceAirway obstructionControl miceIL-11Basal airway resistanceIL-6 (-/-) miceSubepithelial airway fibrosisObstructive lung diseasePathophysiology of asthmaAirway wall thicknessAirway fibrosisAirway hyperresponsivenessAirway reactivityMethacholine responsivenessAirway physiologyAirway responsesAirspace enlargementAirway resistanceCaliber changeIL-6Lung diseaseMononuclear cellsPulmonary disordersLuminal diameter
1994
Preparation, characterization, and evaluation of a monoclonal antibody against the rabbit platelet glycoprotein IIb/IIIa in an experimental angioplasty model.
Azrin MA, Ling FS, Chen Q, Pawashe A, Migliaccio F, Homer R, Todd M, Ezekowitz MD. Preparation, characterization, and evaluation of a monoclonal antibody against the rabbit platelet glycoprotein IIb/IIIa in an experimental angioplasty model. Circulation Research 1994, 75: 268-277. PMID: 8033340, DOI: 10.1161/01.res.75.2.268.Peer-Reviewed Original ResearchConceptsAntibody-treated groupBalloon angioplastyPlatelet inhibitionLuminal diameterPlatelet glycoprotein IIb/IIIa receptorControl groupGlycoprotein IIb/IIIa receptorIIb/IIIa receptorMonoclonal antibodiesPlatelet glycoprotein IIb/IIIaPotent platelet inhibitionMinimum luminal diameterInhibits platelet functionPathogenesis of restenosisGlycoprotein IIb/IIIaInfusion of salineSignificant differencesDeposition of plateletsIIb/IIIaQuantitative histological analysisSingle infusionVascular injurySecond infusionExperimental atherosclerosisFemoral artery