2012
Lupus autoimmunity altered by cellular methylation metabolism
Yang ML, Gee AJ, Gee RJ, Zurita-Lopez CI, Khare S, Clarke SG, Mamula MJ. Lupus autoimmunity altered by cellular methylation metabolism. Autoimmunity 2012, 46: 21-31. PMID: 23039363, PMCID: PMC3543504, DOI: 10.3109/08916934.2012.732133.Peer-Reviewed Original ResearchConceptsS-adenosylmethionineTCR-mediated T cell proliferationImmune responseCell proliferationLupus-prone MRL/lpr miceT-cell activation markersMRL/lpr miceTh1/Th2 cytokinesB cell immune responsesMajor methyl donorDimethylarginine residuesT cell immunityCell activation markersT cell autoreactivityT cell responsesMethylated proteinsCell immune responsesTarget of autoimmunityT cell proliferationIncubation of cellsB cell proliferationDose-dependent mannerSAM metabolismLupus autoimmunityMethylation status
2007
Altered immunogenicity of isoaspartate containing proteins
Doyle HA, Gee RJ, Mamula MJ. Altered immunogenicity of isoaspartate containing proteins. Autoimmunity 2007, 40: 131-137. PMID: 17453712, DOI: 10.1080/08916930601165180.Peer-Reviewed Original ResearchConceptsPost-translational modificationsIsoaspartyl residuesSuch post-translational modificationsContaining ProteinBiological processesLymphocyte developmentIsoaspartic acidCytochrome cProteinAspartic acidCathepsin DCathepsin digestionPigeon cytochrome cResiduesAntigen processingAltered immunogenicityCellsImmune systemNatural modificationBone marrowToleranceD. AdditionallyEnzymeSpontaneous conversionAcid
2006
Intracellular Protein Modification Associated with Altered T Cell Functions in Autoimmunity
Yang ML, Doyle HA, Gee RJ, Lowenson JD, Clarke S, Lawson BR, Aswad DW, Mamula MJ. Intracellular Protein Modification Associated with Altered T Cell Functions in Autoimmunity. The Journal Of Immunology 2006, 177: 4541-4549. PMID: 16982891, DOI: 10.4049/jimmunol.177.7.4541.Peer-Reviewed Original ResearchConceptsAutoimmune miceNZB/W miceAltered T cell functionT-cell proliferative defectsNZB/WMRL/lprT cell functionStrains of miceImmunologic responseW miceAntigenic stimulationT cellsT lymphocytesMRL miceMiceCell functionIntracellular levelsProliferative defectPhysiologic pHAgeNonenzymatic modificationAutoimmunityLymphocytesProtein processingKidneyB Cells Drive Early T Cell Autoimmunity In Vivo prior to Dendritic Cell-Mediated Autoantigen Presentation
Yan J, Harvey BP, Gee RJ, Shlomchik MJ, Mamula MJ. B Cells Drive Early T Cell Autoimmunity In Vivo prior to Dendritic Cell-Mediated Autoantigen Presentation. The Journal Of Immunology 2006, 177: 4481-4487. PMID: 16982884, DOI: 10.4049/jimmunol.177.7.4481.Peer-Reviewed Original ResearchConceptsAutoreactive T cellsDendritic cellsT cellsB cellsAutoantigen-specific B cellsAutoimmune T cell responsesSelf-reactive T cellsAutoantigen-presenting cellsExposure of autoantigensT cell autoimmunityT cell responsesTransgenic mouse modelAutoantigen presentationCell autoimmunityIg transgenic mouse modelProfessional APCsSelf-AgMouse modelEffective APCsCell responsesVivo studiesAutoimmunityLupusAPCCellsIsoaspartyl Post-translational Modification Triggers Anti-tumor T and B Lymphocyte Immunity*
Doyle HA, Zhou J, Wolff MJ, Harvey BP, Roman RM, Gee RJ, Koski RA, Mamula MJ. Isoaspartyl Post-translational Modification Triggers Anti-tumor T and B Lymphocyte Immunity*. Journal Of Biological Chemistry 2006, 281: 32676-32683. PMID: 16950786, DOI: 10.1074/jbc.m604847200.Peer-Reviewed Original ResearchConceptsTRP-2 peptideImmune toleranceT cellsNormal immune tolerancePeptide-pulsed targetsPeptide-immunized miceCytotoxic T lymphocytesB cell toleranceStrong immune responseTetramer analysisLymphocyte immunityMelanoma antigensT lymphocytesImmune responseCell toleranceImmune systemPost-translational protein modificationTyrosinase-related proteinCD8AntigenTumor proteinCellsImmunizationLymphocytesMice
2003
A Failure to Repair Self-Proteins Leads to T Cell Hyperproliferation and Autoantibody Production
Doyle HA, Gee RJ, Mamula MJ. A Failure to Repair Self-Proteins Leads to T Cell Hyperproliferation and Autoantibody Production. The Journal Of Immunology 2003, 171: 2840-2847. PMID: 12960305, DOI: 10.4049/jimmunol.171.6.2840.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoantibodiesAutoantigensBone Marrow TransplantationCD28 AntigensCell DivisionImmunophenotypingIsoaspartic AcidLupus Erythematosus, SystemicLymph NodesLymphocyte ActivationLymphoid TissueMiceMice, Inbred C57BLMice, KnockoutMitogensPhosphorylationProtein D-Aspartate-L-Isoaspartate MethyltransferaseReceptors, Antigen, T-CellSignal TransductionT-LymphocytesConceptsProtein carboxyl methyltransferasePhosphorylation of membersSpontaneous posttranslational modificationAg receptor stimulationCarboxyl methyltransferasePosttranslational modificationsBiological functionsT cell hyperproliferationCell homeostasisCell stressImmune toleranceT cellsT cell homeostasisSystemic lupus erythematosusPeripheral immune toleranceWild-type miceCell hyperproliferationAnti-DNA autoantibodiesHomeostasisLupus erythematosusAutoantibody productionAutoimmune pathologyKidney pathologyT lymphocytesEffector functions
1999
Isoaspartyl Post-translational Modification Triggers Autoimmune Responses to Self-proteins*
Mamula M, Gee R, Elliott J, Sette A, Southwood S, Jones P, Blier P. Isoaspartyl Post-translational Modification Triggers Autoimmune Responses to Self-proteins*. Journal Of Biological Chemistry 1999, 274: 22321-22327. PMID: 10428801, DOI: 10.1074/jbc.274.32.22321.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAspartic AcidAutoantibodiesAutoimmunityBinding, CompetitiveB-LymphocytesCytochrome c GroupHistocompatibility Antigens Class IIImmune ToleranceIsomerismLymphocyte ActivationMiceMice, Inbred MRL lprMolecular Sequence DataNuclear Magnetic Resonance, BiomolecularPeptide FragmentsProtein BindingProtein Processing, Post-TranslationalRibonucleoproteins, Small NuclearT-LymphocytesConceptsSystemic lupus erythematosusAutoimmune responseT cell autoimmune responsesHuman systemic lupus erythematosusInitiation of autoimmunityT cell compartmentT cell responsesImmunization of miceFunctioning immune systemLupus erythematosusSelf antigensAutoimmune diseasesImmunologic stimuliC-peptidePeptide autoantigensImmune systemCell responsesForeign pathogensImmunizationCytochrome c peptideMiceCell compartmentPresent studyPeptidesResponseT cell autoimmunity in Ig transgenic mice.
Shinde S, Gee R, Santulli-Marotto S, Bockenstedt L, Clarke S, Mamula M. T cell autoimmunity in Ig transgenic mice. The Journal Of Immunology 1999, 162: 7519-24. PMID: 10358207, DOI: 10.4049/jimmunol.162.12.7519.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationAutoantigensB-LymphocytesCD4-Positive T-LymphocytesFlow CytometryGenes, ImmunoglobulinHistocompatibility Antigens Class IILupus Erythematosus, SystemicMiceMice, Inbred C57BLMice, Inbred MRL lprMice, TransgenicPeptidesReceptors, Antigen, B-CellRibonucleoproteins, Small NuclearT-LymphocytesConceptsAutoreactive T cellsCD4 T cellsT cellsTransgenic miceB lymphocytesMRL-lpr/lpr miceLpr/lpr miceT cell autoimmunityAutoreactive B lymphocytesSystemic lupus erythematosusWild-type C57BL/6Wild-type miceC57BL/6 transgenic miceTransgenic B lymphocytesIg transgenic miceB cell APCCell autoimmunityLupus erythematosusLpr miceT lymphocytesMurine modelImmature phenotypeLymphocytesVivo activationMice
1995
Self-peptides in the initiation of lupus autoimmunity.
Bockenstedt LK, Gee RJ, Mamula MJ. Self-peptides in the initiation of lupus autoimmunity. The Journal Of Immunology 1995, 154: 3516-24. PMID: 7534800, DOI: 10.4049/jimmunol.154.7.3516.Peer-Reviewed Original ResearchConceptsSm small nuclear ribonucleoproteinsT cellsAutoreactive T cell proliferationDiverse autoimmune responseSystemic lupus erythematosusT cell responsesTypes of autoimmunityT cell proliferationD proteinsLupus autoimmunityLupus erythematosusLupus autoantigensAutoimmune responseAb responsesNormal miceForeign AgsSmall nuclear ribonucleoproteinImmune systemCell responsesHigh titersImmunofluorescence patternMolecular mimicsAmino acids 26Mouse lymphocytes