1981
The influence of methotrexate pretreatment on 5-fluorouracil metabolism in L1210 cells.
Cadman E, Heimer R, Benz C. The influence of methotrexate pretreatment on 5-fluorouracil metabolism in L1210 cells. Journal Of Biological Chemistry 1981, 256: 1695-1704. PMID: 6161926, DOI: 10.1016/s0021-9258(19)69863-7.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiological TransportDeoxyuridineFluorouracilKineticsLeucovorinLeukemia L1210MethotrexateMicePhosphoribosyl PyrophosphatePurinesRNA, NeoplasmConceptsMethotrexate pretreatmentConversion of FUraAddition of leucovorinSynergistic antitumor activityAbility of methotrexateTimes control valuesL1210 cellsEnhancement of intracellularSynergistic cell killingSoft agar cloningMethotrexate treatmentAntipurine effectMethotrexateConcentrations of methotrexateMaximal inhibitionControl valuesIntracellular methotrexateFUraInhibitory effectAntitumor activityExact mechanismIntracellular accumulationAgar cloningSimilar elevationsMicroM methotrexate
1979
Enhanced 5-Fluorouracil Nucleotide Formation After Methotrexate Administration: Explanation for Drug Synergism
Cadman E, Heimer R, Davis L. Enhanced 5-Fluorouracil Nucleotide Formation After Methotrexate Administration: Explanation for Drug Synergism. Science 1979, 205: 1135-1137. PMID: 472732, DOI: 10.1126/science.472732.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedDrug Administration ScheduleDrug SynergismFluorouracilLeukemia L1210MethotrexateMicePhosphoribosyl PyrophosphateRibonucleotidesRNA, NeoplasmThymidylate Synthase