Benzimidazolinone-Free Peptide o‑Aminoanilides for Chemical Protein Synthesis
Mannuthodikayil J, Singh S, Biswas A, Kar A, Tabassum W, Vydyam P, Bhattacharyya M, Mandal K. Benzimidazolinone-Free Peptide o‑Aminoanilides for Chemical Protein Synthesis. Organic Letters 2019, 21: 9040-9044. PMID: 31663760, DOI: 10.1021/acs.orglett.9b03440.Peer-Reviewed Original ResearchConceptsPeptide synthesisSolid-phase peptide synthesisChemical protein synthesisPhase peptide synthesisTotal chemical synthesisSerious side reactionsPeptide thioestersChemical synthesisEfficient synthesisSide reactionsDiaminobenzoic acidO-aminoanilidesSynthesisThioestersAminesBocFormationCarbamateHereinReactionOptional attachmentSolubility tagAcidPeptidesC-terminus