2021
Posttraumatic Stress Disorder and Cardiovascular Disease
O’Donnell C, Longacre L, Cohen BE, Fayad ZA, Gillespie CF, Liberzon I, Pathak GA, Polimanti R, Risbrough V, Ursano RJ, Vander Heide R, Yancy CW, Vaccarino V, Sopko G, Stein MB. Posttraumatic Stress Disorder and Cardiovascular Disease. JAMA Cardiology 2021, 6: 1207-1216. PMID: 34259831, DOI: 10.1001/jamacardio.2021.2530.Peer-Reviewed Original ResearchConceptsPosttraumatic stress disorderAssociation of PTSDStress disorderTreatment of PTSDFunctional brain imaging studiesViolent personal assaultSevere psychological traumaBrain imaging studiesPotential causal connectionsMaladaptive reactionsPsychological traumaTraumatic eventsPTSD pathophysiologyHuman translational researchCardiovascular diseaseCVD outcomesAnatomical brain regionsPersonal assaultHuman-made disastersMilitary combatBrain regionsBrain changesHuman tissue biobanksBehavioral mechanismsRisk factors
2017
S100A10 identified in a genome-wide gene × cannabis dependence interaction analysis of risky sexual behaviours
Polimanti R, Meda SA, Pearlson GD, Zhao H, Sherva R, Farrer LA, Kranzler HR, Gelernter J. S100A10 identified in a genome-wide gene × cannabis dependence interaction analysis of risky sexual behaviours. Journal Of Psychiatry And Neuroscience 2017, 42: 252-261. PMID: 28418321, PMCID: PMC5487272, DOI: 10.1503/jpn.160189.Peer-Reviewed Original ResearchConceptsRisky sexual behaviorCAD diagnosisLow-frequency fluctuation (ALFF) analysisMultiple sexual partnersLeft paracentral lobuleSexual behaviorAfrican American cohortSemi-Structured AssessmentALFF analysisSexual functionAfrican American participantsCalcium-binding proteinsParacentral lobuleIndependent cohortRight pallidumCalcium homeostasisUnprotected sexCannabis dependenceDrug dependenceSignificant associationBrain regionsSexual partnersFrequency fluctuation analysisPrevious genome-wide association studyCohortPhenome-wide association study for CYP2A6 alleles: rs113288603 is associated with hearing loss symptoms in elderly smokers
Polimanti R, Jensen KP, Gelernter J. Phenome-wide association study for CYP2A6 alleles: rs113288603 is associated with hearing loss symptoms in elderly smokers. Scientific Reports 2017, 7: 1034. PMID: 28432340, PMCID: PMC5430682, DOI: 10.1038/s41598-017-01098-4.Peer-Reviewed Original ResearchConceptsLoss symptomsElderly subjectsAge-related hearing lossPhenome-wide association studyElderly smokersCigarette smokingNovel phenotypic associationsCerebellar hemisphereAuditory functionDiscovery cohortHearing lossReplication cohortBrain regionsSignificant associationNicotine metabolismCYP2A6 expressionCYP2A6 allelesMember 6Association studiesSmokingCohortSymptomsAssociationRegulatory roleInvolvement