2023
EARLY ADVERSITY CAUSES SEX-SPECIFIC DEFICITS IN ENTORHINAL-DORSAL HIPPOCAMPUS CONNECTIVITY AND CONTEXTUAL FEAR CONDITIONING IN ADOLESCENT MICE
Islam R, Arefin T, White J, Polis B, Ahmed S, Liu X, Zhang J, Kaffman A. EARLY ADVERSITY CAUSES SEX-SPECIFIC DEFICITS IN ENTORHINAL-DORSAL HIPPOCAMPUS CONNECTIVITY AND CONTEXTUAL FEAR CONDITIONING IN ADOLESCENT MICE. IBRO Neuroscience Reports 2023, 15: s103-s104. DOI: 10.1016/j.ibneur.2023.08.089.Peer-Reviewed Original Research
2022
Early life stress impairs synaptic pruning in the developing hippocampus
Dayananda KK, Ahmed S, Wang D, Polis B, Islam R, Kaffman A. Early life stress impairs synaptic pruning in the developing hippocampus. Brain Behavior And Immunity 2022, 107: 16-31. PMID: 36174883, PMCID: PMC10497209, DOI: 10.1016/j.bbi.2022.09.014.Peer-Reviewed Original ResearchConceptsSynaptic pruningMicroglial ramificationHippocampal functionAbnormal hippocampal functionCA1 pyramidal neuronsExpression of TREM2Increased spine densityRamification of microgliaEarly life adversityNormal hippocampal functionSynaptic engulfmentClinical outcomesPyramidal neuronsSpine densityFemale miceHippocampal stimulationSevere formHippocampal developmentPhagocytic activitySevere impairmentEx vivoLife adversityThird weekEarly adversityMice