2024
Estimating the direct effects of the genetic liabilities to bipolar disorder, schizophrenia, and behavioral traits on suicide attempt using a multivariable Mendelian randomization approach
Cabrera-Mendoza B, Aydin N, Fries G, Docherty A, Walss-Bass C, Polimanti R. Estimating the direct effects of the genetic liabilities to bipolar disorder, schizophrenia, and behavioral traits on suicide attempt using a multivariable Mendelian randomization approach. Neuropsychopharmacology 2024, 49: 1383-1391. PMID: 38396255, PMCID: PMC11250798, DOI: 10.1038/s41386-024-01833-2.Peer-Reviewed Original ResearchAssociated with higher oddsPsychiatric Genomics ConsortiumSubstance use disordersSocioeconomic factorsMendelian randomizationBipolar disorderGenetic liabilitySuicide attemptsHigher oddsTwo-sample Mendelian randomizationGenetic liability to bipolar disorderEffects of mental distressUK Biobank (UKBLiability to bipolar disorderMultivariable MR approachMendelian randomization approachComprehensive mental health assessmentGenome-wide association dataRisk of psychiatric disordersMental health assessmentBehavioral traitsAssociated with lonelinessHigh-risk individualsMental distressContext of SA
2023
Polysubstance addiction patterns among 7,989 individuals with cocaine use disorder
Stiltner B, Pietrzak R, Tylee D, Nunez Y, Adhikari K, Kranzler H, Gelernter J, Polimanti R. Polysubstance addiction patterns among 7,989 individuals with cocaine use disorder. IScience 2023, 26: 107336. PMID: 37554454, PMCID: PMC10405253, DOI: 10.1016/j.isci.2023.107336.Peer-Reviewed Original ResearchCocaine use disorderUse disordersAddiction patternsMixed bipolar episodesLatent class analysisDSM-5 diagnosisPosttraumatic stress disorderAntisocial personality disorderPsA severityMedication useHigher PSAPSA subgroupsHigher oddsBipolar episodesStress disorderPersonality disorderDisordersSubgroupsAgeSexClass analysisParticipantsComorbiditiesDiseaseDiagnosis
2022
APOL1 Risk Variants, Acute Kidney Injury, and Death in Participants With African Ancestry Hospitalized With COVID-19 From the Million Veteran Program
Hung AM, Shah SC, Bick AG, Yu Z, Chen HC, Hunt CM, Wendt F, Wilson O, Greevy RA, Chung CP, Suzuki A, Ho YL, Akwo E, Polimanti R, Zhou J, Reaven P, Tsao PS, Gaziano JM, Huffman JE, Joseph J, Luoh SW, Iyengar S, Chang KM, Casas JP, Matheny ME, O’Donnell C, Cho K, Tao R, Susztak K, Robinson-Cohen C, Tuteja S, Siew ED, Hung A, Wallbom A, Palacio A, Robey B, Jhala D, Fujii D, Cohen D, Boyko E, Jacono F, Villareal G, Garcon H, Gaziano J, Lichy J, Norton J, Beckham J, Whittle J, Huffman J, Moser J, Greco J, Walsh J, Harley J, Wells J, Klein J, Moorman J, Constans J, Fayad J, Casas J, Xu J, Liao K, Alexander K, Cho K, Hammer K, Oursler K, Mattocks K, Chang K, Dellitalia L, Hamner M, Whooley M, Murdoch M, Gaddy M, Godschalk M, Rauchman M, Huq M, Tandon N, Kosik N, Ratcliffe N, Okusaga O, Roussos P, Strollo P, Meyer P, Sriram P, Wilson P, Liang P, Tsao P, Balasubramanian P, Ramoni R, McArdle R, Hauger R, Servatius R, Smith R, Striker R, Mathew R, Gappy S, Pyarajan S, Gutierrez S, Gupta S, Aguayo S, Sharma S, Damrauer S, Kinlay S, Yeh S, Luoh S, Tuteja S, Mastorides S, Iyengar S, Bhushan S, Muralidhar S, Ahuja S, Liangpunsakul S, Assimes T, Morgan T, Stapley T, Sun Y, Ballas Z. APOL1 Risk Variants, Acute Kidney Injury, and Death in Participants With African Ancestry Hospitalized With COVID-19 From the Million Veteran Program. JAMA Internal Medicine 2022, 182: 386-395. PMID: 35089317, PMCID: PMC8980930, DOI: 10.1001/jamainternmed.2021.8538.Peer-Reviewed Original ResearchConceptsAcute kidney injuryNormal kidney functionHigh-risk groupAPOL1 risk variantsKidney functionAKI severityKidney injuryCohort studyMillion Veteran ProgramHigher oddsCOVID-19-associated acute kidney injuryRisk variantsMultivariable logistic regression analysisCOVID-19AKI risk factorsAKI severity stageRetrospective cohort studyAfrican ancestryApolipoprotein L1COVID-19 infectionCoronavirus disease 2019Logistic regression analysisHigh mortality rateVeteran ProgramAPOL1 kidney risk variants