2003
A Failure to Repair Self-Proteins Leads to T Cell Hyperproliferation and Autoantibody Production
Doyle HA, Gee RJ, Mamula MJ. A Failure to Repair Self-Proteins Leads to T Cell Hyperproliferation and Autoantibody Production. The Journal Of Immunology 2003, 171: 2840-2847. PMID: 12960305, DOI: 10.4049/jimmunol.171.6.2840.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoantibodiesAutoantigensBone Marrow TransplantationCD28 AntigensCell DivisionImmunophenotypingIsoaspartic AcidLupus Erythematosus, SystemicLymph NodesLymphocyte ActivationLymphoid TissueMiceMice, Inbred C57BLMice, KnockoutMitogensPhosphorylationProtein D-Aspartate-L-Isoaspartate MethyltransferaseReceptors, Antigen, T-CellSignal TransductionT-LymphocytesConceptsProtein carboxyl methyltransferasePhosphorylation of membersSpontaneous posttranslational modificationAg receptor stimulationCarboxyl methyltransferasePosttranslational modificationsBiological functionsT cell hyperproliferationCell homeostasisCell stressImmune toleranceT cellsT cell homeostasisSystemic lupus erythematosusPeripheral immune toleranceWild-type miceCell hyperproliferationAnti-DNA autoantibodiesHomeostasisLupus erythematosusAutoantibody productionAutoimmune pathologyKidney pathologyT lymphocytesEffector functions
1999
B7 costimulation in the development of lupus: autoimmunity arises either in the absence of B7.1/B7.2 or in the presence of anti-b7.1/B7.2 blocking antibodies.
Liang B, Gee RJ, Kashgarian MJ, Sharpe AH, Mamula MJ. B7 costimulation in the development of lupus: autoimmunity arises either in the absence of B7.1/B7.2 or in the presence of anti-b7.1/B7.2 blocking antibodies. The Journal Of Immunology 1999, 163: 2322-9. PMID: 10438978, DOI: 10.4049/jimmunol.163.4.2322.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, AntinuclearAntibodies, BlockingAntibodies, MonoclonalAntigens, CDAutoantibodiesB7-1 AntigenB7-2 AntigenDNAGlomerulonephritisKidneyLupus Erythematosus, SystemicLymphocyte ActivationMembrane GlycoproteinsMiceMice, Inbred BALB CMice, Inbred C57BLMice, Inbred MRL lprMice, KnockoutRibonucleoproteins, Small NuclearConceptsMRL-lpr/lpr miceAnti-dsDNA autoantibodiesSystemic lupus erythematosusLpr miceAutoantibody expressionLupus erythematosusB7 costimulationAb treatmentMRL-lpr/lpr murine modelAnti-small nuclear ribonucleoproteinAge-matched wild-type miceHuman systemic lupus erythematosusMurine systemic lupus erythematosusDevelopment of lupusB7 costimulatory signalsWild-type miceB7.1/B7.2Autoantibody titersSevere glomerulonephritisSurface of APCsAutoantibody profileUntreated miceCostimulatory moleculesKidney pathologyT lymphocytes