2022
Citrullination of glucokinase is linked to autoimmune diabetes
Yang ML, Horstman S, Gee R, Guyer P, Lam TT, Kanyo J, Perdigoto AL, Speake C, Greenbaum CJ, Callebaut A, Overbergh L, Kibbey RG, Herold KC, James EA, Mamula MJ. Citrullination of glucokinase is linked to autoimmune diabetes. Nature Communications 2022, 13: 1870. PMID: 35388005, PMCID: PMC8986778, DOI: 10.1038/s41467-022-29512-0.Peer-Reviewed Original ResearchConceptsGlucose-stimulated insulin secretionResult of inflammationType 1 diabetesBeta-cell metabolismPancreatic beta cellsAutoimmune diabetesNOD miceAutoreactive CD4Inflammatory cytokinesAutoimmune biomarkersInsulin secretionT cellsBeta cellsType 1InflammationBiologic activityReactive oxygen speciesDiabetesPost-translational modificationsDiabetes biomarkersGlycogen synthesisBiomarkersCitrullinationGlucokinaseOxygen species
2018
Epidermal growth factor receptor peptide vaccination induces cross-reactive immunity to human EGFR, HER2, and HER3
Doyle HA, Koski RA, Bonafé N, Bruck RA, Tagliatela SM, Gee RJ, Mamula MJ. Epidermal growth factor receptor peptide vaccination induces cross-reactive immunity to human EGFR, HER2, and HER3. Cancer Immunology, Immunotherapy 2018, 67: 1559-1569. PMID: 30056598, PMCID: PMC7268894, DOI: 10.1007/s00262-018-2218-9.Peer-Reviewed Original ResearchConceptsAntibody-dependent cell-mediated cytotoxicityEpidermal growth factor receptorAnti-tumor immunityMonoclonal antibody treatmentAntibody treatmentImmune serumElicit anti-tumor immunityAnti-EGFR monoclonal antibodiesHuman epidermal growth factor receptorPeptide-based vaccinationCross-reactive immunityT cell responsesCell-mediated cytotoxicityAnti-tumor antibodiesNatural anti-tumor antibodiesMDA-MB-453Tumor cell killingErbB family membersGrowth factor receptorPeptide vaccinationStandard chemotherapyImmune toleranceCurrent treatmentDrug infusionRadiation therapy
2013
Autoantigens: Novel forms and presentation to the immune system
Doyle HA, Yang ML, Raycroft MT, Gee RJ, Mamula MJ. Autoantigens: Novel forms and presentation to the immune system. Autoimmunity 2013, 47: 220-233. PMID: 24191689, DOI: 10.3109/08916934.2013.850495.Peer-Reviewed Original ResearchConceptsLupus autoimmunityPresence of autoantibodiesChronic autoimmune diseaseVariety of abnormalitiesAutoantigen presentationAutoimmune diseasesClinical expressionRelated syndromesImmune systemTissue pathologyAutoimmunityNon-genetic factorsAltered pathwaysMicroenvironmental influencesDiseasePresentationCell surfaceAutoantibodiesLupusSyndromeAbnormalities
2012
Lupus autoimmunity altered by cellular methylation metabolism
Yang ML, Gee AJ, Gee RJ, Zurita-Lopez CI, Khare S, Clarke SG, Mamula MJ. Lupus autoimmunity altered by cellular methylation metabolism. Autoimmunity 2012, 46: 21-31. PMID: 23039363, PMCID: PMC3543504, DOI: 10.3109/08916934.2012.732133.Peer-Reviewed Original ResearchConceptsS-adenosylmethionineTCR-mediated T cell proliferationImmune responseCell proliferationLupus-prone MRL/lpr miceT-cell activation markersMRL/lpr miceTh1/Th2 cytokinesB cell immune responsesMajor methyl donorDimethylarginine residuesT cell immunityCell activation markersT cell autoreactivityT cell responsesMethylated proteinsCell immune responsesTarget of autoimmunityT cell proliferationIncubation of cellsB cell proliferationDose-dependent mannerSAM metabolismLupus autoimmunityMethylation status