1986
Levels of thymidylate synthetase during normal culture growth of L1210 cells.
Cadman E, Heimer R. Levels of thymidylate synthetase during normal culture growth of L1210 cells. Cancer Research 1986, 46: 1195-8. PMID: 3943093.Peer-Reviewed Original Research
1985
Lack of enhanced cytotoxicity of cultured L1210 cells using folinic acid in combination with sequential methotrexate and fluorouracil
Danhauser L, Heimer R, Cadman E. Lack of enhanced cytotoxicity of cultured L1210 cells using folinic acid in combination with sequential methotrexate and fluorouracil. Cancer Chemotherapy And Pharmacology 1985, 15: 214-219. PMID: 3876889, DOI: 10.1007/bf00263888.Peer-Reviewed Original ResearchConceptsSequential methotrexateΜM methotrexateL1210 cellsSynergistic cell killingCultured L1210 cellsFolinic acidMTX pretreatmentMethotrexateL1210 cell growthAcid-precipitable materialHuman neoplasmsPresence of methotrexateFUraInhibitory effectElevated levelsEnhanced cytotoxicityCell killingCell fractionCytotoxicityDUrd incorporationInhibitionThymidylate synthetaseCell growthThymidylate synthesisCultured cells
1983
Modulation of fluoropyrimidine metabolism in L1210 cells by l-alanosine
Heimer R, Goldberg D, Cadman E. Modulation of fluoropyrimidine metabolism in L1210 cells by l-alanosine. Biochemical Pharmacology 1983, 32: 199-206. PMID: 6870949, DOI: 10.1016/0006-2952(83)90544-0.Peer-Reviewed Original Research
1981
Analysis of the thymidylate synthetase ternary complex by high-performance liquid steric exclusion chromatography
Heimer R, Cadman E. Analysis of the thymidylate synthetase ternary complex by high-performance liquid steric exclusion chromatography. Analytical Biochemistry 1981, 118: 322-327. PMID: 7337229, DOI: 10.1016/0003-2697(81)90589-3.Peer-Reviewed Original ResearchThe influence of methotrexate pretreatment on 5-fluorouracil metabolism in L1210 cells.
Cadman E, Heimer R, Benz C. The influence of methotrexate pretreatment on 5-fluorouracil metabolism in L1210 cells. Journal Of Biological Chemistry 1981, 256: 1695-1704. PMID: 6161926, DOI: 10.1016/s0021-9258(19)69863-7.Peer-Reviewed Original ResearchConceptsMethotrexate pretreatmentConversion of FUraAddition of leucovorinSynergistic antitumor activityAbility of methotrexateTimes control valuesL1210 cellsEnhancement of intracellularSynergistic cell killingSoft agar cloningMethotrexate treatmentAntipurine effectMethotrexateConcentrations of methotrexateMaximal inhibitionControl valuesIntracellular methotrexateFUraInhibitory effectAntitumor activityExact mechanismIntracellular accumulationAgar cloningSimilar elevationsMicroM methotrexate
1979
Enhanced 5-Fluorouracil Nucleotide Formation After Methotrexate Administration: Explanation for Drug Synergism
Cadman E, Heimer R, Davis L. Enhanced 5-Fluorouracil Nucleotide Formation After Methotrexate Administration: Explanation for Drug Synergism. Science 1979, 205: 1135-1137. PMID: 472732, DOI: 10.1126/science.472732.Peer-Reviewed Original Research